Pathogenesis of Cryptococcus neoformans

  • Erin E. McClelland
  • Arturo Casadevall
  • Helene C. Eisenman

Cryptococcus neoformans (Cn) is a fungal pathogen, commonly found in urban environments (Tampieri, 2006) that primarily affects immunocompromised individuals through inhalation of spores. In healthy individuals Cn infection is usually cleared, or can remain in a latent form for prolonged periods of time. However, in individuals with impaired immune function, the infection may spread to the central nervous system (CNS), causing life-threatening meningitis (Casadevall & Perfect, 1998; Hull & Heitman, 2002). Thus, the disease is relatively common in AIDS patients. A recent study shows that the prevalence of cryptococcosis has declined with the increasing availability of highly active retroviral therapy (HAART) to treat HIV (Lortholary et al., 2006; Mirza et al., 2003). However, the disease continues to be a problem for those with limited access to HAART, especially in the developing world (Banerjee et al., 2001; Marques et al., 2000). Another group of individuals who are susceptible to cryptococcosis are organ transplant recipients receiving immunosuppressive therapy (Husain et al., 2001; Vilchez et al., 2002). However, cryptococcosis is not limited to immunocompromised persons, as shown by the recent outbreak in Vancouver among healthy individuals (Hoang et al., 2004).

Keywords

Nitrite Methionine Cyclosporine Catecholamine Microbe 

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References

  1. Abe, K., Kadota, J., Ishimatsu, Y., Iwashita, T., Tomono, K., Kawakami, K., & Kohno, S. (2000). Microbiol. Immunol., 44:849–855.PubMedGoogle Scholar
  2. Aguirre, K., Crowe, J., Haas, A., & Smith, J. (2004). Med. Mycol., 42:15–25.PubMedGoogle Scholar
  3. Aguirre, K. & Miller, S. (2002). Glia, 39:184–188.PubMedGoogle Scholar
  4. Akhter, S., McDade, H. C., Gorlach, J. M., Heinrich, G., Cox, G. M., & Perfect, J. R. (2003). Infect. Immun., 71:5794–5802.PubMedGoogle Scholar
  5. Almeida, G. M., Andrade, R. M., & Bento, C. A. (2001). J. Immunol., 167:5845–5851.PubMedGoogle Scholar
  6. Alspaugh, J. A., Cavallo, L. M., Perfect, J. R., & Heitman, J. (2000). Mol. Microbiol., 36:352–365.PubMedGoogle Scholar
  7. Alspaugh, J. A., Perfect, J. R., & Heitman, J. (1997). Genes Dev., 11:3206–3217.PubMedGoogle Scholar
  8. Alspaugh, J. A., Pukkila-Worley, R., Harashima, T., Cavallo, L. M., Funnell, D., Cox, G. M., Perfect, J. R., Kronstad, J. W., & Heitman, J. (2002). Eukaryot Cell, 1:75–84.PubMedGoogle Scholar
  9. Alvarez, M. & Casadevall, A. (2006). Curr. Biol., 16:2161–2165.PubMedGoogle Scholar
  10. Apidianakis, Y., Rahme, L. G., Heitman, J., Ausubel, F. M., Calderwood, S. B., & Mylonakis, E. (2004). Eukaryot Cell, 3:413–419.PubMedGoogle Scholar
  11. Aratani, Y., Kura, F., Watanabe, H., Akagawa, H., Takano, Y., Ishida-Okawara, A., Suzuki, K., Maeda, N., & Koyama, H. (2006). J. Med. Microbiol., 55:1291–1299.PubMedGoogle Scholar
  12. Bahn, Y. S., Hicks, J. K., Giles, S. S., Cox, G. M., & Heitman, J. (2004). Eukaryot Cell, 3:1476–1491.PubMedGoogle Scholar
  13. Bahn, Y. S., Kojima, K., Cox, G. M., & Heitman, J. (2005). Mol. Biol. Cell., 16:2285–2300.PubMedGoogle Scholar
  14. Bahn, Y. S., Kojima, K., Cox, G. M., & Heitman, J. (2006). Mol. Biol. Cell, 17:3122–3135.PubMedGoogle Scholar
  15. Banerjee, U., Datta, K., Majumdar, T., & Gupta, K. (2001). Med. Mycol., 39:51–67.PubMedGoogle Scholar
  16. Barbosa, F. M., Fonseca, F. L., Holandino, C., Alviano, C. S., Nimrichter, L., & Rodrigues, M. L. (2006). Microbes Infect., 8:493–502.PubMedGoogle Scholar
