Medication Adherence

  • Hayden B. BosworthEmail author


A key component in the management of health-care conditions is the use of prescribed medications. The effectiveness of medications and their long-term benefits depends on adherence to the prescriber’s instructions [1]. Adherence is defined as the extent to which people follow the instructions they are given for prescribed treatments [2]; it involves consumer choice and is intended to be non-judgmental, unlike compliance, which reinforces patient passivity and blame. On the other hand, concordance refers to an emerging consultative and consensual partnership between the consumer and their doctor [2]. Medication adherence behavior has been divided into two main concepts, namely adherence and persistence. Although conceptually similar, adherence refers to the intensity of drug use during the duration of therapy, whereas persistence refers to overall duration [3]. Medication non-adherence includes delaying prescription fills, failing to fill prescriptions, cutting dosages, and reducing the frequency of administration.


Medication Adherence Poor Adherence Fixed Dose Combination Pill Count Regimen Complexity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Sabate E. Adherence to long-term therapies: Evidence for action. Geneva, Switzerland: World Health Organization; 2003.Google Scholar
  2. 2.
    Haynes RB, Yao X, Degani A, Kripalani S, Garg A, McDonald HP. Interventions to enhance medication adherence. Cochrane Database Syst Rev. 2005;4:CD000011.PubMedGoogle Scholar
  3. 3.
    Cramer JA, Roy A, Burrell A, Fairchild CJ, Fuldeore MJ, Ollendorf DA, et al. Medication compliance and persistence: terminology and definitions. Value Health. 2008;11(1):44–47.PubMedCrossRefGoogle Scholar
  4. 4.
    World Health Organization. Adherence to long-term therapies: Evidence for action. Geneva: World Health Organization; 2003.Google Scholar
  5. 5.
    Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005;353(5):487–497.PubMedCrossRefGoogle Scholar
  6. 6.
    Benner JS, Glynn RJ, Mogun H, Neumann PJ, Weinstein MC, Avorn J. Long-term persistence in use of statin therapy in elderly patients. JAMA. 2002;288(4):455–461.PubMedCrossRefGoogle Scholar
  7. 7.
    Avorn J, Monette J, Lacour A, Bohn RL, Monane M, Mogun H, et al. Persistence of use of lipid-lowering medications: a cross-national study. JAMA. 1998;279(18):1458–1462.PubMedCrossRefGoogle Scholar
  8. 8.
    Balkrishnan R. The importance of medication adherence in improving chronic-disease related outcomes: what we know and what we need to further know. Med Care. 2005;43(6):517–520.PubMedCrossRefGoogle Scholar
  9. 9.
    Feldman R, Bacher M, Campbell N, Drover A, Chockalingam A. Adherence to pharmacologic management of hypertension. Can J Public Health. 1998;89(5):I16–I18.PubMedGoogle Scholar
  10. 10.
    Flack J, Novikov, SV, Ferrario CM. Benefits of adherence to antihypertensive drug therapy. Eur Soc Cardiol. 1996;17(Suppl A):16–20.Google Scholar
  11. 11.
    Mallion JM, Baguet JP, Siche JP, Tremel F, de Gaudemaris R. Compliance, electronic monitoring and antihypertensive drugs. J Hypertens Suppl. 1998;16(1):S75–S79.PubMedGoogle Scholar
  12. 12.
    Haynes RB, McKibbon KA, Kanani R. Systematic review of randomised trials of interventions to assist patients to follow prescriptions for medications. Lancet. 1996;348(9024):383–386.PubMedCrossRefGoogle Scholar
  13. 13.
    McDonnell PJ, Jacobs MR. Hospital admissions resulting from preventable adverse drug reactions. Ann Pharmacother. 2002;36(9):1331–1336.PubMedCrossRefGoogle Scholar
  14. 14.
    Rodgers PT, Ruffin DM. Medication nonadherence–Part I: the health and humanistic consequences. Manag Care Interface. 1998;11(8):58–60.PubMedGoogle Scholar
  15. 15.
    Schiff GD, Fung S, Speroff T, McNutt RA. Decompensated heart failure: symptoms, patterns of onset, and contributing factors. Am J Med. 2003;114(8):625–630.PubMedCrossRefGoogle Scholar
  16. 16.
