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Adenovirus Infection in the Immunocompromised Host

  • Marc Tebruegge
  • Nigel Curtis
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 659)

Abstract

There are 51 known serotypes of human adenovirus, which are divided into subgroups (or species) A to F Table ). An additional serotype (52), which potentially constitutes a new species (G), has recently been reported after genomic sequencing and phylogenetic analysis of an isolate in the U.S.

Keywords

Transplant Recipient Antiviral Therapy Orthotopic Liver Transplant Adenovirus Infection Lung Transplant Recipient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Adeyemia, O.A., Yeldandi, A.V., & Ison, M.G. (2008). Fatal adenovirus pneumonia in a person with AIDS and Burkitt lymphoma: a case report and review of the literature. AIDS Read, (18), 196–198, 201–202, 206–207.Google Scholar
  2. Adeyi, O.A., Randhawa, P.A., Nalesnik, M.A., Ochoa, E.R., Abu-Elmagd, K.M., Demetris, A.J., & Wu, T. (2008). Posttransplant adenoviral enteropathy in patients with small bowel transplantation. Arch Pathol Lab Med, (132), 703–705.PubMedGoogle Scholar
  3. Adrian, T., Schafer, G., Cooney, M.K., Fox, J.P., & Wigand, R. (1988). Persistent enteral infections with adenovirus types 1 and 2 in infants: no evidence of reinfection. Epidemiol Infect, (101), 503–509.PubMedCrossRefGoogle Scholar
  4. Anderson, E.J., Guzman-Cottrill, J.A., Kletzel, M., Thormann, K., Sullivan, C., Zheng, X., & Katz, B.Z. (2008). High-risk adenovirus-infected pediatric allogenic hematopoietic progenitor transplant recipients and preemptive cidofovir therapy. Pediatr Transplant, (12), 219–227.PubMedCrossRefGoogle Scholar
  5. Ardehali, H., Volmar, K., Roberts, C., Forman, M., & Becker, L.C. (2001). Fatal disseminated adenoviral infection in a renal transplant patient. Transplantation, (71), 998–999.PubMedCrossRefGoogle Scholar
  6. Baldwin, A., Kingman, H., Darville, M., Foot, A.B., Grier, D., Cornish, J.M., Goulden, N. et al. (2001). Outcome and clinical course of 100 patients with adenovirus infection following bone marrow transplantation. Bone Marrow Transplant, (26), 1333–1338.CrossRefGoogle Scholar
  7. Bateman, C.M., Kesson, A.M., & Shaw, P.J. (2006). Pancreatitis and adenoviral infection in children after blood and marrow transplantation. Bone Marrow Transplant, (38), 807–811.PubMedCrossRefGoogle Scholar
  8. Bergelson, J.M., Cunningham, J.A., Droguett, G., Kurt-Jones, E.A., Krithivas, A., Hong, J.S., Horwitz, M.S. et al. (1997). Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science, (275), 1320–1323.PubMedCrossRefGoogle Scholar
  9. Berho, M., Torroella, M., Viciana, A., Weppler, D., Thompson, J., Nery, J., Tzakis, A., & Ruiz, P. (1998). Adenovirus enterocolitis in human small bowel transplants. Pediatr Transplant, (2), 277–282.PubMedGoogle Scholar
  10. Bordigoni, P., Carret, A.S., Venard, V., Witz, F., & Le Faou, A. (2001). Treatment of adenovirus infections in patients undergoing allogeneic hematopoietic stem cell transplantation. Clin Infect Dis, (32), 1290–1297.PubMedCrossRefGoogle Scholar
  11. Bruno, B., Gooley, T., Hackman, R.C., Davis, C., Corey, L., & Boeckh, M. (2003). Adenovirus infection in hematopoietic stem cell transplantation: effect of ganciclovir and impact on survival. Biol Blood Marrow Transplant, (9), 341–352.PubMedCrossRefGoogle Scholar
  12. Cames, B., Rahier, J., Burtomboy, G., de Ville de Goyet, J., Reding, R., Lamy, M., Otte, J.B., & Sokal, E.M. (1992). Acute adenovirus hepatitis in liver transplant recipients. J Pediatr, (120), 33–37.Google Scholar
  13. Carter, B.A., Karpen, S.J., Quiros-Tejeira, R.E., Chang, I.F., Clark, B.S., Demmler, G.J., Heslop, H.E. et al. (2002). Intravenous Cidofovir therapy for disseminated adenovirus in a pediatric liver transplant recipient. Transplantation, (74), 1050–1052.PubMedCrossRefGoogle Scholar
  14. Cassano, W.F. (1991). Intravenous ribavirin therapy for adenovirus cystitis after allogeneic bone marrow transplantation. Bone Marrow Transplant, (7), 247–248.PubMedGoogle Scholar
  15. CDC. (2007). Acute respiratory disease associated with adenovirus serotype 14 – four states, 2006–2007. MMWR Morb Mortal Wkly Rep, (56), 1181–1184.Google Scholar
