Immunity and Adhesion-GPCRs
Adhesion-GPCRs are unusual, owing to their unique structure, comprising a large and complex extracellular domain composed of various common protein modules. Adhesion-GPCR family members are expressed ubiquitously; however the expression of each receptor is highly regulated and often restricted to specific cell types. The EGF-TM7 adhesion-GPCR subfamily members are predominantly expressed by leukocytes and involved in coordinating both the innate and acquired immune responses. Here we highlight some immunological insights in relation to EGF-TM7 proteins and other members of the adhesion-GPCR family.
KeywordsChondroitin Sulphate Acquire Immune Response Epidermal Growth Factor Domain Rheumatoid Synovial Tissue Human Neutrophil Function
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- 17.Hoek RM, de Launay D, Kop EN et al. Deletion of either CD55 or CD97 ameliorates arthritis in mouse models. Arthritis Rheum 62(4):1036–1042.Google Scholar
- 22.Yona S, Lin HH, Dri P et al. Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function. FASEB J 2007.Google Scholar