Modelling of Mitochondrial Oxygen Consumption and NIRS Detection of Cytochrome Oxidase Redox State

  • Murad Banaji
  • Alfred Mallet
  • Clare E. Elwell
  • Peter Nicholls
  • Ilias Tachtsidis
  • Martin Smith
  • Chris E. Cooper
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 662)


In recent years there has been widespread use of near infrared spectroscopy (NIRS) to monitor the brain. The signals of interest include changes in the levels of oxygenated and deoxygenated haemoglobin and tissue oxygen saturation. In addition to oxy- and deoxy-haemoglobin, the CuA centre in cytochrome-c-oxidase (CCO) is a significant NIR absorber, giving rise to another signal termed the ΔoxCCO signal. This signal has great potential as a marker of cellular oxygen metabolism, but is also the hardest to interpret. Here we use a recently constructed model to predict NIRS signal changes, and compare the model output to data from an in vivo hypoxia study in healthy adults. Our findings indicate strongly that the ΔoxCCO signal contains useful information despite the noise, and has responses consistent with the known physiology.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Murad Banaji
    • 1
  • Alfred Mallet
    • 2
  • Clare E. Elwell
    • 3
  • Peter Nicholls
    • 1
  • Ilias Tachtsidis
    • 3
  • Martin Smith
    • 4
  • Chris E. Cooper
    • 5
  1. 1.Department of Biological SciencesUniversity of EssexColchesterUK
  2. 2.Department of Medical Physics and BioengineeringUniversity College LondonLondonUK
  3. 3.Biomedical Optics Research Laboratory, Department of Medical Physics and BioengineeringUniversity College LondonLondonUK
  4. 4.Department of Biological SciencesGreat Ormond Street Hospital for ChildrenLondonUK
  5. 5.Department of Biological Sciences, Centre for Sports and Exercise ScienceUniversity of EssexColchesterUK

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