Evolution from Cellular to Social Scales pp 83-90 | Cite as
Translation Attenuation Mechanism in Unfolded Protein Response
Conference paper
Abstract
Endoplasmic Reticulum is a cellular organelle where membrane and extracellular proteins are folded with the help of chaperons. Insulin is one example of such extracellular proteins. Unfolded Protein Response (UPR) is a cell response to an increased level of unfolded proteins in ER. In pancreatic β-cells failure in UPR leads to accumulation of unfolded insulin in Endoplasmic reticulum and eventual cell death. This is thought to be one of the causes of type two diabetes.
Keywords
UPR stress response translational attenuation unfolded protein responsePreview
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References
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