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KSRP Promotes the Maturation of a Group of miRNA Precuresors

  • Michele Trabucchi
  • Paola Briata
  • Witold Filipowicz
  • Andres Ramos
  • Roberto Gherzi
  • Michael G. Rosenfeld
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 700)

Abstract

microrNNA (mirNAs) are small noncoding RNAs that down-regulate gene expression by reducing stability and/or translation of target mRNAs. In animals, miRNAs arise from sequential processing of hairpin primary transcripts by two rNase III domain-containing enzymes, namely Drosha and Dicer, to generate a mature form of about 22 nucleotides. In this chapter we discuss our latest fndings indicating that KSRP is an integral component of both Drosha and Dicer complexes. KSRP binds to the terminal loop sequence of a subset of miRNA precursors promoting their maturation. our data indicate that the terminal loop is a pivotal structure where activators of miRNA processing as well as repressors of miRNA processing act in a coordinated way to convert cellular signals into changes in miRNA expression processing. This uncovers a new level of complexity of miRNA mechanisms for gene expression regulation.

Keywords

miRNA Precursor miRNA Biogenesis miRNA Processing Terminal Loop microRNA Biogenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Michele Trabucchi
    • 1
  • Paola Briata
  • Witold Filipowicz
  • Andres Ramos
  • Roberto Gherzi
  • Michael G. Rosenfeld
  1. 1.Hughes Medical Institute, Department and School of MedicineUniversity of California, San DiegoLa JollaUSA

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