  17. Barluzzi, R., Brozzetti, A., Mariucci, G., Tantucci, M., Neglia, R. G., Bistoni, F., & Blasi, E. (2000). J. Neuroimmunol., 109:75–86.PubMedGoogle Scholar
  18. Bar-Peled, M., Griffith, C. L., & Doering, T. L. (2001). Proc. Natl. Acad. Sci. USA, 98:12003–12008.PubMedGoogle Scholar
  19. Bar-Peled, M., Griffith, C. L., Ory, J. J., & Doering, T. L. (2004). Biochem. J., 381:131–136.PubMedGoogle Scholar
  20. Blackstock, R., Buchanan, K. L., Adesina, A. M., & Murphy, J. W. (1999). Infect. Immun., 67:3601–3609.PubMedGoogle Scholar
  21. Blackstock, R., McCormack, J. M., & Hall, N. K. (1987). Infect. Immun., 55:233–239.PubMedGoogle Scholar
  22. Blackstock, R. & Murphy, J. W. (2004a). Infect. Immun., 72:5175–5180.PubMedGoogle Scholar
  23. Blackstock, R. & Murphy, J. W. (2004b). Am. J. Respir. Cell. Mol. Biol., 30:109–117.PubMedGoogle Scholar
  24. Bose, I., Reese, A. J., Ory, J. J., Janbon, G., & Doering, T. L. (2003). Eukaryot Cell, 2:655–663.PubMedGoogle Scholar
  25. Brandt, M. E., Hutwagner, L. C., Klug, L. A., Baughman, W. S., Rimland, D., Graviss, E. A., Hamill, R. J., Thomas, C., Pappas, P. G., Reingold, A. L., & Pinner, R. W. (1996). J. Clin. Microbiol., 34:912–917.PubMedGoogle Scholar
  26. Buchanan, K. L. & Doyle, H. A. (2000). Infect. Immun., 68:456–462.PubMedGoogle Scholar
  27. Bulmer, G. S. & Sans, M. D. (1968). J. Bacteriol., 95:5–8.PubMedGoogle Scholar
  28. Bulmer, G. S., Sans, M. D., & Gunn, C. M. (1967). J. Bacteriol., 94:1475–1479.PubMedGoogle Scholar
  29. Casadevall, A., Cleare, W., Feldmesser, M., Glatman-Freedman, A., Goldman, D. L., Kozel, T. R., Lendvai, N., Mukherjee, J., Pirofski, L. A., Rivera, J., Rosas, A. L., Scharff, M. D., Valadon, P., Westin, K., & Zhong, Z. (1998). Antimicrob. Agents Chemother., 42:1437–1446.PubMedGoogle Scholar
  30. Casadevall, A. & Perfect, J. R. (1998). Cryptococcus Neoformans, ASM Press, Washington DC.Google Scholar
  31. Casadevall, A. & Pirofski, L. (2005). Curr. Mol. Med., 5:421–433.PubMedGoogle Scholar
  32. Cenci, E., Bistoni, F., Mencacci, A., Perito, S., Magliani, W., Conti, S., Polonelli, L., & Vecchiarelli, A. (2004). Cell Microbiol., 6:953–961.PubMedGoogle Scholar
  33. Chaka, W., Verheul, A. F., Vaishnav, V. V., Cherniak, R., Scharringa, J., Verhoef, J., Snippe, H., & Hoepelman, I. M. (1997). Infect. Immun., 65:272–278.PubMedGoogle Scholar
  34. Chang, Y. C., Miller, G. F., & Kwon-Chung, K. J. (2003). Infect. Immun., 71:4953–4960.PubMedGoogle Scholar
  35. Chang, Y. C., Penoyer, L. A., & Kwon-Chung, K. J. (2001). Proc. Natl. Acad. Sci. USA, 98:3258–3263.PubMedGoogle Scholar
  36. Chang, Z. L., Netski, D., Thorkildson, P., & Kozel, T. R. (2006). Infect. Immun., 74:144–151.PubMedGoogle Scholar
  37. Charlier, C., Chretien, F., Baudrimont, M., Mordelet, E., Lortholary, O., & Dromer, F. (2005). Am. J. Pathol., 166:421–432.PubMedGoogle Scholar
  38. Chaturvedi, V., Wong, B., & Newman, S. L. (1996). J. Immunol., 156:3836–3840.PubMedGoogle Scholar
  39. Chen, S. C., Muller, M., Zhou, J. Z., Wright, L. C., & Sorrell, T. C. (1997). J. Infect. Dis., 175:414–420.PubMedGoogle Scholar
  40. Cherniak, R., Valafar, H., Morris, L. C., & Valafar, F. (1998). Clin. Diagn. Lab. Immunol., 5:146–159.PubMedGoogle Scholar
  41. Chiapello, L. S., Aoki, M. P., Rubinstein, H. R., & Masih, D. T. (2003). Med. Mycol., 41:347–353.PubMedGoogle Scholar
  42. Chiapello, L. S., Baronetti, J. L., Aoki, M. P., Gea, S., Rubinstein, H., & Masih, D. T. (2004). Immunology, 113:392–400.PubMedGoogle Scholar
  43. Coenjaerts, F. E., Hoepelman, A. I., Scharringa, J., Aarts, M., Ellerbroek, P. M., Bevaart, L., Van Strijp, J. A., & Janbon, G. (2006). FEMS Yeast Res., 6:652–661.PubMedGoogle Scholar
