Workshop Summary: Roles of the TNF Family in Normal Development and Cancer

  • Nancy H. RuddleEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 691)


Lymphotoxin and TNF, the first TNF family members to be described, were originally assigned roles in inflammation or tumor rejection. The discovery that LT-deficient mice lacked lymph nodes and the discovery of multiple additional members of the family with distinctly non-inflammatory roles brought about the realization that many members of the family were crucial for normal development. Furthermore, TNF’s role in tumor defense has come under scrutiny in recent years with the realization that in some cases it can act as a tumor promoter.


Tumor Promoter Myeloid Derive Suppressor Cell Lymphatic Endothelial Cell Tumor Rejection Thymic Epithelial Cell 
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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Departments of Epidemiology and Public Health and ImmunobiologyYale University School of MedicineNew HavenUSA

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