• Tarik Tihan


Infiltrative and typically benign tumor of peripheral nerves that can occur as a solitary or diffuse mass in the subcutis, soft tissue, or along peripheral nerves. The tumor is believed to consist of a mixture of cell types including schwann cells, perineurial cells, and fibroblasts. Neurofibromas are considered WHO Grade I neoplasms. Some neurofibromas, especially plexiform neurofibromas, often occur in the setting of neurofibromatosis-1 (NF1).


Neurofibroma (localized, diffuse, intraneural, plexiform) Neurofibromin NF1 Schwann cell 

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Tarik Tihan
    • 1
  1. 1.Department of PathologyNeuropathology UnitSan FranciscoUSA

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