  16. Chakrabarti, S., Collingham, K.E., Fegan, C.D., & Milligan, D.W. (1999). Fulminant adenovirus hepatitis following unrelated bone marrow transplantation: failure of intravenous ribavirin therapy. Bone Marrow Transplant, (23), 1209–1211.PubMedCrossRefGoogle Scholar
  17. Chakrabarti, S., Mautner, V., Osman, H., Collingham, K.E., Fegan, C.D., Klapper, P.E., Moss, P.A. et al. (2002). Adenovirus infections following allogeneic stem cell transplantation: incidence and outcome in relation to graft manipulation, immunosuppression, and immune recovery. Blood, (100), 1619–1627.PubMedCrossRefGoogle Scholar
  18. Claas, E.C., Schilham, M.W., de Brouwer, C.S., Hubacek, P., Echavarria, M., Lankester, A.C., van Tol, M.J. et al. (2005). Internally controlled real-time PCR monitoring of adenovirus DNA load in serum or plasma of transplant recipients. J Clin Microbiol, (43), 1738–1744.PubMedCrossRefGoogle Scholar
  19. Dagan, R., Schwartz, R.H., Insel, R.A., & Menegus, M.A. (1984). Severe diffuse adenovirus 7a pneumonia in a child with combined immunodeficiency: possible therapeutic effect of human immune serum globulin containing specific neutralizing antibody. Pediatr Infect Dis, (3), 246–251.PubMedCrossRefGoogle Scholar
  20. De Clercq, E. (2003). Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections. Clin Microbiol Rev, (16), 569–596.PubMedCrossRefGoogle Scholar
  21. De Clercq, E., Andrei, G., Balzarini, J., Leyssen, P., Naesens, L., Neyts, J., Pannecouque, C. et al. (2005). Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines. Nucleosides Nucleotides Nucleic Acids, (24), 331–341.PubMedCrossRefGoogle Scholar
  22. de Mezerville, M.H., Tellier, R., Richardson, S., Hebert, D., Doyle, J., & Allen, U. (2006). Adenoviral infections in pediatric transplant recipients: a hospital-based study. Pediatr Infect Dis J, (25), 815–818.PubMedCrossRefGoogle Scholar
  23. de Oliveira, C.B., Stevenson, D., LaBree, L., McDonnell, P.J., & Trousdale, M.D. (1996). Evaluation of Cidofovir (HPMPC, GS-504) against adenovirus type 5 infection in vitro and in a New Zealand rabbit ocular model. Antiviral Res, (31), 165–172.PubMedCrossRefGoogle Scholar
  24. Doan, M.L., Mallory, G.B., Kaplan, S.L., Dishop, M.K., Schecter, M.G., McKenzie, E.D., Heinle, J.S. et al. (2007). Treatment of adenovirus pneumonia with cidofovir in pediatric lung transplant recipients. J Heart Lung Transplant, (26), 883–889.PubMedCrossRefGoogle Scholar
  25. Echavarria, M., Forman, M., Ticehurst, J., Dumler, J.S., & Charache, P. (1998). PCR method for detection of adenovirus in urine of healthy and human immunodeficiency virus-infected individuals. J Clin Microbiol, (36), 3323–3326.PubMedGoogle Scholar
  26. Echavarria, M., Forman, M., van Tol, M.J., Vossen, J.M., Charache, P., & Kroes, A.C. (2001). Prediction of severe disseminated adenovirus infection by serum PCR. Lancet, (358), 384–385.PubMedCrossRefGoogle Scholar
  27. Edwards, K.M., Thompson, J., Paolini, J., & Wright, P.F. (1985). Adenovirus infections in young children. Pediatrics, (76), 420–424.PubMedGoogle Scholar
  28. El-Sayed Zaki, M. & Abd-El Fatah, G.A. (2008). Rapid detection of oculopathogenic adenovirus in conjunctivitis. Curr Microbiol, (56), 105–109.PubMedCrossRefGoogle Scholar
  29. Emovon, O.E., Lin, A., Howell, D.N., Afzal, F., Baillie, M., Rogers, J., Baliga, P. et al. (2003). Refractory adenovirus infection after simultaneous kidney-pancreas transplantation: successful treatment with intravenous ribavirin and pooled human intravenous immunoglobulin. Nephrol Dial Transplant, (18), 2436–2438.PubMedCrossRefGoogle Scholar
  30. Erard, V., Huang, M.L., Ferrenberg, J., Nguy, L., Stevens-Ayers, T.L., Hackman, R.C., Corey, L. et al. (2007). Quantitative real-time polymerase chain reaction for detection of adenovirus after T cell-replete hematopoietic cell transplantation: viral load as a marker for invasive disease. Clin Infect Dis, (45), 958–965.PubMedCrossRefGoogle Scholar
  31. Espy, M.J., Hierholzer, J.C., & Smith, T.F. (1987). The effect of centrifugation on the rapid detection of adenovirus in shell vials. Am J Clin Pathol, (88), 358–360.PubMedGoogle Scholar
