From Protein Structure to Function with Bioinformatics

pp 251-272

Integrated Servers for Structure-Informed Function Prediction

  • Roman A. LaskowskiAffiliated withEuropean Bioinformatics Institute, Wellcome Trust Genome Campus Email author 

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No single method for predicting a protein's function from its three-dimensional structure is perfect; some methods work well in some cases, whereas other methods perform better in others. Consequently, it makes sense to apply a number of different predictive methods to a given protein structure and obtain either a consensus or the most likely prediction from them all. In this chapter we describe two web servers, ProKnow ( and ProFunc (, that use a cocktail of methods for predicting function from 3D structure.