    Senst BL, Achusim LE, Genest RP, Cosentino LA, Ford CC, Little JA, et al. Practical approach to determining costs and frequency of adverse drug events in a health care network. Am J Health Syst Pharm. 2001;58(12):1126–1132.PubMedGoogle Scholar
  17. 17.
    Ho PM, Rumsfeld JS, Masoudi FA, McClure DL, Plomondon ME, Steiner JF, et al. Effect of medication nonadherence on hospitalization and mortality among patients with diabetes mellitus. Arch Intern Med. 2006;166(17):1836–1841.PubMedCrossRefGoogle Scholar
  18. 18.
    McCarthy R. The price you pay for the drug not taken. Bus Health 1998;16:27–33.PubMedGoogle Scholar
  19. 19.
    National Council on Patient Information and Education. Enhancing prescription medication adherence: a national action plan Accessed 6/2/2008.
  20. 20.
    Berg JS, Dischler J, Wagner DJ, Raia JJ, Palmer-Shevlin N. Medication compliance: a healthcare problem. Ann Pharmacother. 1993;27(9 Suppl):S1–S24.PubMedGoogle Scholar
  21. 21.
    Levy G, Zamacona MK, Jusko WJ. Developing compliance instructions for drug labeling. Clin Pharmacol Ther. 2000;68(6):586–591.PubMedCrossRefGoogle Scholar
  22. 22.
    DiMatteo MR, Giordani PJ, Lepper HS, Croghan TW. Patient adherence and medical treatment outcomes: a meta-analysis. Med Care. 2002;40(9):794–811.PubMedCrossRefGoogle Scholar
  23. 23.
    Stephenson BJ, Rowe BH, Haynes RB, Macharia WM, Leon G. Is this patient taking the treatment as prescribed? JAMA. 1993;269(21):2779–2781.PubMedCrossRefGoogle Scholar
  24. 24.
    Choo PW, Rand CS, Inui TS, Lee ML, Cain E, Cordeiro-Breault M, et al. Validation of patient reports, automated pharmacy records, and pill counts with electronic monitoring of adherence to antihypertensive therapy. Med Care. 1999;37(9):846–857.PubMedCrossRefGoogle Scholar
  25. 25.
    Steiner JF, Prochazka AV. The assessment of refill compliance using pharmacy records: methods, validity, and applications. J Clin Epidemiol. 1997;50(1):105–116.PubMedCrossRefGoogle Scholar
  26. 26.
    Rosen MI, Rigsby MO, Salahi JT, Ryan CE, Cramer JA. Electronic monitoring and counseling to improve medication adherence. Behav Res Ther. 2004;42(4):409–422.PubMedCrossRefGoogle Scholar
  27. 27.
    Morisky E, Green, LW, Levine, DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care. 1986;24:67–74.PubMedCrossRefGoogle Scholar
  28. 28.
    Thorpe C, Bryson CL, Maciejewski, ML, Bosworth, HB. Medication acquisition and self-reported adherence in veterans with hypertension. Med Care. 2009;47(4): 474–481.PubMedCrossRefGoogle Scholar
  29. 29.
    Morgan AL, Masoudi FA, Havranek EP, Jones PG, Peterson PN, Krumholz HM, et al. Difficulty taking medications, depression, and health status in heart failure patients. J Card Fail. 2006;12(1):54–60.PubMedCrossRefGoogle Scholar
  30. 30.
    Hansen RA, Kim MM, Song L, Tu W, Wu J, Murray MD. Comparison of methods to assess medication adherence and classify nonadherence. Ann Pharmacother. 2009;43(3):413–422.PubMedCrossRefGoogle Scholar
  31. 31.
    Dunbar-Jacob J, Dwyer K, Dunning EJ. Compliance with antihypertensive regimen: a review of the research in the 1980s. Ann Behav Med. 1991;13(1):31–39.Google Scholar
  32. 32.
    Haynes RB, McDonald HP, Garg AX. Helping patients follow prescribed treatment: clinical applications. JAMA. 2002;288(22):2880–2883.PubMedCrossRefGoogle Scholar
  33. 33.
    Shalansky SJ, Levy AR, Ignaszewski AP. Self-reported Morisky score for identifying nonadherence with cardiovascular medications (September). Ann Pharmacother. 2004;38(9):1363–1368.Google Scholar
  34. 34.
