Pharmacological Treatment for Phobias and Anxiety Disorders
Anxiety disorders in childhood are quite common, affecting between 6 and 20% of all children (Costello, Mustillo, Erkanli, Keeler, & Angold, 2003). Anxiety disorders can adversely impact social and academic functioning as well as self-esteem (Mendlowicz & Stein, 2000). Children with anxiety disorders grow up to having greater rates of depression, new anxiety disorders, substance abuse, educational underachievement, and suicide attempts than the general population (Achenbach, Howell, McConaughy, & Stanger, 1995; Ferdinand, Verhulst, & Wiznitzer, 1995; Pine, Cohen, Gurley, Brook, & Ma, 1998; Woodward & Fergusson, 2001).
KeywordsAnxiety Disorder Cognitive Behavioral Therapy Selective Serotonin Reuptake Inhibitor Separation Anxiety Disorder Childhood Anxiety Disorder
The authors acknowledge the National Institute of Mental Health support of the Yale Child Study Center Research Training Program (MHB), NARSAD (MHB), Trichotillomania Learning Center (MHB), the National Institutes of Health Loan Repayment Program (MHB), and the APIRE/Eli Lilly Psychiatric Research Fellowship (MHB).
- American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders: DSM-IV-TR. Washington, DC: American Psychiatric Association.Google Scholar
- Barbanti, P., & Fabbrini, G. (2004). Migraine and Tourette syndrome. Archives of Neurology, 61(4), 606–607; author reply 607.Google Scholar
- Bridge, J. A., Iyengar, S., Salary, C. B., Barbe, R. P., Birmaher, B., Pincus, H. A., et al. (2007). Clinical response and risk for reported suicidal ideation and suicide attempts in pediatric antidepressant treatment: A meta-analysis of randomized controlled trials. JAMA, 297(15), 1683–1696.PubMedCrossRefGoogle Scholar
- Cohen, J. A., Mannarino, A. P., & Deblinger, E. (2006). Treating trauma and traumatic grief in children and adolescents. New York: Guilford.Google Scholar
- Geller, D. A., Biederman, J., Stewart, S. E., Mullin, B., Farrell, C., Wagner, K. D., et al. (2003). Impact of comorbidity on treatment response to paroxetine in pediatric obsessive-compulsive disorder: Is the use of exclusion criteria empirically supported in randomized clinical trials? Journal of Child and Adolescent Psychopharmacology, 13(Suppl 1), S19–S29.PubMedCrossRefGoogle Scholar
- Geller, D. A., Hoog, S. L., Heiligenstein, J. H., Ricardi, R. K., Tamura, R., Kluszynski, S., et al. (2001). Fluoxetine treatment for obsessive-compulsive disorder in children and adolescents: A placebo-controlled clinical trial. Journal of the American Academy of Child and Adolescent Psychiatry, 40(7), 773–779.PubMedCrossRefGoogle Scholar
- Gellar, D. A., Wagner, K. D., Emslie, G., Murphy, T., Carpenter, D. J., Wetherhold, E., Perera, P., Machin, A., Garnier, C. (2004). Paroxetine treatment in children and adolescents with obsessive-compulsive disorder: a randomized, multicenter, double-blind, placebo-controlled trial. J Am Acad Child Adolesc Psychiatry. 43(11), 1387–1396.Google Scholar
- Hammad, T. A. (2004). Review and evaluation of clinical data. Washington, DC, Food and Drug Administration, Aug 16,2004. Http://www.fda.gov/ohrms/dockets/ac/04/.
- Liebowitz, M. R., Stein, M. B., Tancer, M., Carpenter, D., Oakes, R., & Pitts, C. D. (2002). A randomized, double-blind, fixed-dose comparison of paroxetine and placebo in the treatment of generalized social anxiety disorder. The Journal of Clinical Psychiatry, 63(1), 66–74.PubMedCrossRefGoogle Scholar
- Nader, K. O., Kriegler, J. A., Blake, D. D., Pynoos, R. S., Newman, E., & Weathers, F. W. (1996). Clinician administered PTSD Scale for children and adolescents for DSM-IV. Los Angeles, CA: National Center for PTSD and UCLA Trauma Psychiatry Program, Department of Psychiatry, UCLA School of Medicine.Google Scholar
- Practice parameter for the assessment and treatment of children and adolescents with posttraumatic stress disorder. Retrieved February 28, 2010, from http://www.aacap.org/galleries/PracticeParameters/Final%20for%20Web%20December%202009%20PTSD.pdf
- Reinblatt, S. P., & Walkup, J. T. (2005). Psychopharmaco-logic treatment of pediatric anxiety disorders. Child and Adolescent Psychiatric Clinics of North America, 14(4), 877–908, x.Google Scholar
- Research Unit on Pediatric Psychopharmacology Anxiety Study Group, Fluvoxamine for the treatment of anxiety disorders in children and adolescents, N Engl J Med 344 (2001), pp. 1279–1285.Google Scholar
- Riddle, M. A., Reeve, E. A., Yaryura-Tobias, J. A., Yang, H. M., Claghorn, J. L., Gaffney, G., et al. (2001). Fluvoxamine for children and adolescents with obsessive-compulsive disorder: A randomized, controlled, multicenter trial. Journal of the American Academy of Child and Adolescent Psychiatry, 40(2), 222–229.PubMedCrossRefGoogle Scholar
- Robb, A., Cueva, J., Sporn, J., Yang, R., & Vanderburg, D. (2008). Efficacy of sertraline in childhood posttraumatic stress disorder. Paper presented at the American Academy of Child and Adolescent Psychiatry, Chicago, IL.Google Scholar
- Rupp (2001). Research Unit on Pediatric Psychopharmacology Anxiety Study Group, Fluvoxamine for the treatment of anxiety disorders in children and adolescents, N Engl J Med 344, pp.1279–1289Google Scholar
- Rynn, M. A., Riddle, M. A., Yeung, P. P., Kunz, N. R. (2007). Efficacy and safety of extended-release venlafaxine in the treatment of generalized anxiety disorder in children and adolescents: two placebo-controlled trials. Am J Psychiatry. 164(2), 290–300.Google Scholar
- Simeon, J. G., Ferguson, H. B., Knott, V., Roberts, N., Gauthier, B., Dubois, C., et al. (1992). Clinical, cognitive, and neurophysiological effects of alprazolam in children and adolescents with overanxious and avoidant disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 31(1), 29–33.PubMedCrossRefGoogle Scholar
- Simpson, H. B., Foa, E. B., Liebowitz, M. R., Ledley, D. R., Huppert, J. D., Chaill, S., et al. (2008). A randomized, controlled trail of cognitie-behavioral therapy for augmenting pharmacotherapy in obsessive-compulsive disorder. Am J Psychiatry. 165(5), 621–30.Google Scholar
- Wagner, K. D., Berard, R., Stein, M. B., Wetherhold, E., Carpenter, D. J., Perera, P., et al. (2004). A multicenter, randomized, double-blind, placebo-controlled trial of paroxetine in children and adolescents with social anxiety disorder. Archives of General Psychiatry, 61(11), 1153–1162.PubMedCrossRefGoogle Scholar