  44. Coenjaerts, F. E., Walenkamp, A. M., Mwinzi, P. N., Scharringa, J., Dekker, H. A., van Strijp, J. A., Cherniak, R., & Hoepelman, A. I. (2001). J. Immunol., 167:3988–3995.PubMedGoogle Scholar
  45. Cox, G. M., Mukherjee, J., Cole, G. T., Casadevall, A., & Perfect, J. R. (2000). Infect. Immun., 68:443–448.PubMedGoogle Scholar
  46. Cramer, K. L., Gerrald, Q. D., Nichols, C. B., Price, M. S., & Alspaugh, J. A. (2006). Eukaryot Cell, 5:1147–1156.PubMedGoogle Scholar
  47. Cruz, M. C., Del Poeta, M., Wang, P., Wenger, R., Zenke, G., Quesniaux, V. F., Movva, N. R., Perfect, J. R., Cardenas, M. E., & Heitman, J. (2000). Antimicrob. Agents Chemother., 44:143–149.PubMedGoogle Scholar
  48. Cruz, M. C., Fox, D. S., & Heitman, J. (2001). EMBO J., 20:1020–1032.PubMedGoogle Scholar
  49. Dadachova, E., Nakouzi, A., Bryan, R. A., & Casadevall, A. (2003). Proc. Natl. Acad. Sci. USA, 100:10942–10947.PubMedGoogle Scholar
  50. Davidson, R. C., Nichols, C. B., Cox, G. M., Perfect, J. R., & Heitman, J. (2003). Mol. Microbiol., 49:469–485.PubMedGoogle Scholar
  51. Delfino, D., Cianci, L., Lupis, E., Celeste, A., Petrelli, M. L., Curro, F., Cusumano, V., & Teti, G. (1997). Infect. Immun., 65:2454–2456.PubMedGoogle Scholar
  52. Denning, D. W., Armstrong, R. W., Lewis, B. H., & Stevens, D. A. (1991). Am. J. Med., 91:267–272.PubMedGoogle Scholar
  53. Doering, T. L., Nosanchuk, J. D., Roberts, W. K., & Casadevall, A. (1999). Med. Mycol., 37:175–181.PubMedGoogle Scholar
  54. Dong, Z. M. & Murphy, J. W. (1995a). Infect. Immun., 63:2632–2644.PubMedGoogle Scholar
  55. Dong, Z. M. & Murphy, J. W. (1995b). Infect. Immun., 63:770–778.PubMedGoogle Scholar
  56. Dong, Z. M. & Murphy, J. W. (1996). J. Clin. Invest., 97:689–698.PubMedGoogle Scholar
  57. Dong, Z. M. & Murphy, J. W. (1997). Infect. Immun., 65:557–563.PubMedGoogle Scholar
  58. D’Souza, C. A., Alspaugh, J. A., Yue, C., Harashima, T., Cox, G. M., Perfect, J. R., & Heitman, J. (2001). Mol. Cell. Biol., 21:3179–3191.PubMedGoogle Scholar
  59. D’Souza, C. A. & Heitman, J. (2001). FEMS Microbiol. Rev., 25:349–364.PubMedGoogle Scholar
  60. Edwards, L., Williams, A. E., Krieg, A. M., Rae, A. J., Snelgrove, R. J., & Hussell, T. (2005). Eur. J. Immunol., 35:273–281.PubMedGoogle Scholar
  61. Eisenman, H. C., Nosanchuk, J. D., Webber, J. B., Emerson, R. J., Camesano, T. A., & Casadevall, A. (2005). Biochemistry, 44:3683–3693.PubMedGoogle Scholar
  62. Ellerbroek, P. M., Hoepelman, A. I., Wolbers, F., Zwaginga, J. J., & Coenjaerts, F. E. (2002). Infect. Immun., 70:4762–4771.PubMedGoogle Scholar
  63. Ellerbroek, P. M., Ulfman, L. H., Hoepelman, A. I., & Coenjaerts, F. E. (2004). Cell Microbiol., 6:581–592.PubMedGoogle Scholar
  64. Erickson, T., Liu, L., Gueyikian, A., Zhu, X., Gibbons, J., & Williamson, P. R. (2001). Mol. Microbiol., 42:1121–1131.PubMedGoogle Scholar
  65. Feldmesser, M., Kress, Y., Novikoff, P., & Casadevall, A. (2000). Infect. Immun., 68:4225–4237.PubMedGoogle Scholar
  66. Feldmesser, M., Mednick, A., & Casadevall, A. (2002). Infect. Immun., 70:1571–80.PubMedGoogle Scholar
  67. Fleuridor, R., Lees, A., & Pirofski, L. (2001). J. Immunol., 166:1087–1096.PubMedGoogle Scholar
  68. Fox, D. S., Cruz, M. C., Sia, R. A., Ke, H., Cox, G. M., Cardenas, M. E., & Heitman, J. (2001). Mol. Microbiol., 39:835–849.PubMedGoogle Scholar
  69. Fox, D. S. & Heitman, J. (2005). Eukaryot Cell, 4:1526–1538.PubMedGoogle Scholar
  70. Fraser, J. A., Giles, S. S., Wenink, E. C., Geunes-Boyer, S. G., Wright, J. R., Diezmann, S., Allen, A., Stajich, J. E., Dietrich, F. S., Perfect, J. R., & Heitman, J. (2005). Nature, 437:1360–1364.PubMedGoogle Scholar
  71. Frases, S., Chaskes, S., Dadachova, E., & Casadevall, A. (2006a) Appl. Environ. Microbiol., 72:1542–1550.PubMedGoogle Scholar
