Chapter

The Genetics and Development of Scoliosis

pp 1-20

Date:

Genetic Regulation of Somite and Early Spinal Patterning

  • Kenro KusumiAffiliated withSchool of Life Sciences, Arizona State UniversityDepartment of Basic Medical Sciences, The University of Arizona College of Medicine–Phoenix in Partnership with Arizona State University Email author 
  • , Walter EckalbarAffiliated withSchool of Life Sciences, Arizona State University
  • , Olivier PourquiéAffiliated withDépartement de Biologie Cellulaire et Développement, IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire)Inserm, U964CNRS, UMR7104Université de Strasbourg Email author 

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Abstract

The spine plays an essential biomechanical role, and disruptions to the structure of the vertebral column can have profound clinical consequences. The structure of the spine is patterned early in embryonic development with the formation of transient segmental structures called somites. Developmental studies have helped to identify the genetic pathways regulating this process and the mutations that lead to severe congenital vertebral.