Controlling Hospital-Acquired Infection due to Carbapenem-Resistant Enterobacteriaceae (CRE)

  • Mitchell J. SchwaberEmail author
  • Yehuda Carmeli
  • Stephan Harbarth


CRE impede effective therapy of patients with Gram-negative infections. They affect patients with poor functional status, prolonged hospital stay and multiple exposures to different antibiotic agents. Detecting carbapenemase-mediated carbapenem resistance is a challenge for many microbiology laboratories using automated susceptibility testing systems. To prevent nosocomial and community transmission of CRE, we recommend strict infection control measures—including contact isolation, cohorting of carriers, and dedicated staffing—alongside active surveillance of patients at risk for carriage. Little is known regarding the added value of antibiotic stewardship interventions to control epidemic or endemic transmission of CRE.


Antibiotic resistance Acinetobacter Pseudomonas KPC Metallo beta-lactamase OXA 


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Mitchell J. Schwaber
    • 1
    Email author
  • Yehuda Carmeli
    • 1
    • 2
  • Stephan Harbarth
    • 3
  1. 1.National Center for Infection ControlIsrael Ministry of HealthTel AvivIsrael
  2. 2.Division of Epidemiology and Preventive MedicineTel Aviv Sourasky Medical CenterTel AvivIsrael
  3. 3.Infection Control ProgramGeneva University Hospitals & Medical SchoolGeneva 14Switzerland

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