  72. Frases, S., Salazar, A., & Casadevall, A. (2006b) Appl. Environ. Microbiol.Google Scholar
  73. Fries, B. C. & Casadevall, A. (1998). J. Infect. Dis., 178:1761–1766.PubMedGoogle Scholar
  74. Fries, B. C., Cook, E., Wang, X., & Casadevall, A. (2005). Antimicrob. Agents Chemother., 49:350–357.PubMedGoogle Scholar
  75. Fries, B. C., Goldman, D. L., Cherniak, R., Ju, R., & Casadevall, A. (1999). Infect. Immun., 67:6076–6083.PubMedGoogle Scholar
  76. Fries, B. C., Taborda, C. P., Serfass, E., & Casadevall, A. (2001). J. Clin. Invest., 108:1639–1648.PubMedGoogle Scholar
  77. Garcia-Hermoso, D., Dromer, F., & Janbon, G. (2004). Infect. Immun., 72:3359–3365.PubMedGoogle Scholar
  78. Garcia-Rivera, J., Chang, Y. C., Kwon-Chung, K. J., & Casadevall, A. (2004). Eukaryot Cell, 3:385–392.PubMedGoogle Scholar
  79. Garcia-Rivera, J., Eisenman, H. C., Nosanchuk, J. D., Aisen, P., Zaragoza, O., Moadel, T., Dadachova, E., & Casadevall, A. (2005a). Fungal Genet. Biol., 42:989–998.PubMedGoogle Scholar
  80. Garcia-Rivera, J., Tucker, S. C., Feldmesser, M., Williamson, P. R., & Casadevall, A. (2005b).Infect Immun., 73:3124–3127.PubMedGoogle Scholar
  81. Ghosn, E. E., Russo, M., & Almeida, S. R. (2006). J. Leukoc. Biol., 80:36–44.PubMedGoogle Scholar
  82. Giles, S. S., Batinic-Haberle, I., Perfect, J. R., & Cox, G. M. (2005). Eukaryot Cell, 4:46–54.PubMedGoogle Scholar
  83. Guerrero, A., Jain, N., Goldman, D. L., & Fries, B. C. (2006). Microbiology, 152:3–9.PubMedGoogle Scholar
  84. Gyetko, M. R., Sud, S., Chen, G. H., Fuller, J. A., Chensue, S. W., & Toews, G. B. (2002). J. Immunol., 168:801–809.PubMedGoogle Scholar
  85. He, W., Casadevall, A., Lee, S. C., & Goldman, D. L. (2003). Infect. Immun., 71:930–936.PubMedGoogle Scholar
  86. Heung, L. J., Luberto, C., Plowden, A., Hannun, Y. A., & Del Poeta, M. (2004). J. Biol. Chem., 279:21144–21153.PubMedGoogle Scholar
  87. Hicks, J. K., Bahn, Y. S., & Heitman, J. (2005). Eukaryot Cell, 4:1971–1981.PubMedGoogle Scholar
  88. Hill, H. Z. (1992). Bioessays, 14:49–56.PubMedGoogle Scholar
  89. Hirano, A., Zimmerman, H. M., & Levine, S. (1964a). Am. J. Pathol., 45:1–19.PubMedGoogle Scholar
  90. Hirano, A., Zimmerman, H. M., & Levine, S. (1964b). Am. J. Pathol., 45:195–207.PubMedGoogle Scholar
  91. Hoang, L. M., Maguire, J. A., Doyle, P., Fyfe, M., & Roscoe, D. L. (2004). J. Med. Microbiol., 53:935–940.PubMedGoogle Scholar
  92. Huang, C., Nong, S. H., Mansour, M. K., Specht, C. A., & Levitz, S. M. (2002). Infect. Immun., 70:5485–5493.PubMedGoogle Scholar
  93. Huffnagle, G. B. & McNeil, L. K. (1999). J. Neurovirol., 5:76–81.PubMedGoogle Scholar
  94. Hull, C. M., Boily, M. J., & Heitman, J. (2005). Eukaryot Cell, 4:526–535.PubMedGoogle Scholar
  95. Hull, C. M. & Heitman, J. (2002). Annu. Rev. Genet., 36:557–615.PubMedGoogle Scholar
  96. Husain, S., Wagener, M. M., & Singh, N. (2001). Emerg. Infect. Dis., 7:375–381.PubMedGoogle Scholar
  97. Idnurm, A., Bahn, Y. S., Nielsen, K., Lin, X., Fraser, J. A., & Heitman, J. (2005). Nat. Rev. Microbiol., 3:753–764.PubMedGoogle Scholar
  98. Jacobson, E. S. & Ikeda, R. (2005). Med. Mycol., 43:327–333.PubMedGoogle Scholar
  99. Jain, N., Li, L., McFadden, D. C., Banarjee, U., Wang, X., Cook, E., & Fries, B. C. (2006). Infect. Immun., 74:896–903.PubMedGoogle Scholar
  100. Janbon, G. (2004). FEMS Yeast Res., 4:765–771.PubMedGoogle Scholar
  101. Janbon, G., Himmelreich, U., Moyr&, F., Improvisi, L., & Dromer, F. (2001). Mol. Microbiol., 42:453–467.PubMedGoogle Scholar
  102. Kawakami, K. (2004). Jpn. J. Infect. Dis., 57:137–145.PubMedGoogle Scholar