    Stephenson BJ, Rowe BH, Haynes RB, Macharia WM, Leon G. The rational clinical examination. Is this patient taking the treatment as prescribed? JAMA. 1993;269(21):2779–2781.PubMedCrossRefGoogle Scholar
  35. 35.
    Lowry KP, Dudley TK, Oddone EZ, Bosworth HB. Intentional and unintentional nonadherence to antihypertensive medication. Ann Pharmacother. 2005;39(7–8):1198–1203.PubMedCrossRefGoogle Scholar
  36. 36.
    Bosworth HB, George LK, Hays JC, Steffens DC. Psychosocial and clinical factors as predictors of the outcome of unipolar depression. Int J Geriatr Psychiatry. 2002;17(3):238–246.PubMedCrossRefGoogle Scholar
  37. 37.
    Bosworth HB, Olsen MK, Oddone EZ. Improving blood pressure control by tailored feedback to patients and clinicians. Am Heart J. 2005;149(5):795–803.PubMedCrossRefGoogle Scholar
  38. 38.
    Bosworth HB. Medication adherence. In: Bosworth HB. OE, Weinberger M, eds. Patient treatment adherence: Concepts, interventions, and measurement. Mahwah, NJ: Lawrence Erlbaum Associates; 2006.Google Scholar
  39. 39.
    Ickovics JR, Meisler AW. Adherence in AIDS clinical trials: a framework for clinical research and clinical care. J Clin Epidemiol. 1997;50(4):385–391.PubMedCrossRefGoogle Scholar
  40. 40.
    Haynes RB, McDonald H, Garg AX, Montague P. Interventions for helping patients to follow prescriptions for medications. Cochrane Database Syst Rev. 2002;2:CD000011.PubMedGoogle Scholar
  41. 41.
    McDonald HP, Garg AX, Haynes RB. Interventions to enhance patient adherence to medication prescriptions: scientific review. JAMA. 2002;288(22):2868–2879.PubMedCrossRefGoogle Scholar
  42. 42.
    Ingersoll KS, Cohen J. The impact of medication regimen factors on adherence to chronic treatment: a review of literature. J Behav Med. 2008;31(3):213–224.PubMedCrossRefGoogle Scholar
  43. 43.
    Richter A, Anton SE, Koch P, Dennett SL. The impact of reducing dose frequency on health outcomes. Clin Ther. 2003;25(8):2307–2335; discussion 6.PubMedCrossRefGoogle Scholar
  44. 44.
    Seedat YK. Fixed drug combination in hypertension and hyperlipidaemia in the developing world. Cardiovasc J Afr. 2008;19(3):124–126.PubMedGoogle Scholar
  45. 45.
    Makaryus AN, Friedman EA. Patients’ understanding of their treatment plans and diagnosis at discharge. Mayo Clin Proc. 2005;80(8):991–994.PubMedCrossRefGoogle Scholar
  46. 46.
    Coleman EA, Mahoney E, Parry C. Assessing the quality of preparation for posthospital care from the patient’s perspective: the care transitions measure. Med Care. 2005;43(3):246–255.PubMedCrossRefGoogle Scholar
  47. 47.
    Wamala S, Merlo J, Bostrom G, Hogstedt C, Agren G. Socioeconomic disadvantage and primary non-adherence with medication in Sweden. Int J Qual Health Care. 2007;19(3):134–140.PubMedCrossRefGoogle Scholar
  48. 48.
    McCray AT. Promoting health literacy. J Am Med Inform Assoc. 2005;12:152–163.PubMedCrossRefGoogle Scholar
  49. 49.
    Institute of Medicine. Health literacy. A prescription to end confusion. Washington, DC: National Academies Press; 2004.Google Scholar
  50. 50.
    United States Department of Education. National assessment of adult literacy: A first look at the literacy of America’s adults in the 21st century. Washington, DC: National Center for Education Statistics; 2005.Google Scholar
  51. 51.
    Gazmararian JA, Baker DW, Williams MV, Parker RM, Scott TL, Green DC, et al. Health literacy among Medicare enrollees in a managed care organization. JAMA. 1999;281(6):545–551.PubMedCrossRefGoogle Scholar
  52. 52.
    Williams M, Parker, RM., Baker, DW, et al. Inadequate functional health literacy among patients at two public hospitals. J Am Med Assoc. 1995;274(21):1677–1682.CrossRefGoogle Scholar
  53. 53.
