Cooperation and Cancer

  • Kathleen Sprouffske
  • Carlo C. MaleyEmail author
Part of the Cancer Genetics book series (CANGENETICS)


The preceding chapters detail how mutations in genes such as PDGFB, CDH1, TGFBR1, KRAS shape tumor microenvironment. Chapter 19 further demonstrates that multiple mutations targeting parallel pathways readily occur in the same tumor. Do they arise and function independently or do they interact, coevolve, and influence tumor progression in concert? Some answers to this broad question could be found in the concluding chapter of the volume.


Neoplastic Cell Multicellular Organism Evolutionary Stable Strategy Squamous Cell Carcinoma Cell Somatic Evolution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Genomics & Computational Biology Graduate GroupUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Department of Cellular and Molecular Oncology, Wister InstitutePhiladelphiaUSA

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