  103. Kawakami, K., Kinjo, Y., Uezu, K., Yara, S., Miyagi, K., Koguchi, Y., Nakayama, T., Taniguchi, M., & Saito, A. (2001a) J. Immunol., 167:6525–6532.PubMedGoogle Scholar
  104. Kawakami, K., Kinjo, Y., Yara, S., Koguchi, Y., Uezu, K., Nakayama, T., Taniguchi, M., & Saito, A. (2001b) Infect. Immun., 69:213–220.PubMedGoogle Scholar
  105. Kawakami, K., Koguchi, Y., Qureshi, M. H., Kinjo, Y., Yara, S., Miyazato, A., Kurimoto, M., Takeda, K., Akira, S., & Saito, A. (2000). FEMS Microbiol. Lett., 186:121–126.PubMedGoogle Scholar
  106. Kawakami, K., Shibuya, K., Qureshi, M. H., Zhang, T., Koguchi, Y., Tohyama, M., Xie, Q., Naoe, S., & Saito, A. (1999). FEMS Immunol. Med. Microbiol., 25:391–402.PubMedGoogle Scholar
  107. Kelly, R. M., Chen, J., Yauch, L. E., & Levitz, S. M. (2005). Infect. Immun., 73:592–598.PubMedGoogle Scholar
  108. Kingsbury, J. M., Yang, Z., Ganous, T. M., Cox, G. M., & McCusker, J. H. (2004a). Microbiology, 150:1547–1558.PubMedGoogle Scholar
  109. Kingsbury, J. M., Yang, Z., Ganous, T. M., Cox, G. M., & McCusker, J. H. (2004b). Eukaryot Cell, 3:752–763.PubMedGoogle Scholar
  110. Kozel, T. R., Gulley, W. F., & Cazin, J., Jr. (1977). Infect. Immun., 18:701–707.PubMedGoogle Scholar
  111. Kozel, T. R. & Mastroianni, R. P. (1976). Infect. Immun., 14:62–67.PubMedGoogle Scholar
  112. Kraus, P. R., Fox, D. S., Cox, G. M., & Heitman, J. (2003). Mol. Microbiol., 48:1377–1387.PubMedGoogle Scholar
  113. Kraus, P. R. & Heitman, J. (2003). Biochem. Biophys. Res. Commun., 311:1151–1157.PubMedGoogle Scholar
  114. Kwon-Chung, K. J. & Rhodes, J. C. (1986). Infect. Immun., 51:218–223.PubMedGoogle Scholar
  115. Kwon-Chung, K. J. & Varma, A. (2006). FEMS Yeast Res., 6:574–587.PubMedGoogle Scholar
  116. Larsen, R. A., Pappas, P. G., Perfect, J., Aberg, J. A., Casadevall, A., Cloud, G. A., James, R., Filler, S. & Dismukes, W. E. (2005). Antimicrob. Agents Chemother., 49:952–958.PubMedGoogle Scholar
  117. Lendvai, N. & Casadevall, A. (1999). J. Infect. Dis., 180:791–801.PubMedGoogle Scholar
  118. Levitz, S. M., Nong, S., Mansour, M. K., Huang, C., & Specht, C. A. (2001). Proc. Natl. Acad. Sci. USA, 98:10422–10427.PubMedGoogle Scholar
  119. Levitz, S. M. & Specht, C. A. (2006). FEMS Yeast Res., 6:513–524.PubMedGoogle Scholar
  120. Lindell, D. M., Ballinger, M. N., McDonald, R. A., Toews, G. B., & Huffnagle, G. B. (2006). Infect. Immun., 74:4538–4548.PubMedGoogle Scholar
  121. Lindell, D. M., Moore, T. A., McDonald, R. A., Toews, G. B., & Huffnagle, G. B. (2005). J. Immunol., 174:7920–7928.PubMedGoogle Scholar
  122. Liu, L., Tewari, R. P., & Williamson, P. R. (1999). Infect. Immun., 67:6034–6039.PubMedGoogle Scholar
  123. Loftus, B. J., Fung, E., Roncaglia, P., Rowley, D., Amedeo, P., Bruno, D., Vamathevan, J., (2005). Science, 307:1321–1324.PubMedGoogle Scholar
  124. Lortholary, O., Poizat, G., Zeller, V., Neuville, S., Boibieux, A., Alvarez, M., Dellamonica, P., Botterel, F., Dromer, F., & Chene, G. (2006). Aids, 20:2183–2191.PubMedGoogle Scholar
  125. Lovchik, J. A., Wilder, J. A., Huffnagle, G. B., Riblet, R., Lyons, C. R., & Lipscomb, M. F. (1999). J. Immunol., 163:3907–3913.PubMedGoogle Scholar
  126. Luberto, C., Martinez-Marino, B., Taraskiewicz, D., Bolanos, B., Chitano, P., Toffaletti, D. L., Cox, G. M., Perfect, J. R., Hannun, Y. A., Balish, E., & Del Poeta, M. (2003). J. Clin. Invest., 112:1080–1094.PubMedGoogle Scholar
  127. Luberto, C., Toffaletti, D. L., Wills, E. A., Tucker, S. C., Casadevall, A., Perfect, J. R., Hannun, Y. A., & Del Poeta, M. (2001). Genes Dev., 15:201–212.PubMedGoogle Scholar
  128. Luo, Y., Cook, E., Fries, B. C., & Casadevall, A. (2006). Clin. Exp. Immunol., 145:380–387.PubMedGoogle Scholar
