Structural Studies of NEMO and TRAF6: Implications in NF-κB Activation

Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 691)

Abstract

NF-κB proteins are evolutionarily conserved master regulators of immune and inflammatory responses [2]. They play critical roles in a wide array of biological processes including innate and adaptive immunity, oncogenesis, and development. They are activated in response to ligation of many receptors including T-cell receptors, B-cell receptors, members of the tumor necrosis factor (TNF) receptor superfamily, and the Toll-like receptor/interleukin-1 receptor (TLR/IL-1R) superfamily.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of BiochemistryWeill Cornell Medical CollegeNew YorkUSA

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