Translation Attenuation Mechanism in Unfolded Protein Response

  • Ala Trusina
  • Feroz Papa
  • Chao Tang
Conference paper
Part of the NATO Science for Peace and Security Series B: Physics and Biophysics book series (NAPSB)

Abstract

Endoplasmic Reticulum is a cellular organelle where membrane and extracellular proteins are folded with the help of chaperons. Insulin is one example of such extracellular proteins. Unfolded Protein Response (UPR) is a cell response to an increased level of unfolded proteins in ER. In pancreatic β-cells failure in UPR leads to accumulation of unfolded insulin in Endoplasmic reticulum and eventual cell death. This is thought to be one of the causes of type two diabetes.

Keywords

UPR stress response translational attenuation unfolded protein response 

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References

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    Axelsen, J. B. and Sneppen, K. (2004) Quantifying the benefits of translation regulation in the unfolded protein response, Phys. Biol. 1, 1–7.CrossRefGoogle Scholar
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Copyright information

© Springer Science + Business Media B.V 2008

Authors and Affiliations

  • Ala Trusina
    • 1
  • Feroz Papa
    • 1
  • Chao Tang
    • 1
  1. 1.QB3University of California at San FranciscoUSA

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