Pediatric and Adolescent Osteosarcoma

Volume 152 of the series Cancer Treatment and Research pp 309-318


Treatment of Osteosarcoma. The Scandinavian Sarcoma Group Experience

  • Øyvind S. BrulandAffiliated withThe Norwegian Radium Hospital, University of Oslo Email author 
  • , Henrik Bauer
  • , Thor Alvegaard
  • , Sigbjørn Smeland

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Results from four consecutive trials, conducted from 1982 by members of the Scandinavian Sarcoma Group, are reviewed. A total of 330 classical osteosarcoma patients were enrolled. In all trials chemotherapy was based on the three active drugs, methotrexate, doxorubicin and cisplatinum and for the latter trials also ifosfamide. Post-operative chemotherapy was stratified by histological response to up-front treatment.