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Adhesion-GPCRs pp 121-127 | Cite as

Immunity and Adhesion-GPCRs

  • Simon Yona
  • Hsi-Hsien Lin
  • Martin Stacey
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 706)

Abstract

Adhesion-GPCRs are unusual, owing to their unique structure, comprising a large and complex extracellular domain composed of various common protein modules. Adhesion-GPCR family members are expressed ubiquitously; however the expression of each receptor is highly regulated and often restricted to specific cell types. The EGF-TM7 adhesion-GPCR subfamily members are predominantly expressed by leukocytes and involved in coordinating both the innate and acquired immune responses. Here we highlight some immunological insights in relation to EGF-TM7 proteins and other members of the adhesion-GPCR family.

Keywords

Chondroitin Sulphate Acquire Immune Response Epidermal Growth Factor Domain Rheumatoid Synovial Tissue Human Neutrophil Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Taylor PR, Martinez-Pomares L, Stacey M et al. Macrophage receptors and immune recognition. Annu Rev Immunol 2005; 23:901–944.PubMedCrossRefGoogle Scholar
  2. 2.
    Yona S, Lin HH, Siu WO et al. Adhesion-GPCRs: emerging roles for novel receptors. Trends Biochem Sci 2008;33(10):491–500.PubMedCrossRefGoogle Scholar
  3. 3.
    Chang GW, Davies JQ, Stacey M et al. CD312, the human adhesion-GPCR EMR2, is differentially expressed during differentiation, maturation and activation of myeloid cells. Biochem Biophys Res Commun 2007; 353(1):133–138.PubMedCrossRefGoogle Scholar
  4. 4.
    Hamann J WJ, van Lier RA, Smeets TJ et al. Expression of the activation antigen CD97 and its ligand CD55 in rheumatoid synovial tissue. Arthritis Rheum 1999; 42(4):650–658.PubMedCrossRefGoogle Scholar
  5. 5.
    Kwakkenbos MJ, Pouwels W, Matmati M et al. Expression of the largest CD97 and EMR2 isoforms on leukocytes facilitates a specific interaction with chondroitin sulfate on B-cells. J Leukoc Biol 2005; 77(1):112–119.PubMedGoogle Scholar
  6. 6.
    Leemans JC, te Velde AA, Florquin S et al. The Epidermal Growth Factor-Seven Transmembrane (EGF-TM7) Receptor CD97 Is Required for Neutrophil Migration and Host Defense. J Immunol 2004; 172(2):1125–1131.PubMedGoogle Scholar
  7. 7.
    Matmati M, Pouwels W, van Bruggen R et al. The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes. J Leukoc Biol 2007; 81(2):440–448.PubMedCrossRefGoogle Scholar
  8. 8.
    Stacey M, Chang GW, Davies JQ et al. The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachmentthrough chondroitin sulphate glycosaminoglycans. Blood 2003; 102(8):2916–2924.PubMedCrossRefGoogle Scholar
  9. 9.
    van Pel M, Hagoort H, Kwakkenbos MJ et al. Differential role of CD97 in interleukin-8-induced and granulocyte-colony stimulating factor-induced hematopoietic stem and progenitor cell mobilization. Haematologica 2008; 93(4):601–604.PubMedCrossRefGoogle Scholar
  10. 10.
    Yona S, Lin HH, Dri P et al. Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function. FASEB J 2008; 22(3):741–751.PubMedCrossRefGoogle Scholar
  11. 11.
    Austyn JM, Gordon S. F4/80, a monoclonal antibody directed specifically against the mouse macrophage. Eur J Immunol 1981; 11(10):805–815.PubMedCrossRefGoogle Scholar
  12. 12.
    Lin HH, Faunce D, Stacey M et al. The macrophage receptor F4/80 is involved in the induction of CD8+ regulatory T-cells in peripheral tolerance. J Exp Med 2005; 201(10): 1615–1625.PubMedCrossRefGoogle Scholar
  13. 13.
    Hamann J, Koning N, Pouwels W et al. EMR1, the human homolog of F4/80, is an eosinophil-specific receptor. Eur J Immunol 2007; 37(10):2797–2802.PubMedCrossRefGoogle Scholar
  14. 14.
