Molecular Pathology of Endocrine Diseases

Volume 3 of the series Molecular Pathology Library pp 95-101


Poorly Differentiated and Undifferentiated Thyroid Carcinomas

  • Jennifer L. HuntAffiliated withDepartment of Pathology, Harvard Medical School, Massachusetts General Hospital
  • , Virginia A. LiVolsiAffiliated withDepartment of Pathology and Laboratory Medicine, University of Pennsylvania

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The definition of poorly differentiated thyroid carcinoma has been the source of great controversy in the pathology literature.1 Many definitions and schemes have been proposed, but little consensus exists about what defines a poorly differentiated thyroid carcinoma (PDTCA). Because of this, the clinical behavior is not well defined and the clinicopathologic features affecting prognosis remain largely unknown.