Molecular Farming of Antibodies in Plants

  • Rainer Fischer
  • Stefan Schillberg
  • Richard M. Twyman


Biopharmaceuticals are produced predominantly in microbial or mammalian bioreactor systems. Over the last few years, however, it has become clear that plants have great potential for economical, large-scale biopharmaceutical production. Following the commercial release of several maize-derived technical proteins, the first plant-derived veterinary vaccine was approved in 2006. Plants offer the prospect of inexpensive production without sacrificing product quality or safety. The first therapeutic products for use in humans – mostly antibodies and vaccine candidates – are now at the clinical trials stage. In this chapter, we discuss the different plant-based production systems that have been used to synthesize recombinant antibodies and to evaluate the merits of plants compared with other platforms. Despite the currently unclear regulatory framework, the benefits of plant-derived systems are now bringing the prospect of inexpensive recombinant antibodies closer than ever before.


Recombinant Protein Hairy Root Tobacco Mosaic Virus Hairy Root Culture Recombinant Antibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Rainer Fischer
    • 1
  • Stefan Schillberg
    • 1
  • Richard M. Twyman
    • 2
  1. 1.Fraunhofer Institute for Molecular Biology and Applied Ecology (IME)52074 AachenGermany
  2. 2.Department of BiologyUniversity of York, Heslington, YorkQueryUK

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