  129. Maitta, R. W., Datta, K., Lees, A., Belouski, S. S., & Pirofski, L. A. (2004). Infect. Immun., 72:196–208.PubMedGoogle Scholar
  130. Mambula, S. S., Simons, E. R., Hastey, R., Selsted, M. E., & Levitz, S. M. (2000). Infect. Immun., 68:6257–6264.PubMedGoogle Scholar
  131. Mansour, M. K., Latz, E., & Levitz, S. M. (2006). J. Immunol., 176:3053–3061.PubMedGoogle Scholar
  132. Mansour, M. K., Schlesinger, L. S., & Levitz, S. M. (2002). J. Immunol., 168:2872–2879.PubMedGoogle Scholar
  133. Mansour, M. K., Yauch, L. E., Rottman, J. B., & Levitz, S. M. (2004). Infect. Immun., 72:1746–1754.PubMedGoogle Scholar
  134. Mare, L., Iatta, R., Montagna, M. T., Luberto, C., & Del Poeta, M. (2005). J. Biol. Chem., 280:36055–36064.PubMedGoogle Scholar
  135. Marques, S. A., Robles, A. M., Tortorano, A. M., Tuculet, M. A., Negroni, R., & Mendes, R. P. (2000). Med. Mycol., 38(Suppl. 1):269–279.PubMedGoogle Scholar
  136. McClelland, E. E., Adler, F. R., Granger, D. L., & Potts, W. K. (2004b). Proc. R. Soc. Lond. B Biol. Sci., 271:1557–1564.Google Scholar
  137. McClelland, E. E., Granger, D. L., & Potts, W. K. (2003b). Infect. Immun., 71:4815–4817.PubMedGoogle Scholar
  138. McFadden, D. C., De Jesus, M., & Casadevall, A. (2006). J. Biol. Chem., 281:1868–1875.PubMedGoogle Scholar
  139. McGaha, T. & Murphy, J. W. (2000). Infect. Immun., 68:4624–4630.PubMedGoogle Scholar
  140. Mednick, A. J., Feldmesser, M., Rivera, J., & Casadevall, A. (2003). Eur. J. Immunol., 33:1744–1753.PubMedGoogle Scholar
  141. Mirza, S. A., Phelan, M., Rimland, D., Graviss, E., Hamill, R., Brandt, M. E., Gardner, T., Sattah, M., de Leon, G. P., Baughman, W., & Hajjeh, R. A. (2003). Clin. Infect. Dis., 36:789–794.PubMedGoogle Scholar
  142. Missall, T. A. & Lodge, J. K. (2005). Mol. Microbiol., 57:847–858.PubMedGoogle Scholar
  143. Missall, T. A., Moran, J. M., Corbett, J. A., & Lodge, J. K. (2005). Eukaryot Cell, 4:202–208.PubMedGoogle Scholar
  144. Missall, T. A., Pusateri, M. E., & Lodge, J. K. (2004). Mol. Microbiol., 51:1447–1458.PubMedGoogle Scholar
  145. Mody, C. H. & Syme, R. M. (1993). Infect. Immun., 61:464–469.PubMedGoogle Scholar
  146. Monari, C., Bistoni, F., Casadevall, A., Pericolini, E., Pietrella, D., Kozel, T. R., & Vecchiarelli, A. (2005a) J. Infect. Dis., 191:127–137.PubMedGoogle Scholar
  147. Monari, C., Kozel, T. R., Bistoni, F., & Vecchiarelli, A. (2002). Infect. Immun., 70:3363–3370.PubMedGoogle Scholar
  148. Monari, C., Kozel, T. R., Casadevall, A., Pietrella, D., Palazzetti, B., & Vecchiarelli, A. (1999). Immunology, 98:27–35.PubMedGoogle Scholar
  149. Monari, C., Pericolini, E., Bistoni, G., Casadevall, A., Kozel, T. R., & Vecchiarelli, A. (2005b). J. Immunol., 174:3461–3468.PubMedGoogle Scholar
  150. Monari, C., Pericolini, E., Bistoni, G., Cenci, E., Bistoni, F., & Vecchiarelli, A. (2005c). J. Infect. Dis., 191:307–311.PubMedGoogle Scholar
  151. Monari, C., Retini, C., Casadevall, A., Netski, D., Bistoni, F., Kozel, T. R., & Vecchiarelli, A. (2003). Eur. J. Immunol., 33:1041–1051.PubMedGoogle Scholar
  152. Moyrand, F., Chang, Y. C., Himmelreich, U., Kwon-Chung, K. J., & Janbon, G. (2004). Eukaryot Cell, 3:1513–1524.PubMedGoogle Scholar
  153. Moyrand, F. & Janbon, G. (2004). Eukaryot Cell, 3:1601–1608.PubMedGoogle Scholar
  154. Moyrand, F., Klaproth, B., Himmelreich, U., Dromer, F., & Janbon, G. (2002). Mol. Microbiol., 45:837–849.PubMedGoogle Scholar
  155. Mozaffarian, N., Casadevall, A., & Berman, J. W. (2000). J. Immunol., 165:1541–1547.PubMedGoogle Scholar
  156. Mukherjee, J., Cleare, W., & Casadevall, A. (1995). J. Immunol. Methods, 184:139–143.PubMedGoogle Scholar
  157. Murphy, J. W. & Cozad, G. C. (1972). Infect. Immun., 5:896–901.PubMedGoogle Scholar