  32. Feuchtinger, T., Lang, P., & Handgretinger, R. (2007). Adenovirus infection after allogeneic stem cell transplantation. Leuk Lymphoma, (48), 244–255.PubMedCrossRefGoogle Scholar
  33. Feuchtinger, T., Matthes-Martin, S., Richard, C., Lion, T., Fuhrer, M., Hamprecht, K., Handgretinger, R., Peters, C. et al. (2006). Safe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation. Br J Haematol, (134), 64–76.PubMedCrossRefGoogle Scholar
  34. Fianchi, L., Scardocci, A., Cattani, P., Tartaglione, T., & Pagano, L. (2003). Adenovirus meningoencephalitis in a patient with large B-cell lymphoma. Ann Hematol, (82), 313–315.PubMedGoogle Scholar
  35. Flomenberg, P., Babbitt, J., Drobyski, W.R., Ash, R.C., Carrigan, D.R., Sedmak, G.V., McAuliffe, T. et al. (1994). Increasing incidence of adenovirus disease in bone marrow transplant recipients. J Infect Dis, (169), 775–781.PubMedGoogle Scholar
  36. Fox, J.P., Brandt, C.D., Wassermann, F.E., Hall, C.E., Spigland, I., Kogon, A., & Elveback, L.R. (1969). The virus watch program: a continuing surveillance of viral infections in metropolitan New York families. VI. Observations of adenovirus infections: virus excretion patterns, antibody response, efficiency of surveillance, patterns of infections, and relation to illness. Am J Epidemiol, (89), 25–50.PubMedGoogle Scholar
  37. Freymuth, F., Vabret, A., Cuvillon-Nimal, D., Simon, S., Dina, J., Legrand, L., Gouarin, S. et al. (2006). Comparison of multiplex PCR assays and conventional techniques for the diagnostic of respiratory virus infections in children admitted to hospital with an acute respiratory illness. J Med Virol, (78), 1498–1504.PubMedCrossRefGoogle Scholar
  38. Gardner, P.S. (1968). Virus infections and respiratory disease of childhood. Arch Dis Child, (43), 629–645.PubMedCrossRefGoogle Scholar
  39. Garnett, C.T., Erdman, D., Xu, W., & Gooding, L.R. (2002). Prevalence and quantitation of species C adenovirus DNA in human mucosal lymphocytes. J Virol, (76), 10608–10616.PubMedCrossRefGoogle Scholar
  40. Greber, U.F., Suomalainen, M., Stidwill, R.P., Boucke, K., Ebersold, M.W., & Helenius, A. (1997). The role of the nuclear pore complex in adenovirus DNA entry. Embo J, (16), 5998–6007.PubMedCrossRefGoogle Scholar
  41. Greber, U.F., Willetts, M., Webster, P., & Helenius, A. (1993). Stepwise dismantling of adenovirus 2 during entry into cells. Cell, (75), 477–486.PubMedCrossRefGoogle Scholar
  42. Hale, G.A., Heslop, H.E., Krance, R.A., Brenner, M.A., Jayawardene, D., Srivastava, D.K., & Patrick, C.C. (1999). Adenovirus infection after pediatric bone marrow transplantation. Bone Marrow Transplant, (23), 277–282.PubMedCrossRefGoogle Scholar
  43. Hatakeyama, N., Suzuki, N., Kudoh, T., Hori, T., Mizue, N., & Tsutsumi, H. (2003). Successful cidofovir treatment of adenovirus-associated hemorrhagic cystitis and renal dysfunction after allogenic bone marrow transplant. Pediatr Infect Dis J, (22), 928–929.PubMedCrossRefGoogle Scholar
  44. Hedderwick, S.A., Greenson, J.K., McGaughy, V.R., & Clark, N.M. (1998). Adenovirus cholecystitis in a patient with AIDS. Clin Infect Dis, (26), 997–999.PubMedCrossRefGoogle Scholar
  45. Heemskerk, B., Lankester, A.C., van Vreeswijk, T., Beersma, M.F., Claas, E.C., Veltrop-Duits, L.A., Kroes, A.C. et al. (2005). Immune reconstitution and clearance of human adenovirus viremia in pediatric stem-cell recipients. J Infect Dis, (191), 520–530.PubMedCrossRefGoogle Scholar
  46. Hierholzer, J.C. (1992). Adenoviruses in the immunocompromised host. Clin Microbiol Rev, (5), 262–274.PubMedGoogle Scholar
  47. Hillenkamp, J., Reinhard, T., Ross, R.S., Bohringer, D., Cartsburg, O., Roggendorf, M., De Clercq, E. et al. (2001). Topical treatment of acute adenoviral keratoconjunctivitis with 0.2% cidofovir and 1% cyclosporine: a controlled clinical pilot study. Arch Ophthalmol, (119), 1487–1491.PubMedGoogle Scholar
  48. Hillenkamp, J., Reinhard, T., Ross, R.S., Bohringer, D., Cartsburg, O., Roggendorf, M., De Clercq, E. et al. (2002). The effects of cidofovir 1% with and without cyclosporin a 1% as a topical treatment of acute adenoviral keratoconjunctivitis: a controlled clinical pilot study. Ophthalmology, (109), 845–850.PubMedCrossRefGoogle Scholar
