Retinal Degenerative Diseases

Volume 664 of the series Advances in Experimental Medicine and Biology pp 105-114


Multiprotein Complexes of Retinitis Pigmentosa GTPase Regulator (RPGR), a Ciliary Protein Mutated in X-Linked Retinitis Pigmentosa (XLRP)

  • Carlos Murga-ZamalloaAffiliated withDepartment of Ophthalmology and Visual Sciences, Kellogg Eye Center
  • , Anand SwaroopAffiliated withNeurobiology-Neurodegeneration and Repair laboratory (N-NRL), National Eye Institute, National Institutes of Health
  • , Hemant KhannaAffiliated withDepartment of Ophthalmology and Visual Sciences, Kellogg Eye Center Email author 

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Mutations in Retinitis Pigmentosa GTPase Regulator (RPGR) are a frequent cause of X-linked Retinitis Pigmentosa (XLRP). The RPGR gene undergoes extensive alternative splicing and encodes for distinct protein isoforms in the retina. Extensive studies using isoform-specific antibodies and mouse mutants have revealed that RPGR predominantly localizes to the transition zone to primary cilia and associates with selected ciliary and microtubule-associated assemblies in photoreceptors. In this chapter, we have summarized recent advances on understanding the role of RPGR in photoreceptor protein trafficking. We also provide new evidence that suggests the existence of discrete RPGR multiprotein complexes in photoreceptors. Piecing together the RPGR-interactome in different subcellular compartments should provide critical insights into the role of alternative RPGR isoforms in associated orphan and syndromic retinal degenerative diseases.