    Stacey M, Chang GW, Sanos SL et al. EMR4, a novel epidermal growth factor (EGF)-TM7 molecule up-regulated in activated mouse macrophages, binds to a putative cellular ligand on B lymphoma cell line A20. J Biol Chem 2002; 277(32):29283–29293.PubMedCrossRefGoogle Scholar
  15. 15.
    Kwakkenbos MJ, Matmati M, Madsen O et al. An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2. FASEB J 2006; 20(14):2582–2584.PubMedCrossRefGoogle Scholar
  16. 16.
    Capasso M, Durrant LG, Stacey M et al. Costimulation via CD55 on human CD4+ T-cells mediated by CD97. J Immunol 2006; 177(2):1070–1077.PubMedGoogle Scholar
  17. 17.
    Hoek RM, de Launay D, Kop EN et al. Deletion of either CD55 or CD97 ameliorates arthritis in mouse models. Arthritis Rheum 62(4):1036–1042.Google Scholar
  18. 18.
    Lin HH, Chang GW, Huang YS et al. Multivalent protein probes for the identification and characterization of cognate cellular ligands for myeloid cell surface receptors. Methods Mol Biol 2009; 531:89–101.PubMedCrossRefGoogle Scholar
  19. 19.
    Prydz K, Dalen KT. Synthesis and sorting of proteoglycans. J Cell Sci 2000; 113 Pt 2:193–205.PubMedGoogle Scholar
  20. 20.
    Taylor KR, Gallo RL. Glycosaminoglycans and their proteoglycans: host-associated molecular patterns for initiation and modulation of inflammation. FASEB J 2006; 20(1):9–22.PubMedCrossRefGoogle Scholar
  21. 21.
    Kop EN, Kwakkenbos MJ, Teske GJ et al. Identification of the epidermal growth factor-TM7 receptor EMR2 and its ligand dermatan sulfate in rheumatoid synovial tissue. Arthritis Rheum 2005; 52(2):442–450.PubMedCrossRefGoogle Scholar
  22. 22.
    Yona S, Lin HH, Dri P et al. Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function. FASEB J 2007.Google Scholar
  23. 23.
    Visser L, de Vos AF, Hamann J et al. Expression of the EGF-TM7 receptor CD97 and its ligand CD55 (DAF) in multiple sclerosis. J Neuroimmunol 2002; 132(1-2):156–163.PubMedCrossRefGoogle Scholar
  24. 24.
    Kop EN, Adriaansen J, Smeets TJ et al. CD97 neutralisation increases resistance to collagen-induced arthritis in mice. Arthritis Res Ther 2006; 8(5):R155.PubMedCrossRefGoogle Scholar
  25. 25.
    Wang T, Tian L, Haino M et al. Improved antibacterial host defense and altered peripheral granulocyte homeostasis in mice lacking the adhesion class G protein receptor CD97. Infect Immun 2007; 75(3):1144–1153.PubMedCrossRefGoogle Scholar
  26. 26.
    Stacey M, Lin HH, Hilyard KL et al. Human Epidermal Growth Factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils. J Biol Chem 2001; 276(22): 18863–18870.PubMedCrossRefGoogle Scholar
  27. 27.
    Hamann J, Kwakkenbos MJ, de Jong EC et al. Inactivation of the EGF-TM7 receptor EMR4 after the Pan-Homo divergence. Eur J Immunol 2003; 33(5):1365–1371.PubMedCrossRefGoogle Scholar
  28. 28.
    Corbett AJ, Caminschi I, McKenzie BS et al. Antigen delivery via two molecules on the CD8 dendritic cell subset induces humoral immunity in the absence of conventional “danger”. Eur J Immunol 2005; 35(10):2815–2825.PubMedCrossRefGoogle Scholar
  29. 29.
    Park D, Tosello-Trampont AC, Elliott MR et al. BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature 2007; 450(7168):430–434.PubMedCrossRefGoogle Scholar
  30. 30.
    Della Chiesa M, Falco M et al. GPR56 as a novel marker identifying the CD56dull CD16+ NK cell subset both in blood stream and in inflamed peripheral tissues. Int Immunol 2010; 22(2):91–100.CrossRefGoogle Scholar

Copyright information

© Landes Bioscience and Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Simon Yona
  • Hsi-Hsien Lin
  • Martin Stacey
    • 1
  1. 1.Department of ImmunologyLeeds UniversityLeedsUK

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