Agent-Based Modeling of Ductal Carcinoma In Situ: Application to Patient-Specific Breast Cancer Modeling

  • Paul Macklin
  • Jahun Kim
  • Giovanna Tomaiuolo
  • Mary E. Edgerton
  • Vittorio Cristini
Chapter

Abstract

Ductal carcinoma in situ (DCIS) of the breast is the most common precursor to invasive carcinoma (IC), the second-leading cause of death in women in USA. There has been great progress in modeling DCIS at both the cellular scale (e.g., using cellular automata and agent-based models) and the population scale (e.g., using partial differential equations or systems of ordinary differential equations), but these past efforts have been difficult to calibrate with patient-specific molecular and cellular measurements. We develop a biophysically justified, agent-based cellular model of DCIS that is well-suited to patient-specific calibration. The model is modular in nature and can thus be readily extended to incorporate more advanced biology. We give an example of recently developed, patient-specific calibration of the model and conduct parameter studies that generate testable biological hypotheses.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Paul Macklin
    • 1
  • Jahun Kim
  • Giovanna Tomaiuolo
  • Mary E. Edgerton
  • Vittorio Cristini
  1. 1.School of Health Information SciencesUniversity of Texas Health Science CenterHoustonUSA

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