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Adhesion-GPCRs pp 149-156 | Cite as

F4/80: The Macrophage-Specific Adhesion-GPCR and its Role in Immunoregulation

  • Hsi-Hsien Lin
  • Martin Stacey
  • Joan Stein-Streilein
  • Siamon Gordon
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 706)

Abstract

Asamacrophage-restrictedreagent, the generation and application of the F4/80 mAb has greatly benefited the phenotypic characterization of mouse tissue macrophages for three decades. Following the molecular identification of the F4/80 antigen as an EGF-TM7 member of the adhesion-GPCR family, great interest was ignited to understand its cell type-specific expression pattern as well as its functional role in macrophage biology. Recent studies have shown that the F4/80 gene is regulated by a novel set of transcription factors that recognized a unique promoter sequence. Gene targeting experiments have produced two F4/80 knock out animal models and showed that F4/80 isnotrequired for normal macrophage development. Nevertheless, the F4/80 receptor was found to be necessary for the induction of efferent CD8+ regulatory T cells responsible for peripheral immune tolerance. The identification of cellular ligands for F4/80 and delineation of its signaling pathway remain elusive but are critical to understand the in vivo role of this macrophage-specific adhesion-GPCR.

Keywords

Treg Cell Cell Surface Glycoprotein Leukoc Biol Cellular Ligand Gene Target Experiment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Hsi-Hsien Lin
    • 1
  • Martin Stacey
  • Joan Stein-Streilein
  • Siamon Gordon
  1. 1.Department of Microbiology and Immunology, College of MedicineChang Gung UniversityKwei-SanTaiwan

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