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Adhesion-GPCRs pp 179-188 | Cite as

Adhesion-GPCRs in the Male Reproductive Tract

  • Ben Davies
  • Christiane Kirchhoff
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 706)

Abstract

The male reproductive tract expresses a diverse array of adhesion-GPCRs, many in a highly specific and regulated manner. Despite this specificity of expression, little is known about the function of this receptor family in male reproductive physiology. Insights into function are beginning to emerge with the increasing availability of genetically modified mice harbouring mutations in these genes. Gpr64 is the best characterised of the adhesion-GPCRs in the male reproductive system and the phenotype of Gpr64 knock-out mice implicates this receptor in the regulation of fluid absorption in the efferent ducts and proximal epididymis. This chapter summarizes recent data concerning this receptor and other family members in the male reproductive system.

Keywords

Male Reproductive System Germ Cell Development Male Reproductive Tract Efferent Duct Taste Receptor Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Divina P, Vlcek C, Stmad P et al. Global transcriptome analysis of the C57BL/6J mouse testis by SAGE: evidence for nonrandom gene order. BMC Genomics 2005; 6(1):29.PubMedCrossRefGoogle Scholar
  2. 2.
    Johnston DS, Jelinsky SA, Bang HJ et al. The mouse epididymal transcriptome: transcriptional profiling of segmental gene expression in the epididymis. Biol Reprod 2005; 73(3):404–413.PubMedCrossRefGoogle Scholar
  3. 3.
    Bjarnadottir TK, Fredriksson R, Hoglund PJ et al. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics 2004; 84(1):23–33.PubMedCrossRefGoogle Scholar
  4. 4.
    Haitina T, Olsson F, Stephansson O et al. Expression profile of the entire family of Adhesion G protein-coupled receptors in mouse and rat. BMC Neurosci 2008; 9:43.PubMedCrossRefGoogle Scholar
  5. 5.
    Osterhoff C, Ivell R, Kirchhoff C. Cloning of a human epididymis-specific mRNA, HE6, encoding a novel member of the seven transmembrane-domain receptor superfamily. DNA Cell Biol 1997; 16(4):379–389.PubMedCrossRefGoogle Scholar
  6. 6.
    Obermann H, Samalecos A, Osterhoff C et al. HE6, atwo-subunit heptahelical receptor associated with apical membranes of efferent and epididymal duct epithelia. Mol Reprod Dev 2003; 64(1):13–26.PubMedCrossRefGoogle Scholar
  7. 7.
    Bjarnadottir TK, Fredriksson R, Schioth HB. The adhesion GPCRs: a unique family of G protein-coupled receptors with important roles in both central and peripheral tissues. Cell Mol Life Sci 2007; 64(16):2104–2119.PubMedCrossRefGoogle Scholar
  8. 8.
    Xu L, Begum S, Hearn JD et al. GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2 and inhibits melanoma tumor growth and metastasis. Proc Natl Acad Sci USA 2006; 103(24):9023–9028.PubMedCrossRefGoogle Scholar
  9. 9.
    Wang T, Ward Y, Tian L et al. CD97, an adhesion receptor on inflammatory cells, stimulates angiogenesis through binding integrin counterreceptors on endothelial cells. Blood 2005; 105(7):2836–2844.PubMedCrossRefGoogle Scholar
  10. 10.
    Kirchhoff C, Osterhoff C, Samalecos A. HE6/GPR64 adhesion receptor colocalizes with apical and subapical F-actin scaffold in male excurrent duct epithelia. Reproduction 2008; 136(2):235–245.PubMedCrossRefGoogle Scholar
  11. 11.
    Davies B, Baumann C, Kirchhoff C et al. Targeted deletion of the epididymal receptor HE6 results in fluid dysregulation and male infertility. Mol Cell Biol 2004; 24(19):8642–8648.PubMedCrossRefGoogle Scholar
  12. 12.
    Davies B, Behnen M, Cappallo-Obermann H et al. Novel epididymis-specific mRNAs downregulated by HE6/Gpr64 receptor gene disruption. Mol Reprod Dev 2007; 74(5):539–553.PubMedCrossRefGoogle Scholar
  13. 13.
    Van Itallie CM, Anderson JM. Claudins and epithelial paracellular transport. Annu Rev Physiol 2006; 68:403–429.PubMedCrossRefGoogle Scholar
  14. 14.
    Wagenfeld A, Yeung CH, Lehnert W et al. Lack of glutamate transporter EAAC1 in the epididymis of infertile c-ros receptor tyrosine-kinase deficient mice. J Androl 2002; 23(6):772–782.PubMedGoogle Scholar
  15. 15.
    Galligan CL, Baig E, Bykerk V et al. Distinctive gene expression signatures in rheumatoid arthritis synovial tissue fibroblast cells: correlates with disease activity. Genes Immun 2007; 8(6):480–491.PubMedCrossRefGoogle Scholar
