Lipid A in Cancer Therapy pp 53-58

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 667)

The Lipid A Receptor

Abstract

The lipid A receptor consists of several subunits. Lipopolysaccharide binding protein (LBP) is a serum protein facilitating association of lipid A with CD14. The Lipid A-LBP-CD14 complex is further delivered to Toll-like receptor 4 (TLR4), which is essential for lipid A-mediated cellular activation. TLR4 associates with MD-2, which is required for surface expression and recognition of lipid A. In addition, the RP 10S-MD-1 complex mediates TLR4-mediated response in B cells and negatively regulates TLR4-mediated response in dendritic cells. Thus, lipid A receptor’s function varies among cell populations.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2009

Authors and Affiliations

  1. 1.Department of Molecular GeneticsMedical Institute of Bioregulation, Kyushu UniversityFukuokaJapan

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