The modern rise in life expectancy is one of humanity’s crowning achievements. After more than 200,000 years of slow but steady increases in life expectancy for anatomically modern people like us (McNeill 1976), a new chapter in the book of human longevity began in the middle of the 19 th century when a quantum leap in duration of life began (Omran 1971). The external forces of mortality (e.g., infectious diseases, predation and accidents) that precluded survival beyond the first few years of life for most people were significantly relaxed as modern humans learned how to insulate themselves from the major hazards of the outside world. As a result, the biological consequences of aging are now a common occurrence for the first time in the history of our species. This longevity benefit, however, was accompanied by a trade-off involving a rise in such fatal diseases as cancer, heart disease, stroke and Alzheimer’s disease, as well as such chronic conditions as sensory impairments, arthritis and dementia.
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References
Allard M, Lebre V, Robine JM (1998) The longest life: The 122 extraordinary years of jeanne calment. W.H. Freeman and Co, New York
Armstrong GL, Conn LA, Pinner RW (1999) Trends in infectious disease mortality in the United States during the 20th century. JAMA 281(1):61–66
Austad S (1999) Why we age: What science is discovering about the body’s journey through life. John Wiley and Sons, New York
Bell FC, Miller ML (2002) Life tables for the United States social security area 1900–2100. Actuarial Study No. 116, Social Security Administration, Washington, DC
Bender R, Jockel KH, Trautner C, Spraul M, Berger M (1999) Effect of age on excess mortality in obesity. JAMA 281:1498–1504
Bongaarts J (2006) How long will we live? Popul Dev Rev 32(4):605–628
Bortz WM (1982) Disuse and aging. JAMA 248(10):1203–1208
Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath, Jr. CW (1999) Body-mass index and mortality in a prospective cohort of U.S. adults. N Engl J Med 341:1097–1105
Carnes BA (2004) Darwinian bodies in a Lamarckian world. Gerontologist 44:274–279
Carnes BA (2007) Senescence as viewed through the lens of comparative biology. Ann NY Acad Sci 114:14–22
Carnes BA, Olshansky SJ (1997) A biologically motivated partitioning of mortality. Exp Gerontol 32:615–631
Carnes BA, Olshansky SJ (2001) Heterogeneity and its biode-mographic implications for longevity and mortality. Exp Gerontol 36:419–430
Carnes BA, Olshansky SJ, Grahn D (2003) Biological evidence for limits to the duration of life. Biogerontology 4(1):31–45
Carnes BA, Olshansky SJ, Grahn D (2007) A realist view of aging, mortality, and future longevity. Popul Dev Rev 33(2):367–381
Carnes BA, Olshansky SJ, Grahn D (1996) Continuing the search for a law of mortality. Popul Dev Rev 22(2):231–264
Carnes BA, Holden LR, Olshansky SJ, Witten TM. Siegel JS. (2006) Mortality partitions and their relevance to research on senescence. Biogerontology 7:183–198
Carnes BA, Statts DO, Sonntag, WE (2008) Does senescence give risk to disease? Mech Aging Dev (in press)
Cutler RG, Semsei I (1989) Development, cancer and aging: Possible common mechanisms of action and regulation. J Gerontol: Biol Sci 44(6):25–34
de Grey A (2005) Foreseeable and more distant rejuvenation therapies. In: Rattan S (ed) Aging interventions and therapies, World Scientific, Singapore
de Grey A et al (2002) Time to talk SENS: critiquing the immutability of human aging. Ann NY Acad Sci 959:452–462
Diekema DJ, Beekmann SE, Chapin KC, Morel KA, Munson E, Doern GV (2003) Epidemiology and outcome of nosocomial and community-onset bloodstream infection. J Clin Microbiol 41(8):3655–3660
Ebbeling CB, Pawlak DB, Ludwig DS (2002) Childhood obesity: Public-health crisis, common sense cure. Lancet 360:473–482
Fiatarone MA, Evans WJ (1990) Exercise in the oldest old. Topics Geriatr Rehabil 5(2):63–77
Finch CE, Crimmins EM (2004) Inflammatory exposure and historical changes in human life-spans. Science 305:1736–1739
Flegal KM, Carroll MD, Ogden CL, Johnson CL (2002) Prevalence and trends in obesity among US adults, 1999–2000. JAMA 288:1723–1727