  49. Hoffman, J.A. (2006). Adenoviral disease in pediatric solid organ transplant recipients. Pediatr Transplant, (10), 17–25.PubMedCrossRefGoogle Scholar
  50. Hoffman, J.A., Shah, A.J., Ross, L.A., & Kapoor, N. (2001). Adenoviral infections and a prospective trial of cidofovir in pediatric hematopoietic stem cell transplantation. Biol Blood Marrow Transplant, (7), 388–394.PubMedCrossRefGoogle Scholar
  51. Hofland, C.A., Eron, L.J., & Washecka, R.M. (2004). Hemorrhagic adenovirus cystitis after renal transplantation. Transplant Proc, (36), 3025–3027.PubMedCrossRefGoogle Scholar
  52. Hong, J.Y., Lee, H.J., Piedra, P.A., Choi, E.H., Park, K.H., Koh, Y.Y., & Kim, W.S. (2001). Lower respiratory tract infections due to adenovirus in hospitalized Korean children: epidemiology, clinical features, and prognosis. Clin Infect Dis, (32), 1423–1429.PubMedCrossRefGoogle Scholar
  53. Hough, R., Chetwood, A., Sinfield, R., Welch, J., & Vora, A. (2005). Fatal adenovirus hepatitis during standard chemotherapy for childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol, (27), 67–72.PubMedCrossRefGoogle Scholar
  54. Howard, D.S., Phillips, I.G., Reece, D.E., Munn, R.K., Henslee-Downey, J., Pittard, M., Barker, M. et al. (1999). Adenovirus infections in hematopoietic stem cell transplant recipients. Clin Infect Dis, (29), 1494–1501.PubMedCrossRefGoogle Scholar
  55. Hromas, R., Clark, C., Blanke, C., Tricot, G., Cornetta, K., Hedderman, A., & Broun, E.R. (1994a). Failure of ribavirin to clear adenovirus infections in T cell-depleted allogeneic bone marrow transplantation. Bone Marrow Transplant, (14), 663–664.PubMedGoogle Scholar
  56. Hromas, R., Cornetta, K., Srour, E., Blanke, C., & Broun, E.R. (1994b). Donor leukocyte infusion as therapy of life-threatening adenoviral infections after T-cell-depleted bone marrow transplantation. Blood, (84), 1689–1690.PubMedGoogle Scholar
  57. Humar, A., Kumar, D., Mazzulli, T., Razonable, R.R., Moussa, G., Paya, C.V., Covington, E. et al. (2005). A surveillance study of adenovirus infection in adult solid organ transplant recipients. Am J Transplant, (5), 2555–2559.PubMedCrossRefGoogle Scholar
  58. Ison, M.G. (2006). Adenovirus infections in transplant recipients. Clin Infect Dis, (43), 331–339.PubMedCrossRefGoogle Scholar
  59. Jones, M.S., 2nd, Harrach, B., Ganac, R.D., Gozum, M.M., Dela Cruz, W.P., Riedel, B., Pan, C. et al (2007). New adenovirus species found in a patient presenting with gastroenteritis. J Virol, (81), 5978–5984.PubMedCrossRefGoogle Scholar
  60. Kalpoe, J.S., van der Heiden, P.L., Barge, R.M., Houtzager, S., Lankester, A.C., van Tol, M.J., & Kroes, A.C. (2007). Assessment of disseminated adenovirus infections using quantitative plasma PCR in adult allogeneic stem cell transplant recipients receiving reduced intensity or myeloablative conditioning. Eur J Haematol, (78), 314–321.PubMedCrossRefGoogle Scholar
  61. Kampmann, B., Cubitt, D., Walls, T., Naik, P., Depala, M., Samarasinghe, S., Robson, D., Hassan, A. et al. (2005). Improved outcome for children with disseminated adenoviral infection following allogeneic stem cell transplantation. Br J Haematol, (130), 595–603.PubMedCrossRefGoogle Scholar
  62. Kawakami, M., Ueda, S., Maeda, T., Karasuno, T., Teshima, H., Hiraoka, A., Nakamura, H. et al. (1997). Vidarabine therapy for virus-associated cystitis after allogeneic bone marrow transplantation. Bone Marrow Transplant, (20), 485–490.PubMedCrossRefGoogle Scholar
  63. Keswani, M. & Moudgil, A. (2007). Adenovirus-associated hemorrhagic cystitis in a pediatric renal transplant recipient. Pediatr Transplant, (11), 568–571.PubMedCrossRefGoogle Scholar
  64. Kim, M.R., Lee, H.R., & Lee, G.M. (2000). Epidemiology of acute viral respiratory tract infections in Korean children. J Infect, (41), 152–158.PubMedCrossRefGoogle Scholar
  65. Kinchington, P.R., Araullo-Cruz, T., Vergnes, J.P., Yates, K., & Gordon, Y.J. (2002). Sequence changes in the human adenovirus type 5 DNA polymerase associated with resistance to the broad spectrum antiviral cidofovir. Antiviral Res, (56), 73–84.PubMedCrossRefGoogle Scholar