  158. Mylonakis, E., Ausubel, F. M., Perfect, J. R., Heitman, J., & Calderwood, S. B. (2002). Proc. Natl. Acad. Sci. USA, 99:15675–15680.PubMedGoogle Scholar
  159. Mylonakis, E., Ausubel, F. M., Tang, R. J., & Calderwood, S. B. (2003). Expert Rev. Anti. Infect. Ther., 1:167–173.PubMedGoogle Scholar
  160. Mylonakis, E., Idnurm, A., Moreno, R., El Khoury, J., Rottman, J. B., Ausubel, F. M., Heitman, J., & Calderwood, S. B. (2004). Mol. Microbiol., 54:407–419.PubMedGoogle Scholar
  161. Mylonakis, E., Moreno, R., El Khoury, J. B., Idnurm, A., Heitman, J., Calderwood, S. B., Ausubel, F. M., & Diener, A. (2005). Infect. Immun., 73:3842–3850.PubMedGoogle Scholar
  162. Narasipura, S. D., Ault, J. G., Behr, M. J., Chaturvedi, V., & Chaturvedi, S. (2003). Mol. Microbiol., 47:1681–1694.PubMedGoogle Scholar
  163. Nichols, C. B., Fraser, J. A., & Heitman, J. (2004). Mol. Biol. Cell, 15:4476–4489.PubMedGoogle Scholar
  164. Nosanchuk, J. D. & Casadevall, A. (2003a). Microbiology, 149:1945–1951.PubMedGoogle Scholar
  165. Nosanchuk, J. D. & Casadevall, A. (2003b) Cell Microbiol., 5:203–223.PubMedGoogle Scholar
  166. Nosanchuk, J. D., Ovalle, R., & Casadevall, A. (2001). J. Infect. Dis., 183:1093–1099.PubMedGoogle Scholar
  167. Nosanchuk, J. D., Rosas, A. L., & Casadevall, A. (1998). J. Immunol., 160:6026–6031.PubMedGoogle Scholar
  168. Nosanchuk, J. D., Rosas, A. L., Lee, S. C., & Casadevall, A. (2000). Lancet, 355:2049–2050.PubMedGoogle Scholar
  169. Noverr, M. C., Cox, G. M., Perfect, J. R., & Huffnagle, G. B. (2003). Infect. Immun., 71:1538–1547.PubMedGoogle Scholar
  170. Noverr, M. C., Williamson, P. R., Fajardo, R. S., & Huffnagle, G. B. (2004). Infect. Immun., 72:1693–1699.PubMedGoogle Scholar
  171. Odom, A., Muir, S., Lim, E., Toffaletti, D. L., Perfect, J., & Heitman, J. (1997). EMBO J., 16:2576–2589.PubMedGoogle Scholar
  172. Olszewski, M. A., Noverr, M. C., Chen, G. H., Toews, G. B., Cox, G. M., Perfect, J. R., & Huffnagle, G. B. (2004). Am. J. Pathol., 164:1761–1771.PubMedGoogle Scholar
  173. Palmer, D. A., Thompson, J. K., Li, L., Prat, A., & Wang, P. (2006). J. Biol. Chem., 276:27026–27033.Google Scholar
  174. Panepinto, J., Liu, L., Ramos, J., Zhu, X., Valyi-Nagy, T., Eksi, S., Fu, J., Jaffe, H. A., Wickes, B., & Williamson, P. R. (2005). J. Clin. Invest., 115:632–641.PubMedGoogle Scholar
  175. Parra, C., Gonzalez, J. M., Castaneda, E., & Fiorentino, S. (2005). Biomedica, 25:110–119.PubMedGoogle Scholar
  176. Pascon, R. C., Ganous, T. M., Kingsbury, J. M., Cox, G. M., & McCusker, J. H. (2004). Microbiology, 150:3013–3023.PubMedGoogle Scholar
  177. Pericolini, E., Cenci, E., Monari, C., Perito, S., Mosci, P., Bistoni, G., & Vecchiarelli, A. (2006). Med. Mycol., 44:119–126.PubMedGoogle Scholar
  178. Pettoello-Mantovani, M., Casadevall, A., Kollmann, T. R., Rubinstein, A., & Goldstein, H. (1992). Lancet, 339:21–23.PubMedGoogle Scholar
  179. Pettoello-Mantovani, M., Casadevall, A., Smarnworawong, P., & Goldstein, H. (1994). AIDS Res. Hum. Retroviruses, 10:1079–1087.PubMedGoogle Scholar
  180. Pietrella, D., Cherniak, R., Strappini, C., Perito, S., Mosci, P., Bistoni, F., & Vecchiarelli, A. (2001a) Infect. Immun., 69:2808–2814.PubMedGoogle Scholar
  181. Pietrella, D., Lupo, P., Perito, S., Mosci, P., Bistoni, F., & Vecchiarelli, A. (2004). FEMS Immunol. Med. Microbiol., 40:63–70.PubMedGoogle Scholar
  182. Pietrella, D., Mazzolla, R., Lupo, P., Pitzurra, L., Gomez, M. J., Cherniak, R., & Vecchiarelli, A. (2002). Infect. Immun., 70:6621–6627.PubMedGoogle Scholar
  183. Pietrella, D., Perito, S., Bistoni, F., & Vecchiarelli, A. (2001b). Infect. Immun., 69:1508–1514.PubMedGoogle Scholar