Fontaine KR, Redden DT, Wang C, Westfall AO, Allison DB (2003) Years of life lost due to obesity. JAMA 289:187–193
Freedman DS, Khan LK, Serdula MK, et al (2002) Trends and correlates of class 3 obesity in the United States from 1990 through 2000. JAMA 288:1758–1761
Fries JF (1980) Aging, natural death, and the compression of morbidity. N Engl J Med 303:130–135
Gruman GJ (1966) A history of ideas about the prolongation of life: The evolution of prolongevity hypotheses to 1800. Trans Am Phil Soc 56(9)
Gungor N, Thompson T, Sutton-Tyrrell K, Janosky J, Arslanian S (2005) Early signs of cardiovascular disease in youth with obesity and type 2 Diabetes. Diabetes Care 28:1219–1221
Hamilton WD (1966) The moulding of senescence by natural selection. J Theor Biol 12:12–45
Hayflick L (2000) The future of ageing. Nature 408:267–269
Holliday R (2007) Ageing: The paradox of life. Springer Publishing, New York
Jee SA, Sull JW, Park J, et al (2006) Body-mass index and mortality in Korean men and women. NEJM 355:779–787
Karon KM, Fleming PL, Steketee RW, De Cock KM (2001) HIV in the United States at the turn of the century: An epidemic in transition. Am J Public Health 91:1016–1017
Kirkwood TBL (1977) Evolution of aging. Nature 270:301–304
Kirkwood T (2003) Time of our lives: the science of human aging. Oxford University Press, Oxford
Kirkwood T, Finch C (2000) Change, development and ageing. Oxford University Press, Oxford
Kirkwood TBL, Holliday R (1979) The evolution of ageing and longevity. Proc R Soc Lond B Biol Sci 205:531–546
Kuriyama S (2006) Impact of overweight and obesity on medical care costs, all-cause mortality, and the risk of cancer in Japan. J Epidemiol 16(4):139–144
Kurzweil R, Grossman T (2004) Fantastic voyage: Live long enough to live forever. Rodale Press, Emmaus, PA
Kurzweil R (2005) The singularity is near: When humans transcend biology. Viking Press, New York
Manton KG, Stallard E, Tolley HD (1991) Limits to human life expectancy. Popul Dev Rev 17(4):603–637
Manton KG, Stallard E, Corder LS (1995) Changes in morbidity and chronic disability in the us elderly population: Evidence from the 1982, 1984, and 1989 national long term care surveys. J Gerontol B Psychol Sci Soc Sci 50(4):S194–S204
Manuel DG, Schultz SE (2004) Health-related quality of life and health-adjusted life expectancy of people with diabetes in Ontario, Canada, 1996–1997. Diabetes Care 27(2):407–414
McNeill WH. (1976) Plagues and peoples. Anchor, Garden City
McTigue K, Larson JC, Valoski A, et al (2006) Mortality and cardiac and vascular outcomes in extremely obese women. JAMA 296(1):79–86
Medawar PB (1952) An unsolved problem of biology. Lewis, London
Mokdad AH, Bowman BA, Ford ES, Vinicor F, Marks JS, Koplan JP (2001) The continuing epidemics of obesity and diabetes in the United States. JAMA 286:1195–2000
Morgan E (1994) The scars of evolution: What our bodies tell us about human origins. Oxford University Press, Oxford
Muennig P, Lubetkin E, Jia H, Franks P (2006) Gender and burden of disease attributable to obesity. AJPH 96(9):1662–1668
Must A, Jacques PF, Dallal GE, Bajema CJ, Dietz WH (1992) Long-term morbidity and mortality of overweight adolescents. A follow-up of the Harvard Growth Study of 1922 to 1935. N Engl J Med 327:1350–1355
Must A, Spadano J, Coakley EH, Field AE, Colditz G, Dietz WH (1999) The disease burden associated with overweight and obesity. JAMA 282:1523–1529
National Center for Health Statistics (1999) United States life tables eliminating certain causes of death, 1989–1991, vol 4, No. 1. DHHS (PHS) 99-1150-4
Nemetz PN, Roger VL, Ransom JE, Bailey KR, Leibson CL (2007) Recent trends in the prevalence of coronary disease: A population-based autopsy study of non-natural deaths. Arch Intern Med 261, 264–270
Oeppen J, Vaupel J (2002) Broken limits to life expectancy. Science 296(5570):1029–1031
Ogden CL, Flegal KM, Carroll MD, Johnson CL (2002) Prevalence and trends in overweight among US children and adolescents, 1999–2000. JAMA 288:1728–1732
Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM (2006) Prevalence of overweight and obesity in the United States, 1999–2004. JAMA 295:1549–1555