  66. Kitabayashi, A., Hirokawa, M., Kuroki, J., Nishinari, T., Niitsu, H., & Miura, A.B. (1994). Successful vidarabine therapy for adenovirus type 11-associated acute hemorrhagic cystitis after allogeneic bone marrow transplantation. Bone Marrow Transplant, (14), 853–854.PubMedGoogle Scholar
  67. Kojaoghlanian, T., Flomenberg, P., & Horwitz, M.S. (2003). The impact of adenovirus infection on the immunocompromised host. Rev Med Virol, (13), 155–171.PubMedCrossRefGoogle Scholar
  68. Koneru, B., Jaffe, R., Esquivel, C.O., Kunz, R., Todo, S., Iwatsuki, S., & Starzl, T.E. (1987). Adenoviral infections in pediatric liver transplant recipients. Jama, (258), 489–492.PubMedGoogle Scholar
  69. Kurosaki, K., Miwa, N., Yoshida, Y., Kurokawa, M., Kurimoto, M., Endo, S., & Shiraki, K. (2004). Therapeutic basis of vidarabine on adenovirus-induced haemorrhagic cystitis. Antivir Chem Chemother, (15), 281–285.PubMedGoogle Scholar
  70. La Rosa, A.M., Champlin, R.E., Mirza, N., Gajewski, J., Giralt, S., Rolston, K.V., Raad, I. et al. (2001). Adenovirus infections in adult recipients of blood and marrow transplants. Clin Infect Dis, (32), 871–876.PubMedCrossRefGoogle Scholar
  71. Lankester, A.C., Heemskerk, B., Claas, E.C., Schilham, M.W., Beersma, M.F., Bredius, R.G., van Tol, M.J. et al. (2004). Effect of ribavirin on the plasma viral DNA load in patients with disseminating adenovirus infection. Clin Infect Dis, (38), 1521–1525.PubMedCrossRefGoogle Scholar
  72. Lankester, A.C., van Tol, M.J., Claas, E.C., Vossen, J.M., & Kroes, A.C. (2002). Quantification of adenovirus DNA in plasma for management of infection in stem cell graft recipients. Clin Infect Dis, (34), 864–867.PubMedCrossRefGoogle Scholar
  73. Leen, A.M., Myers, G.D., Bollard, C.M., Huls, M.H., Sili, U., Gee, A.P., Heslop, H.E. et al. (2005). T-cell immunotherapy for adenoviral infections of stem-cell transplant recipients. Ann N Y Acad Sci, (1062), 104–115.PubMedCrossRefGoogle Scholar
  74. Leen, A.M., Myers, G.D., Sili, U., Huls, M.H., Weiss, H., Leung, K.S., Carrum, G. et al. (2006). Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals. Nat Med, (12), 1160–1166.PubMedCrossRefGoogle Scholar
  75. Lenaerts, L., Verbeken, E., De Clercq, E., & Naesens, L. (2005). Mouse adenovirus type 1 infection in SCID mice: an experimental model for antiviral therapy of systemic adenovirus infections. Antimicrob Agents Chemother, (49), 4689–4699.PubMedCrossRefGoogle Scholar
  76. Leruez-Ville, M., Chardin-Ouachee, M., Neven, B., Picard, C., Le Guinche, I., Fischer, A., Rouzioux, C. et al. (2006). Description of an adenovirus A31 outbreak in a paediatric haematology unit. Bone Marrow Transplant, (38), 23–28.PubMedCrossRefGoogle Scholar
  77. Leruez-Ville, M., Minard, V., Lacaille, F., Buzyn, A., Abachin, E., Blanche, S., Freymuth, F. et al. (2004). Real-time blood plasma polymerase chain reaction for management of disseminated adenovirus infection. Clin Infect Dis, (38), 45–52.PubMedCrossRefGoogle Scholar
  78. Leung, A.Y., Chan, M., Cheng, V.C., Yuen, K.Y., & Kwong, Y.L. (2005). Quantification of adenovirus in the lower respiratory tract of patients without clinical adenovirus-related respiratory disease. Clin Infect Dis, (40), 1541–1544.PubMedCrossRefGoogle Scholar
  79. Liles, W.C., Cushing, H., Holt, S., Bryan, C., & Hackman, R.C. (1993). Severe adenoviral nephritis following bone marrow transplantation: successful treatment with intravenous ribavirin. Bone Marrow Transplant, (12), 409–412.PubMedGoogle Scholar
  80. Lion, T., Baumgartinger, R., Watzinger, F., Matthes-Martin, S., Suda, M., Preuner, S., Futterknecht, B. et al. (2003). Molecular monitoring of adenovirus in peripheral blood after allogeneic bone marrow transplantation permits early diagnosis of disseminated disease. Blood, (102), 1114–1120.PubMedCrossRefGoogle Scholar
  81. Ljungman, P., Ribaud, P., Eyrich, M., Matthes-Martin, S., Einsele, H., Bleakley, M., Machaczka, M. et al. (2003). Cidofovir for adenovirus infections after allogeneic hematopoietic stem cell transplantation: a survey by the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant, (31), 481–486.PubMedCrossRefGoogle Scholar
  82. Louie, J.K., Kajon, A.E., Holodniy, M., Guardia-LaBar, L., Lee, B., Petru, A.M., Hacker, J.K. et al. (2008). Severe pneumonia due to adenovirus serotype 14: a new respiratory threat? Clin Infect Dis, (46), 421–425.PubMedCrossRefGoogle Scholar
