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Biogenesis of c-type Cytochromes and Cytochrome Complexes

  • Carsten Sanders
  • Serdar Turkarslan
  • Ozlem Onder
  • Elaine R. Frawley
  • Robert G. Kranz
  • Hans Georg Koch
  • Fevzi DaldalEmail author
Part of the Advances in Photosynthesis and Respiration book series (AIPH, volume 28)

Summary

In most anoxygenic phototrophic bacteria, apocytochromes c are synthesized in the cytoplasm, translocated across the membrane and matured to holocytochromes c on the periplasmic side. The extracytoplasmic maturation process requires a complex biogenesis pathway (Ccm-system I) consisting of up to ten components to carry out specific steps. These include translocation and delivery of the heme, chaperoning and thio-oxidoreduction of the apocytochrome c as well as heme ligation steps. Because cytochromes are often part of multi-subunit protein complexes, matured holocytochromes may be assembled into active enzyme complexes. Examples include the ubihydroquinone:cytochrome c oxidoreductase (cytochrome bc 1 complex) or the aa 3- or cbb 3-type cytochrome c oxidases. Assemblies of these complexes are tightly coordinated and often require additional specific biogenesis components. In this chapter, we discuss the maturation process of c-type cytochromes and the assembly pathways of the aa 3- and cbb 3-type cytochrome c oxidases in anoxygenic phototrophic bacteria, with a specific focus on Rhodobacter species.

Keywords

Rhodobacter Sphaeroides Rhodobacter Capsulatus Anoxygenic Phototrophic Bacterium Heme Cofactor Binuclear Center 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

aa3-Cox

aa3-type Cyt c oxidase

apoCyt

immature Cyt c without its heme cofactor attached

B.

bacillus

BN-PAGE

blue-native polyacrylamide gel electrophoresis

cbb3-Cox

cbb3-type Cyt c oxidase

Ccm

cytochrome c maturation system I

Ccs

cytochrome maturation system II

Cyt

cytochrome

holo- and apo-CcmE

CcmE with and without its heme cofactor, respectively

holoCyt

mature Cyt c with its heme cofactor attached

pre-apoCyt

apoCyt c precursor with its signal sequence

Ps

photosynthetic

Rba.

Rhodobacter

Res

respiratory

TPR

Tetratricopeptide repeats

WWD

Tryptophan rich motif

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Copyright information

© Springer Science + Business Media B.V 2009

Authors and Affiliations

  • Carsten Sanders
    • 1
  • Serdar Turkarslan
    • 1
  • Ozlem Onder
    • 1
  • Elaine R. Frawley
    • 2
  • Robert G. Kranz
    • 2
  • Hans Georg Koch
    • 3
  • Fevzi Daldal
    • 1
    Email author
  1. 1.Department of Biology, Plant Science InstituteUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Department of BiologyWashington UniversitySaint LouisUSA
  3. 3.Institut für Biochemie und Molekularbiologie, Zentrum für Biochemie und Molekulare ZellforschungUniversity of FreiburgFreiburgGermany

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