Olshansky SJ, Carnes BA (2001) The quest for immortality. Norton, New York
Olshansky SJ, Persky V (2007) The canary in the coal mine of coronary Artery Disease. Arch Intern Med 168(3):261
Olshansky SJ, Carnes BA, Cassel C (1990) In search of methuselah: Estimating the upper limits to human longevity. Science 250:634–640
Olshansky SJ, Carnes BA, Rogers RA, Smith L (1997) Infectious diseases: New and ancient threats to world health. Popul Bull 52(2):1–58
Olshansky SJ, Carnes BA, Grahn D (1998) Confronting the boundaries of human longevity. Am Sci 86(1):52–61
Olshansky SJ, Rogers RG, Carnes BA, Smith L (2000) Emerging infectious diseases: The fifth stage of the epidemiologic transition? World Health Stat Q 51(2,3,4):207–217
Olshansky SJ, Carnes BA, Butler R (2001) If humans were built to last. Sci Am 284(3):50–55
Olshansky SJ, Carnes BA, Désesquelles A (2001) Prospects for human longevity. Science 291(5508):1491–1492
Olshansky SJ, Hayflick L, Carnes BA, et al (2002) Position statement on human aging. Sci Am (June),http://www.sciam.com/agingstatement.cfm(Also published in the J Gerontol: Biol Sci 57A(8):B1–B6)
Olshansky SJ, Passaro D, Hershow R, Layden J, Carnes, BA, Brody J, Hayflick L, Butler, RN, Allison, DB, Ludwig, DS. (2005) A potential decline in life expectancy in the United States in the 21st century. New Engl J Med 352:1103–1110
Olshansky SJ, Perry D, Miller RA, Butler RN (2006) In pursuit of the longevity dividend. Scientist 20(3):28–36
Omran A. (1971) The epidemiologic transition: A theory of the epidemiology of population change. Milbank Mem Fund Q 49:509–538
Osmon S, Warren D, Seiler SM, Shannon W, Fraser VJ, Kollef MH (2003) The influence of infection on hospital mortality for patients requiring greater than 48 hours of intensive care. Chest 124(3):1021–1029
Schwimmer JB, Burwinkle TM, Varni JW (2003) Health-related quality of life of severely obese children and adolescents. JAMA 289:1813–1819
Shock N. (1957) Age changes in some physiologic processes. Geriatrics 12:40–48
Stearns SC (1992) The Evolution of life histories. Oxford University Press, New York
Thompson DW (1942) On growth and form. Dover Publications, New York
Tuljapurkar S, Li N, Boe C (2000) A universal pattern of mortality decline in G7 countries. Nature 405:789–792
United Nations (2003) The impact of AIDS. Population Division, ESA/P/WP.185, New York
Van Dam RM, Willett WC, Manson JE, Hu FB (2006) The relationship between overweight in adolescence and premature death in women. Ann Intern Med 145:91–97
Vaupel J (1997) Trajectories of mortality at advanced ages. In: Wachter K, Finch C, (ed) Between Zeus and the salmon. National Academy Press, Washington, DC, pp 17–37
Warner H et al (2005) Science fact and the SENS agenda: What can we reasonably expect from ageing research? EMBO Rep 6:1006–1008. Doi: 10.1038/sj.embor.7400555
Wearing SC, Hennig EM, Byrne NM, Steele JR, Hills AP (2006) Musculoskeletal disorders associated with obesity: A biome-chanical perspective. Obes Rev 7:239–250
Weismann A (1891) Essays upon heredity and kindred biological problems. Clarendon Press, Oxford
Williams GC (1957) Pleiotropy, natural selection and the evolution of senescence. Evolution 11:398–411
Wilmoth J (1997) In search of limits. In: Wachter K, Finch C, (ed) Between Zeus and the salmon, Washington, DC, National Academy Press, pp 38–64
Wilmoth J (1998) The future of human longevity: A demographer’s perspective. Science 280:395–397
Wilmoth J (2001) How long can we live? Science debate;http://www.sciencemag.org/cgi/eletters/291/5508/1491
Wilmoth JR, Deegan LJ, Lundstrom H, Horiuchi S (2000) Increase of maximum life-span in Sweden: 1861–1999. Science 289:2366–2368
World Health Organization (1999) Influenza pandemic plan. The role of WHO and guidelines for national and regional planning. WHO/CDS/CSR/EDC/99.1
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Olshansky, S.J., Carnes, B.A. (2009). The Future of Human Longevity. In: Uhlenberg, P. (eds) International Handbook of Population Aging. International Handbooks of Population, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8356-3_33
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