  83. Mahafzah, A.M. & Landry, M.L. (1989). Evaluation of immunofluorescent reagents, centrifugation, and conventional cultures for the diagnosis of adenovirus infection. Diagn Microbiol Infect Dis, (12), 407–411.PubMedCrossRefGoogle Scholar
  84. Mann, D., Moreb, J., Smith, S., & Gian, V. (1998). Failure of intravenous ribavirin in the treatment of invasive adenovirus infection following allogeneic bone marrow transplantation: a case report. J Infect, (36), 227–228.Google Scholar
  85. Maslo, C., Girard, P.M., Urban, T., Guessant, S., & Rozenbaum, W. (1997). Ribavirin therapy for adenovirus pneumonia in an AIDS patient. Am J Respir Crit Care Med, (156), 1263–1264.PubMedGoogle Scholar
  86. Matar, L.D., McAdams, H.P., Palmer, S.M., Howell, D.N., Henshaw, N.G., Davis, R.D., & Tapson, V.F. (1999). Respiratory viral infections in lung transplant recipients: radiologic findings with clinical correlation. Radiology, (213), 735–742.PubMedGoogle Scholar
  87. McGrath, D., Falagas, M.E., Freeman, R., Rohrer, R., Fairchild, R., Colbach, C., & Snydman, D.R. (1998). Adenovirus infection in adult orthotopic liver transplant recipients: incidence and clinical significance. J Infect Dis, (177), 459–462.PubMedCrossRefGoogle Scholar
  88. Medina-Kauwe, L.K. (2003). Endocytosis of adenovirus and adenovirus capsid proteins. Adv Drug Deliv Rev, (55), 1485–1496.PubMedCrossRefGoogle Scholar
  89. Mentel, R., Kinder, M., Wegner, U., von Janta-Lipinski, M., & Matthes, E. (1997). Inhibitory activity of 3’-fluoro-2’ deoxythymidine and related nucleoside analogues against adenoviruses in vitro. Antiviral Res, (34), 113–119.PubMedCrossRefGoogle Scholar
  90. Mentel, R. & Wegner, U. (2000). Evaluation of the efficacy of 2’,3’-dideoxycytidine against adenovirus infection in a mouse pneumonia model. Antiviral Res, (47), 79–87.PubMedCrossRefGoogle Scholar
  91. Michaels, M.G., Green, M., Wald, E.R., & Starzl, T.E. (1992). Adenovirus infection in pediatric liver transplant recipients. J Infect Dis, (165), 170–174.PubMedGoogle Scholar
  92. Morfin, F., Dupuis-Girod, S., Mundweiler, S., Falcon, D., Carrington, D., Sedlacek, P., Bierings, M. et al. (2005). In vitro susceptibility of adenovirus to antiviral drugs is species-dependent. Antivir Ther, (10), 225–229.PubMedGoogle Scholar
  93. Muller, W.J., Levin, M.J., Shin, Y.K., Robinson, C., Quinones, R., Malcolm, J., Hild, E. et al. (2005). Clinical and in vitro evaluation of cidofovir for treatment of adenovirus infection in pediatric hematopoietic stem cell transplant recipients. Clin Infect Dis, (41), 1812–1816.PubMedCrossRefGoogle Scholar
  94. Murphy, G.F., Wood, D.P., Jr., McRoberts, J.W., & Henslee-Downey, P.J. (1993). Adenovirus-associated hemorrhagic cystitis treated with intravenous ribavirin. J Urol, (149), 565–566.PubMedGoogle Scholar
  95. Myerowitz, R.L., Stalder, H., Oxman, M.N., Levin, M.J., Moore, M., Leith, J.D., Gantz, N.M. et al. (1975). Fatal disseminated adenovirus infection in a renal transplant recipient. Am J Med, (59), 591–598.PubMedCrossRefGoogle Scholar
  96. Naesens, L., Lenaerts, L., Andrei, G., Snoeck, R., Van Beers, D., Holy, A., Balzarini, J. et al. (2005). Antiadenovirus activities of several classes of nucleoside and nucleotide analogues. Antimicrob Agents Chemother, (49), 1010–1016.PubMedCrossRefGoogle Scholar
  97. Nagafuji, K., Aoki, K., Henzan, H., Kato, K., Miyamoto, T., Eto, T., Nagatoshi, Y. et al. (2004). Cidofovir for treating adenoviral hemorrhagic cystitis in hematopoietic stem cell transplant recipients. Bone Marrow Transplant, (34), 909–914.PubMedCrossRefGoogle Scholar
  98. Nebbia, G., Chawla, A., Schutten, M., Atkinson, C., Raza, M., Johnson, M., & Geretti, A. (2005). Adenovirus viraemia and dissemination unresponsive to antiviral therapy in advanced HIV-1 infection. Aids, (19), 1339–1340.PubMedCrossRefGoogle Scholar
  99. Nemerow, G.R., Cheresh, D.A., & Wickham, T.J. (1994). Adenovirus entry into host cells: a role for alpha(v) integrins. Trends Cell Biol, (4), 52–55.PubMedCrossRefGoogle Scholar
