Polysialylation of NCAM

  • Herbert Hildebrandt
  • Martina Mühlenhoff
  • Rita Gerardy-Schahn
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 663)

Abstract

A unique feature of the neural cell adhesion molecule NCAM is that it can be decorated with polysialic acid, a large negatively charged and highly hydrated glycan, which acts as a key regulator of NCAM-mediated and other cell surface interactions. Here, we give a brief overview of the regulation of polysialic acid expression in ontogenesis and tumor development and highlight the interplay of the polysialyltransferases ST8SiaII and ST8SiaIV in implementing the biosynthesis of this unusual carbohydrate polymer. In particular, we focus on recent advances in the separate or combined genetic ablation of the two enzymes, which reveal its vital role in brain development and provide insights into the vigorous control and the structural complexity of NCAM polysialylation.

Keywords

Polysialic acid Neural cell adhesion molecule NCAM Polysialyltransferases Cell surface glycosylation Tumorigenesis Brain development 

Notes

Acknowledgments

The authors thank Deutsche Forschungsgemeinschaft (to RGS, MM, HH), the Deutsche Krebshilfe (to MM and HH), and PROMEMORIA EC FP6 (to RGS) for having given financial support through grants to do this work.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Herbert Hildebrandt
  • Martina Mühlenhoff
  • Rita Gerardy-Schahn
    • 1
  1. 1.Institute of Cellular ChemistryHannover Medical SchoolHannoverGermany

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