Functional Optical Topography Analysis Using Statistical Parametric Mapping (SPM) Methodology with and without Physiological Confounds

  • Ilias Tachtsidis
  • Peck H. Koh
  • Charlotte Stubbs
  • Clare E. Elwell
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 662)


Functional optical topography (OT) measures the changes in oxygenated and deoxygenated hemoglobin (HbO2, HHb) across multiple brain sites which occur in response to neuronal activation of the cerebral cortex. However, identification of areas of cortical activation is a complex task due to intrinsic physiological noise and systemic interference and careful statistical analysis is therefore required. A total of 10 young healthy adults were studied. The activation paradigm comprised of anagrams followed by finger tapping. 12 channels of the OT system were positioned over the frontal cortex and 12 channels over the motor cortex while the systemic physiology (mean blood pressure (MBP), heart rate (HR), scalp flux) was simultaneously monitored. Analysis was done using the functional Optical Signal Analysis (fOSA) software and Statistical Parametric Mapping (SPM), where we utilized two approaches: (i) using only HbO2 as a regressor in the general linear model (GLM) and (ii) using all of the explanatory variables (HbO2, MBP, HR and scalp flux) as regressors. Group analysis using SPM showed significant correlation in a large number of OT channels between HbO2 and systemic regressors; however no differences in activation areas were seen between the two approaches.



The authors would like to acknowledge the EPSRC (Grant No EP/D060982/1).


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Ilias Tachtsidis
    • 1
  • Peck H. Koh
    • 1
  • Charlotte Stubbs
    • 1
  • Clare E. Elwell
    • 1
  1. 1.Biomedical Optics Research Laboratory, Department of Medical Physics and BioengineeringUniversity College LondonLondonUK

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