  100. Neofytos, D., Ojha, A., Mookerjee, B., Wagner, J., Filicko, J., Ferber, A., Dessain, S. et al. (2007). Treatment of adenovirus disease in stem cell transplant recipients with cidofovir. Biol Blood Marrow Transplant, (13), 74–81.PubMedCrossRefGoogle Scholar
  101. Pacini, D.L., Collier, A.M., & Henderson, F.W. (1987). Adenovirus infections and respiratory illnesses in children in group day care. J Infect Dis, (156), 920–927.PubMedGoogle Scholar
  102. Palmer, S.M., Jr., Henshaw, N.G., Howell, D.N., Miller, S.E., Davis, R.D., & Tapson, V.F. (1998). Community respiratory viral infection in adult lung transplant recipients. Chest, (113), 944–950.PubMedCrossRefGoogle Scholar
  103. Parizhskaya, M., Walpusk, J., Mazariegos, G., & Jaffe, R. (2001). Enteric adenovirus infection in pediatric small bowel transplant recipients. Pediatr Dev Pathol, (4), 122–128.PubMedCrossRefGoogle Scholar
  104. Pinchoff, R.J., Kaufman, S.S., Magid, M.S., Erdman, D.D., Gondolesi, G.E., Mendelson, M.H., Tane, K. et al. (2003). Adenovirus infection in pediatric small bowel transplantation recipients. Transplantation, (76), 183–189.PubMedCrossRefGoogle Scholar
  105. Rocholl, C., Gerber, K., Daly, J., Pavia, A.T., & Byington, C.L. (2004). Adenoviral infections in children: the impact of rapid diagnosis. Pediatrics, (113), e51–e56.PubMedCrossRefGoogle Scholar
  106. Romanowski, E.G., Yates, K.A., & Gordon, Y.J. (2001). Antiviral prophylaxis with twice daily topical cidofovir protects against challenge in the adenovirus type 5/New Zealand rabbit ocular model. Antiviral Res, (52), 275–280.PubMedCrossRefGoogle Scholar
  107. Rosario, R.F., Kimbrough, R.C., Van Buren, D.H., & Laski, M.E. (2006). Fatal adenovirus serotype-5 in a deceased-donor renal transplant recipient. Transpl Infect Dis, (8), 54–57.PubMedCrossRefGoogle Scholar
  108. Runde, V., Ross, S., Trenschel, R., Lagemann, E., Basu, O., Renzing-Kohler, K., Schaefer, U.W. et al. (2001). Adenoviral infection after allogeneic stem cell transplantation (SCT): report on 130 patients from a single SCT unit involved in a prospective multi center surveillance study. Bone Marrow Transplant, (28), 51–57.Google Scholar
  109. Sabroe, I., McHale, J., Tait, D.R., Lynn, W.A., Ward, K.N., & Shaunak, S. (1995). Treatment of adenoviral pneumonitis with intravenous ribavirin and immunoglobulin. Thorax, (50), 1219–1220.PubMedCrossRefGoogle Scholar
  110. Safrin, S., Cherrington, J., & Jaffe, H.S. (1997). Clinical uses of cidofovir. Rev Med Virol, (7), 145–156.PubMedCrossRefGoogle Scholar
  111. Schilham, M.W., Claas, E.C., van Zaane, W., Heemskerk, B., Vossen, J.M., Lankester, A.C., Toes, R.E. et al. (2002). High levels of adenovirus DNA in serum correlate with fatal outcome of adenovirus infection in children after allogeneic stem-cell transplantation. Clin Infect Dis, (35), 526–532.PubMedCrossRefGoogle Scholar
  112. Schowengerdt, K.O., Ni, J., Denfield, S.W., Gajarski, R.J., Radovancevic, B., Frazier, H.O., Demmler, G.J. et al. (1996). Diagnosis, surveillance, and epidemiologic evaluation of viral infections in pediatric cardiac transplant recipients with the use of the polymerase chain reaction. J Heart Lung Transplant, (15), 111–123.PubMedGoogle Scholar
  113. Seidel, M.G., Kastner, U., Minkov, M., & Gadner, H. (2003). IVIG treatment of adenovirus infection-associated macrophage activation syndrome in a two-year-old boy: case report and review of the literature. Pediatr Hematol Oncol, (20), 445–451.Google Scholar
  114. Seidemann, K., Heim, A., Pfister, E.D., Koditz, H., Beilken, A., Sander, A., Melter, M. et al. (2004). Monitoring of adenovirus infection in pediatric transplant recipients by quantitative PCR: report of six cases and review of the literature. Am J Transplant, (4), 2102–2108.Google Scholar
  115. Seth, P. (1994). Adenovirus-dependent release of choline from plasma membrane vesicles at an acidic pH is mediated by the penton base protein. J Virol, (68), 1204–1206.PubMedGoogle Scholar
  116. Shields, A.F., Hackman, R.C., Fife, K.H., Corey, L., & Meyers, J.D. (1985). Adenovirus infections in patients undergoing bone-marrow transplantation. N Engl J Med, (312), 529–533.PubMedCrossRefGoogle Scholar