    Wilson FL, Racine E, Tekieli V, Williams B. Literacy, readability and cultural barriers: critical factors to consider when educating older African Americans about anticoagulation therapy. J Clin Nurs. 2003;12(2):275–282.PubMedCrossRefGoogle Scholar
  54. 54.
    Nelson W, Reyna VF, Fagerlin A, Lipkus I, Peters E. Clinical implications of numeracy: theory and practice. Ann Behav Med. 2008;35(3):261–274.PubMedCrossRefGoogle Scholar
  55. 55.
    Gazmararian JA, Williams MV, Peel J, Baker DW. Health literacy and knowledge of chronic disease. Patient Educ Couns. 2003;51(3):267–275.PubMedCrossRefGoogle Scholar
  56. 56.
    Parker RM, Gazmararian JA. Health literacy: essential for health communication. J Health Commun. 2003;8(Suppl 1):116–118.PubMedCrossRefGoogle Scholar
  57. 57.
    Mehta S, Moore RD, Graham NM. Potential factors affecting adherence with HIV therapy. AIDS. 1997;11(14):1665–1670.PubMedCrossRefGoogle Scholar
  58. 58.
    Isaac IM, Tamblyn RM. Compliance and cognitive function: a methodological approach to measuring unintentional errors in medication compliance in the elderly. Gerontologist. 1993;33:772–781.PubMedCrossRefGoogle Scholar
  59. 59.
    Tarn DM, Heritage J, Paterniti DA, Hays RD, Kravitz RL, Wenger NS. Physician communication when prescribing new medications. Arch Intern Med. 2006;166(17):1855–1862.PubMedCrossRefGoogle Scholar
  60. 60.
    Svarstad BL, Bultman DC, Mount JK. Patient counseling provided in community pharmacies: effects of state regulation, pharmacist age, and busyness. J Am Pharm Assoc 2004;44(1):22–29.CrossRefGoogle Scholar
  61. 61.
    Shrank WH, Avorn J. Educating patients about their medications: the potential and limitations of written drug information. Health Aff (Millwood). 2007;26(3):731–740.CrossRefGoogle Scholar
  62. 62.
    Lee PP, Hoskins HD, Jr., Parke DW, 3rd. Access to care: eye care provider workforce considerations in 2020. Arch Ophthalmol. 2007;125(3):406–410.PubMedCrossRefGoogle Scholar
  63. 63.
    Simmons D, Rush E, Crook N. Development and piloting of a community health worker-based intervention for the prevention of diabetes among New Zealand Maori in Te Wai o Rona: Diabetes Prevention Strategy. Public Health Nutr. 2008;11(12):1318–1325.PubMedCrossRefGoogle Scholar
  64. 64.
    Simmons D, Voyle J, Rush E, Dear M. The New Zealand experience in peer support interventions among people with diabetes. Fam Pract. 2009:1–9.Google Scholar
  65. 65.
    Organization WH. Adherence to long-term therapies: Evidence for action. Geneva: World Health Organization; 2003.Google Scholar
  66. 66.
    Paez KA, Zhao L, Hwang W. Rising out-of-pocket spending for chronic conditions: a ten-year trend. Health Aff (Millwood). 2009;28(1):15–25.CrossRefGoogle Scholar
  67. 67.
    Solomon MD, Goldman DP, Joyce GF, Escarce JJ. Cost sharing and the initiation of drug therapy for the chronically ill. Arch Intern Med. 2009;169(8):740–748; discussion 8–9.PubMedCrossRefGoogle Scholar
  68. 68.
    Safran DG, Neuman P, Schoen C, Kitchman MS, Wilson IB, Cooper B, et al. Prescription drug coverage and seniors: findings from a 2003 national survey. Health Aff (Millwood). 2005; Suppl Web Exclusives:W5-152-W5-66.Google Scholar
  69. 69.
    Balint S, O’Donnell R. Beyond compliance. Occup Health Saf (Waco, Tex.) 2007;76(6):104, 6–7.PubMedGoogle Scholar
  70. 70.
    Misra A, Ganda OP. Migration and its impact on adiposity and type 2 diabetes. Nutrition (Burbank, Los Angeles County, California). 2007;23(9):696–708.PubMedCrossRefGoogle Scholar
  71. 71.
    Haynes RB, Ackloo E, Sahota N, McDonald HP, Yao X. Interventions for enhancing medication adherence. Cochrane Database Syst Rev. 2008(2):CD000011.Google Scholar
  72. 72.
