Mining Cellular Senescence for Drug Targets

  • Alan E. Bilsland
  • W. Nicol KeithEmail author


One of the fundamental changes required for tumorigenesis is escape from cellular senescence. Strategies to induce senescence in cancer cells might provide future therapies complementary to existing interventions aimed at apoptosis. Progress toward senescence targeted drug discovery could be accelerated by applying novel screening-technologies and in particular, cell-based screening approaches to identifing and validating small molecule agonists/effectors or stabilisers of senescence. In this chapter, we review the molecular bases of cellular senescence from a drug discovery perspective, highlighting existing therapies that induce senescence and strategies to expand the pool of candidate molecular targets.


Telomere Length Malignant Pleural Mesothelioma Accelerate Senescence Senescent Cell Replicative Senescence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



p53-Binding protein 1


Apoptotic peptidase activating factor 1


Anti-silencing factor


Ataxia telangiectasia mutated


Ataxia telangiectasia and Rad3 related


BCL2-associated agonist of cell death


BCL2-antagonist/killer 1


BCL2-associated X protein


B-cell CLL/lymphoma 2


BH3 interacting domain death agonist


Cyclin dependent kinase


Casein kinase 1


Cathelicidin-related antimicrobial protein




Dyskeratosis congenita


DNA dependent protein kinase


DNA methyltransferase 3a


Damage regulated autophagy modulator


Elongation factor 1a


Extracellular signal regulated kinase


Fas-associated via death domain


Fas ligand


Fibroblast growth factor 7


Glycogen synthase kinase 3


HIR histone cell cycle regulation defective homolog A


Heterochromatin proteins 1


Human telomerase reverse transcriptase


Human telomerase RNA component




c-Jun NH3 terminal kinase


Large tumor suppressor, homolog 2


Methyl CpG binding protein 2


Mouse embryonic fibroblast


Mesenchymal stem cell


Mouse telomerase RNA component


Non small cell lung cancer


Proliferating cell nuclear antigen


Phosphoinositide 3-kinase


Protein kinase C


Protection of telomeres 1


p53-Upregulated modulator of apoptosis


Receptor interacting protein kinase


Reactive oxygen species


Senescence-associated heterochromatin foci


Senescence associated β-galactosidase


Telomere dysfunction induced damage foci


TRF1 interacting nuclear factor 2


Tumor necrosis factor α


TIN2 interacting protein 1


TNFRSF1-associated via death domain


TNF-related apoptosis inducing ligand


telomeric repeat binding factors 1&2


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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Centre for Oncology and Applied Pharmacology, Cancer Research UK Beatson LaboratoriesUniversity of GlasgowBearsden, GlasgowUK

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