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Design Of Next Generation Force Fields From AB Initio Computations: Beyond Point Charges Electrostatics

  • G.A. Cisneros
  • T.A. Darden
  • N. Gresh
  • J. Pilmé
  • P. Reinhardt
  • O. Parisel
  • J.-P. Piquemal
Part of the Challenges and Advances in Computational Chemistry and Physics book series (COCH, volume 7)

Abstract

We present an overview of the energy functions used in two Anisotropic Polarizable Molecular Mechanics (APMM) procedures namely SIBFA (Sum of Interactions Between Fragments Ab initio computed) and GEM (Gaussian Electrostatic Model). As SIBFA is a second generation APMM scheme based on distributed multipoles, GEM is the first third generation APMM as it uses distributed hermite densities obtained from density fitting. The two approaches are formulated and calibrated on the basis of quantum chemistry. They embody nonclassical effects such as electrostatic penetration, exchange-polarization, and charge transfer. We address here the technical issues of anisotropy, nonadditivity, transferability and computational speedup of methods. In addition, we review the several ab initio intermolecular energy decomposition techniques that can be used to refine polarisable force fields. As we summarize their differences and similarities, we present our own scheme based on Fragment Localized Kohn-Sham orbitals through a Singles- Configuration Interaction (CI) procedure. We also present a chemically intuitive method based on the Electron Localization Function (ELF) which allows to unravel the local electrostatic properties beyond atomic centers: i.e., on bonds, lone pairs and π system, an useful asset to understand bonding in molecules in order to build models

Keywords

Polarizable force fields Intermolecular interactions Energy decomposition Density fitting Electron localization function Topological analysis Localized orbitals Multipolar moments 

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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • G.A. Cisneros
    • 1
  • T.A. Darden
    • 1
  • N. Gresh
    • 2
  • J. Pilmé
    • 3
    • 4
    • 5
  • P. Reinhardt
    • 4
    • 5
  • O. Parisel
    • 4
    • 5
  • J.-P. Piquemal
    • 4
    • 5
  1. 1.Laboratory of Structural BiologyNational Institute of Environmental Health SciencesUSA
  2. 2.Laboratoire de Pharmacochimie Moléculaire et Cellulaire, U648 INSERM, UFR BiomédicaleUniversité René-DescartesFrance
  3. 3.Faculté de pharmacieUniversité de Lyon, Université Lyon 1F-69373 Lyon, Cedex 08France
  4. 4.Laboratoire de Chimie ThéoriqueUPMC Univ Paris 06, UMR 7616France
  5. 5.Laboratoire de Chimie ThéoriqueCNRS, UMR 7616France

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