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Scleroderma pp 591-602 | Cite as

Cell-Based Therapies

  • Alan G. TyndallEmail author
  • Keith M. Sullivan
Chapter

Abstract

Cell therapy describes the process of introducing new cells into a tissue in order to treat a disease. Cell therapies often focus on the treatment of hereditary diseases, with or without the addition of gene therapy. There are many potential forms of cell therapy: the transplantation of stem cells that are autologous (from the patient) or allogeneic (from another donor), the transplantation of mature, functional cells, the application of modified human cells that are used to produce a needed substance, the xenotransplantation of non-human cells that are used to produce a needed substance (e.g., treating diabetic patients by introducing insulin-producing pig cells directly into their muscle) and the transplantation of trans-differentiated cells derived from the patient’s own differentiated cells (e.g., the use of insulin producing beta cells trans-differentiated from isolated hepatocytes as a treatment for diabetes).

Keywords

Allogeneic HSCT autologous hematopoietic stem cell transplantation (HSCT) autoreactive graft-versus-host disease immunoablation multipotent mesenchymal stromal cells stem cells 

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of RheumatologyFelix Plater Spital BaselBaselSwitzerland
  2. 2.Department of Medicine, Division of Cellular TherapyDuke University Medical CenterDurhamUSA

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