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Antioxidant Properties of Water-Soluble Fullerene Derivatives

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Book cover Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes

Part of the book series: Carbon Materials: Chemistry and Physics ((CMCP,volume 1))

Abstract

Due to their inherent electronic properties, fullerenes are considered as radical sponges being capable of effectively quenching reactive oxygen species (ROS). The most promising candidates for potential pharmaceutical applications are therefore water-soluble fullerene derivatives, since they provide reasonable biological availability. In light of these considerations, we give an overview over the most recent concepts for designing and synthesizing real water-soluble fullerene compounds. Several studies concerning the quenching activities against ROS-like Superoxide radical anion of some of these novel compounds are reviewed. We finally present first promising investigations about cytoprotective and neuroprotective activities of several carboxyfullerenes in zebrafish embroys as a mammalian model system. By comparing the activities for different addition patterns and other structural changes some first conclusions concerning a structure-function relationship can be drawn.

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Authors and Affiliations

  1. Department for Chemistry and Pharmacy & Interdisciplinary Center for Molecular Materials, Lehrstuhl für Organische Chemie II, Universität Erlangen-Nürnberg, Henkestrasse 42, D-91054, Erlangen, Germany

    Florian Beuerle & Andreas Hirsch

  2. Tego Biosciences, 201 South Lake Avenue, Pasadena, CA, 91101, USA

    Russell Lebovitz & Andreas Hirsch

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  1. Florian Beuerle
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  2. Russell Lebovitz
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  1. Lupi Chemical Research Institute, Via Casilina 1626/A, 00133, Rome, Italy

    Franco Cataldo (Director) (Director)

  2. Dipartimento di Scienze Farmaceutiche, University of Trieste, Piazzale Europe, I-34127, Trieste, Italy

    Tatiana Da Ros

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Beuerle, F., Lebovitz, R., Hirsch, A. (2008). Antioxidant Properties of Water-Soluble Fullerene Derivatives. In: Cataldo, F., Da Ros, T. (eds) Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes. Carbon Materials: Chemistry and Physics, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6845-4_3

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