  16. 16.
    Yamamoto Y, Irie K, Asada M et al. Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5) and a novel TEM5-like protein. Oncogene 2004; 23(22):3889–3897.PubMedCrossRefGoogle Scholar
  17. 17.
    Seandel M, James D, Shmelkov SV et al. Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature 2007; 449(7160):346–350.PubMedCrossRefGoogle Scholar
  18. 18.
    Dym M, He Z, Jiang J et al. Spermatogonial stem cells: unlimited potential. Reprod Fertil Dev 2009; 21(1):15–21.PubMedCrossRefGoogle Scholar
  19. 19.
    Formstone CJ, Little PF. The flamingo-related mouse Celsr family (Celsr1–3) genes exhibit distinct patterns of expression during embryonic development. Mech Dev 2001; 109(1):91–94.PubMedCrossRefGoogle Scholar
  20. 20.
    Curtin JA, Quint E, Tsipouri V et al. Mutation of Celsrl disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse. Curr Biol 2003; 13(13):1129–1133.PubMedCrossRefGoogle Scholar
  21. 21.
    Tissir F, Bar I, Jossin Y et al. Protocadherin Celsr3 is crucial in axonal tract development. Nat Neurosci 2005; 8(4):451–457.PubMedGoogle Scholar
  22. 22.
    Deltagen. MGI Direct Data Submission 2005; MGI:3604450.Google Scholar
  23. 23.
    Beall SA, Boekelheide K, Johnson KJ. Hybrid GPCR/cadherin (Celsr) proteins in rat testis are expressed with cell type specificity and exhibit differential Sertoli cell-germ cell adhesion activity. J Androl 2005; 26(4):529–538.PubMedCrossRefGoogle Scholar
  24. 24.
    Fritz IB. Somatic cell-germ cell relationships inmammalian testes during development and spermatogenesis. Ciba Found Symp 1994; 182:271–274; discussion 274–281.PubMedGoogle Scholar
  25. 25.
    McMillan DR, Kayes-Wandover KM, Richardson JA et al. Very large G protein-coupled receptor-1, the largest known cell surface protein, is highly expressed in the developing central nervous system. J Biol Chem 2002; 277(1):785–792.PubMedCrossRefGoogle Scholar
  26. 26.
    Skradski SL, Clark AM, Jiang H et al. A novel gene causing a mendelian audiogenic mouse epilepsy. Neuron 2001; 31(4):537–544.PubMedCrossRefGoogle Scholar
  27. 27.
    McGee J, Goodyear RJ, McMillan DR et al. The very large G-protein-coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles. J Neurosci 2006; 26(24):6543–6553.PubMedCrossRefGoogle Scholar
  28. 28.
    Yagi H, Tokano H, Maeda M et al. Vlgr1 is required for proper stereocilia maturation of cochlear hair cells. Genes Cells 2007; 12(2):235–250.PubMedCrossRefGoogle Scholar
  29. 29.
    Weston MD, Luijendijk MW, Humphrey KD et al. Mutations in the VLGR1 gene implicate G-protein signaling in the pathogenesis of Usher syndrome type II. Am J Hum Genet 2004; 74(2):357–366.PubMedCrossRefGoogle Scholar
  30. 30.
    Liu M, Parker RM, Darby K et al. GPR56, a novel secretin-like human G-protein-coupled receptor gene. Genomics 1999; 55(3):296–305.PubMedCrossRefGoogle Scholar
  31. 31.
    Piao X, Hill RS, Bodell A et al. G protein-coupled receptor-dependent development of human frontal cortex. Science 2004; 303(5666):2033–2036.PubMedCrossRefGoogle Scholar
  32. 32.
    Li S, Jin Z, Koirala S et al. GPR56 regulates pial basement membrane integrity and cortical lamination. J Neurosci 2008; 28(22):5817–5826.PubMedCrossRefGoogle Scholar
  33. 33.
    LopezJimenez ND, Sainz E, Cavenagh MM et al. Two novel genes, Gprl13, which encodes a family 2 G-protein-coupled receptor and Trcg1, are selectively expressed in taste receptor cells. Genomics 2005; 85(4):472–482.PubMedCrossRefGoogle Scholar
  34. 34.
    Zambrowicz BP, Abuin A, Ramirez-Solis R et al. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci USA 2003; 100(24):14109–14114.PubMedCrossRefGoogle Scholar
  35. 35.
    Kiessling AA, Mullen TE, Kiessling RL et al. Detection in Mice and Men of a Novel Class of Leukocyte/Macrophages Essential for Normal Development of Reproductive Tract Tissues. Fertility and sterility 2000; 74(3):S86.CrossRefGoogle Scholar
  36. 36.
    Cohen PE, Nishimura K, Zhu L et al. Macrophages: important accessory cells for reproductive function. J Leukoc Biol 1999; 66(5):765–772.PubMedGoogle Scholar

Copyright information

© Landes Bioscience and Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Ben Davies
    • 1
  • Christiane Kirchhoff
  1. 1.Wellcome Trust Centre for Human GeneticsUniversity of OxfordRoosevelt DriveUK

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