  117. Shirali, G.S., Ni, J., Chinnock, R.E., Johnston, J.K., Rosenthal, G.L., Bowles, N.E., & Towbin, J.A. (2001). Association of viral genome with graft loss in children after cardiac transplantation. N Engl J Med, (344), 1498–1503.PubMedCrossRefGoogle Scholar
  118. Sivaprakasam, P., Carr, T.F., Coussons, M., Khalid, T., Bailey, A.S., Guiver, M., Mutton, K.J. et al. (2007). Improved outcome from invasive adenovirus infection in pediatric patients after hemopoietic stem cell transplantation using intensive clinical surveillance and early intervention. J Pediatr Hematol Oncol, (29), 81–85.PubMedCrossRefGoogle Scholar
  119. Steiner, I., Aebi, C., Ridolfi Luthy, A., Wagner, B., & Leibundgut, K. (2008). Fatal adenovirus hepatitis during maintenance therapy for childhood acute lymphoblastic leukemia. Pediatr Blood Cancer, (50), 647–649.PubMedCrossRefGoogle Scholar
  120. Symeonidis, N., Jakubowski, A., Pierre-Louis, S., Jaffe, D., Pamer, E., Sepkowitz, K., O’Reilly, R.J. et al. (2007). Invasive adenoviral infections in T-cell-depleted allogeneic hematopoietic stem cell transplantation: high mortality in the era of cidofovir. Transpl Infect Dis, (9), 108–113.PubMedCrossRefGoogle Scholar
  121. Uchio, E., Fuchigami, A., Kadonosono, K., Hayashi, A., Ishiko, H., Aoki, K., & Ohno, S. (2007). Anti-adenoviral effect of anti-HIV agents in vitro in serotypes inducing keratoconjunctivitis. Graefes Arch Clin Exp Ophthalmol, (245), 1319–1325.PubMedCrossRefGoogle Scholar
  122. van Tol, M.J., Kroes, A.C., Schinkel, J., Dinkelaar, W., Claas, E.C., Jol-van der Zijde, C.M. et al. (2005). Adenovirus infection in paediatric stem cell transplant recipients: increased risk in young children with a delayed immune recovery. Bone Marrow Transplant, (36), 39–50.PubMedCrossRefGoogle Scholar
  123. Wallot, M.A., Dohna-Schwake, C., Auth, M., Nadalin, S., Fiedler, M., Malago, M., Broelsch, C. et al. (2006). Disseminated adenovirus infection with respiratory failure in pediatric liver transplant recipients: impact of intravenous cidofovir and inhaled nitric oxide. Pediatr Transplant, (10), 121–127.PubMedCrossRefGoogle Scholar
  124. Walls, T., Hawrami, K., Ushiro-Lumb, I., Shingadia, D., Saha, V., & Shankar, A.G. (2005). Adenovirus infection after pediatric bone marrow transplantation: is treatment always necessary? Clin Infect Dis, (40), 1244–1249.PubMedCrossRefGoogle Scholar
  125. Walls, T., Shankar, A.G., & Shingadia, D. (2003). Adenovirus: an increasingly important pathogen in paediatric bone marrow transplant patients. Lancet Infect Dis, (3), 79–86.PubMedCrossRefGoogle Scholar
  126. Wickham, T.J., Mathias, P., Cheresh, D.A., & Nemerow, G.R. (1993). Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment. Cell, (73), 309–319.PubMedCrossRefGoogle Scholar
  127. Wigger, H.J. & Blanc, W.A. (1966). Fatal hepatic and bronchial necrosis in adenovirus infection with thymic alymphoplasia. N Engl J Med, (275), 870–874.PubMedCrossRefGoogle Scholar
  128. Wong, S., Pabbaraju, K., Pang, X.L., Lee, B.E., & Fox, J.D. (2008). Detection of a broad range of human adenoviruses in respiratory tract samples using a sensitive multiplex real-time PCR assay. J Med Virol, (80), 856–865.PubMedCrossRefGoogle Scholar
  129. Wulffraat, N.M., Geelen, S.P., van Dijken, P.J., de Graeff-Meeder, B., Kuis, W., & Boven, K. (1995). Recovery from adenovirus pneumonia in a severe combined immunodeficiency patient treated with intravenous ribavirin. Transplantation, (59), 927.PubMedGoogle Scholar
  130. Yusuf, U., Hale, G.A., Carr, J., Gu, Z., Benaim, E., Woodard, P., Kasow, K.A. et al. (2006). Cidofovir for the treatment of adenoviral infection in pediatric hematopoietic stem cell transplant patients. Transplantation, (81), 1398–1404.PubMedCrossRefGoogle Scholar
  131. Ziring, D., Tran, R., Edelstein, S., McDiarmid, S.V., Gajjar, N., Cortina, G., Vargas, J. et al. (2005). Infectious enteritis after intestinal transplantation: incidence, timing, and outcome. Transplantation, (79), 702–709.PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of Paediatrics, Department of General Medicine; Microbiology & Infectious Diseases Research Group, Murdoch Children’s Research Institute: Infectious Diseases UnitThe University of Melbourne; Royal Children’s Hospital MelbourneParkvilleAustralia

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