The Secretome of Senescent Cells

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Abstract

Cellular senescence is an irreversible proliferation arrest with emerging physiological roles in tumor suppression and tissue wound repair. For example, primary cells that acquire a first oncogenic event often enter cellular senescence and this serves to block their further proliferation and neoplastic transformation. As cells become senescent, the spectrum of factors secreted by those cells changes dramatically. For example, the “secretome” of senescent cells includes increased production of cytokines, matrix metalloproteinases and altered production of many growth factors. This review discusses these factors, their mechanism of regulation in senescent cells and their contribution to the senescent phenotype and its functions.

Keywords

Cellular Senescence Tumor Suppression Cell Senescence Senescent Cell Replicative Senescence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.CRUK Beatson LabsUniversity of GlasgowGlasgowUK

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