Gangliosides as Regulators of Cell Membrane Organization and Functions

Abstract

Gangliosides, characteristic complex lipids present in the external layer of plasma membranes, deeply influence the organization of the membrane as a whole and the function of specific membrane associated proteins due to lipid-lipid and lipid-protein lateral interaction. Here we discuss the basis for the membrane-organizing potential of gangliosides, examples of ganglioside-regulated membrane protein complexes and the mechanisms for the regulation of ganglioside membrane composition.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2010

Authors and Affiliations

  1. 1.Center of Excellence on Neurodegenerative Diseases Departments of Medical ChemistryBiochemistry and Biotechnology University of MilanSegrateItaly
  2. 2.Dipartimento di ChimicaBiochimica e Biotecnogie per la MedicinaSegrate (Mi)Italy

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