    Kripalani S, Yao X, Haynes RB. Interventions to enhance medication adherence in chronic medical conditions: a systematic review. Arch Intern Med. 2007;167(6):540–550.PubMedCrossRefGoogle Scholar
  73. 73.
    Conn VS, Hafdahl AR, Cooper PS, Ruppar TM, Mehr DR, Russell CL. Interventions to improve medication adherence among older adults: meta-analysis of adherence outcomes among randomized controlled trials. Gerontologist. 2009;49(4):447–462.PubMedCrossRefGoogle Scholar
  74. 74.
    Miller N, Hill, MN, Kottke T, Ockene IS. The multilevel compliance challenge: recommendations for a call to action. A statement for healthcare professionals. Circulation. 1997;95:1085–1090.PubMedCrossRefGoogle Scholar
  75. 75.
    Hill MN, Miller NH. Compliance enhancement. A call for multidisciplinary team approaches. Circulation. 1996;93(1):4–6.PubMedCrossRefGoogle Scholar
  76. 76.
    Schlenk EA, Bernardo LM, Organist LA, Klem ML, Engberg S. Optimizing medication adherence in older patients: a systematic review. J Clin Outcomes Manag. 2008;15(12):595–606.PubMedGoogle Scholar
  77. 77.
    Russell CL, Conn VS, Jantarakupt P. Older adult medication compliance: integrated review of randomized controlled trials. Am J Health Behav. 2006;30(6):636–650.PubMedCrossRefGoogle Scholar
  78. 78.
    van Eijken M, Tsang S, Wensing M, de Smet PA, Grol RP. Interventions to improve medication compliance in older patients living in the community: a systematic review of the literature. Drugs Aging. 2003;20(3):229–240.PubMedCrossRefGoogle Scholar
  79. 79.
    Russel M. Behavioral counseling in medicine: Strategies for modifying at-risk behavior. New York, NY: Oxford; 1986.Google Scholar
  80. 80.
    Taylor CB, Miller, NH. The behavioral approach. In: Wenger NK, Weinstein HK, eds. Rehabilitation of the coronary patient. New York, NY: Churchill Livingstone; 1992:461–471.Google Scholar
  81. 81.
    Heyscue BE, Levin GM, Merrick JP. Compliance with depot antipsychotic medication by patients attending outpatient clinics. Psychiatr Serv. 1998;49(9):1232–1234.PubMedGoogle Scholar
  82. 82.
    Patton K, Meyers J, Lewis BE. Enhancement of compliance among patients with hypertension. Am J Manag Care. 1997;3(11):1693–1698.PubMedGoogle Scholar
  83. 83.
    Berkman LF. Assessing the physical health effects of social networks and social support. Ann Rev Public Health. 1984;5:413–432.CrossRefGoogle Scholar
  84. 84.
    Cohen S. Social relationships and health. Am Psychol. 2004;59(8):676–684.PubMedCrossRefGoogle Scholar
  85. 85.
    DiMatteo MR. Social support and patient adherence to medical treatment: a meta-analysis. Health Psychol. 2004;23(2):207–218.PubMedCrossRefGoogle Scholar
  86. 86.
    McCann BS, Retzlaff BM, Dowdy AA, Walden CE, Knopp RH. Promoting adherence to low-fat, low-cholesterol diets: review and recommendations. J Am Diet Assoc. 1990;90(10):1408–1414.PubMedGoogle Scholar
  87. 87.
    Bovbjerg VE, McCann BS, Brief DJ, Follette WC, Retzlaff BM, Dowdy AA, et al. Spouse support and long-term adherence to lipid-lowering diets. Am J Epidemiol. 1995;141(5):451–460.PubMedGoogle Scholar
  88. 88.
    Catz SL, Kelly JA, Bogart LM, Benotsch EG, McAuliffe TL. Patterns, correlates, and barriers to medication adherence among persons prescribed new treatments for HIV disease. Health Psychol. 2000;19(2):124–133.PubMedCrossRefGoogle Scholar
  89. 89.
    Sherbourne CD, Hays RD, Ordway L, DiMatteo MR, Kravitz RL. Antecedents of adherence to medical recommendations: results from the medical outcomes study. J Behav Med. 1992;15(5):447–468.PubMedCrossRefGoogle Scholar
  90. 90.
    Ogedegbe G, Harrison M, Robbins L, Mancuso CA, Allegrante JP. Barriers and facilitators of medication adherence in hypertensive African Americans: a qualitative study. Ethn Dis. 2004;14(1):3–12.PubMedGoogle Scholar
  91. 91.
    Molassiotis A, Nahas-Lopez V, Chung WY, Lam SW, Li CK, Lau TF. Factors associated with adherence to antiretroviral medication in HIV-infected patients. Intern J STD AIDS. 2002;13(5):301–310.CrossRefGoogle Scholar
  92. 92.
    Voils C, Steinhauser K, McCant F, Oddone E, Bosworth HB. Understanding adherence to blood pressure-lowering regimens: A qualitative study of facilitators and barriers. Baltimore, MD: Health Services Research and Development National Meeting; 2005.Google Scholar
  93. 93.
    Kopjar B, Sales AE, Pineros SL, Sun H, Li YF, Hedeen AN. Adherence with statin therapy in secondary prevention of coronary heart disease in veterans administration male population. Am J Cardiol. 2003;92(9):1106–1108.PubMedCrossRefGoogle Scholar
  94. 94.
    Pratt J, Jones, JJ. Noncompliance with therapy: an ongoing problem in treating hypertension. Prim Cardiol. 1995;21:34–38.Google Scholar
  95. 95.
    Urquhart J. Correlates of variable patient compliance in drug trials: relevance in the new health care environment. Adv Drug Res. 1995;26:237–257.CrossRefGoogle Scholar
  96. 96.
    Sivarajan ES, Newton KM, Almes MJ, Kempf TM, Mansfield LW, Bruce RA. Limited effects of outpatient teaching and counseling after myocardial infarction: a controlled study. Heart Lung. 1983;12(1):65–73.PubMedGoogle Scholar
  97. 97.
    Haynes R, Sackett DL, Gibson ES, Taylor DW, Hackett BC, Roberts RS, Johnson AL. Improvement of medication compliance in uncontrolled hypertension. Lancet. 1976;1:1265–1268.PubMedCrossRefGoogle Scholar
  98. 98.
    Bailey WC, Richards JM, Jr., Brooks CM, Soong SJ, Windsor RA, Manzella BA. A randomized trial to improve self-management practices of adults with asthma. Arch Intern Med. 1990;150(8):1664–1668.PubMedCrossRefGoogle Scholar
  99. 99.
    Levine RJ. Monitoring for adherence: ethical considerations. Am J Respir Crit Care Med. 1994;149(2 Pt 1):287–288.PubMedGoogle Scholar
  100. 100.
    Ciechanowski PS, Katon WJ, Russo JE, Walker EA. The patient-provider relationship: attachment theory and adherence to treatment in diabetes. Am J Psychiatry. 2001;158(1):29–35.PubMedCrossRefGoogle Scholar
  101. 101.
    Alexander SC, Sleath B, Golin CE, Kalinowski CT. Patient-provider communication. In: Bosworth HB, Oddone EZ, Weinberger M, eds. Patient treatment adherence: Concepts, interventions, and measurement. Mahwah, NJ: Lawrence Erlbaum Associates; 2006:329–372.Google Scholar
  102. 102.
    Bender BG. Overcoming barriers to nonadherence in asthma treatment. J Allergy Clin Immunol. 2002;109(6 Suppl):S554–S559.PubMedCrossRefGoogle Scholar
  103. 103.
    Horne R. Patients’ beliefs about treatment: the hidden determinant of treatment outcome? J Psychosom Res. 1999;47(6):491–495.PubMedCrossRefGoogle Scholar
  104. 104.
    Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The heart outcomes prevention evaluation study investigators. N Engl J Med. 2000;342(3):145–153.PubMedCrossRefGoogle Scholar
  105. 105.
    Haynes RB, Montague P, Oliver T, McKibbon KA, Brouwers MC, Kanani R. Interventions for helping patients to follow prescriptions for medications. Cochrane Database Syst Rev. 2000;2:CD000011.PubMedGoogle Scholar

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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Center for Health Services Research in Primary CareDurham Veterans Affairs Medical CenterDurhamUSA
  2. 2.Departments of Medicine and Psychiatry and Behavioral Sciences, School of NursingDuke University Medical CenterDurhamUSA

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