  184. Pukkila-Worley, R. & Alspaugh, J. A. (2004). FEMS Yeast Res., 4:361–367.PubMedGoogle Scholar
  185. Pukkila-Worley, R., Gerrald, Q. D., Kraus, P. R., Boily, M. J., Davis, M. J., Giles, S. S., Cox, G. M., Heitman, J., & Alspaugh, J. A. (2005). Eukaryot Cell, 4:190–201.PubMedGoogle Scholar
  186. Reed, S. G. (1999). Microbes Infect., 1:1313–1325.PubMedGoogle Scholar
  187. Ren, P., Springer, D. J., Behr, M. J., Samsonoff, W. A., Chaturvedi, S., & Chaturvedi, V. (2006). Eukaryot Cell, 5:1065–1080.PubMedGoogle Scholar
  188. Retini, C., Casadevall, A., Pietrella, D., Monari, C., Palazzetti, B., & Vecchiarelli, A. (1999). J. Immunol., 162:1618–1623.PubMedGoogle Scholar
  189. Retini, C., Kozel, T. R., Pietrella, D., Monari, C., Bistoni, F., & Vecchiarelli, A. (2001). Infect. Immun., 69:6064–6073.PubMedGoogle Scholar
  190. Retini, C., Vecchiarelli, A., Monari, C., Bistoni, F., & Kozel, T. R. (1998). Infect. Immun., 66:664–669.PubMedGoogle Scholar
  191. Retini, C., Vecchiarelli, A., Monari, C., Tascini, C., Bistoni, F., & Kozel, T. R. (1996). Infect. Immun., 64:2897–2903.PubMedGoogle Scholar
  192. Rivera, J. & Casadevall, A. (2005). J. Immunol., 174:8017–8026.PubMedGoogle Scholar
  193. Rivera, J., Mukherjee, J., Weiss, L. M., & Casadevall, A. (2002). J. Immunol., 168:3419–3427.PubMedGoogle Scholar
  194. Rivera, J., Zaragoza, O., & Casadevall, A. (2005). Infect. Immun., 73:1141–1150.PubMedGoogle Scholar
  195. Rodrigues, M. L., Nimrichter, L., Oliveira, D. L., Frases, S., Miranda, K., Zaragoza, O., Alvarez, M., Nakouzi, A., Feldmesser, M., & Casadevall, A. (2006). Eukaryot Cell.Google Scholar
  196. Rosas, A. L., Nosanchuk, J. D., & Casadevall, A. (2001). Infect. Immun., 69:3410–3412.PubMedGoogle Scholar
  197. Rosas, A. L., Nosanchuk, J. D., Feldmesser, M., Cox, G. M., McDade, H. C., & Casadevall, A. (2000). Infect. Immun., 68:2845–2853.PubMedGoogle Scholar
  198. Santangelo, R., Zoellner, H., Sorrell, T., Wilson, C., Donald, C., Djordjevic, J., Shounan, Y., & Wright, L. (2004). Infect. Immun., 72:2229–2239.PubMedGoogle Scholar
  199. Shea, J. M. & Del Poeta, M. (2006). Curr. Opin. Microbiol., 9:352–358.PubMedGoogle Scholar
  200. Shea, J. M., Kechichian, T. B., Luberto, C., & Del Poeta, M. (2006). Infect. Immun., 74:5977–5988.PubMedGoogle Scholar
  201. Shen, W. C., Davidson, R. C., Cox, G. M., & Heitman, J. (2002). Eukaryot Cell, 1:366–377.PubMedGoogle Scholar
  202. Sommer, U., Liu, H., & Doering, T. L. (2003). J. Biol. Chem., 278:47724–47730.PubMedGoogle Scholar
  203. Steenbergen, J. N., Nosanchuk, J. D., Malliaris, S. D., & Casadevall, A. (2003). Infect. Immun., 71:4862–4872.PubMedGoogle Scholar
  204. Steenbergen, J. N., Shuman, H. A., & Casadevall, A. (2001). Proc. Natl. Acad. Sci. USA, 98:15245–15250.PubMedGoogle Scholar
  205. Syme, R. M., Bruno, T. F., Kozel, T. R., & Mody, C. H. (1999). Infect. Immun., 67:4620–4627.PubMedGoogle Scholar
  206. Syme, R. M., Spurrell, J. C., Amankwah, E. K., Green, F. H., & Mody, C. H. (2002). Infect. Immun., 70:5972–5981.PubMedGoogle Scholar
  207. Syme, R. M., Wood, C. J., Wong, H., & Mody, C. H. (1997). Immunology, 92:194–200.PubMedGoogle Scholar
  208. Taborda, C. P., Rivera, J., Zaragoza, O., & Casadevall, A. (2003). J. Immunol., 170:3621–3630.PubMedGoogle Scholar
  209. Tampieri, M. P. (2006). Parassitologia, 48:121–124.PubMedGoogle Scholar
  210. Tang, R. J., Breger, J., Idnurm, A., Gerik, K. J., Lodge, J. K., Heitman, J., Calderwood, S. B., & Mylonakis, E. (2005). Infect. Immun., 73:8219–8225.PubMedGoogle Scholar
  211. Uezu, K., Kawakami, K., Miyagi, K., Kinjo, Y., Kinjo, T., Ishikawa, H., & Saito, A. (2004). J. Immunol., 172:7629–7634.PubMedGoogle Scholar
  212. Uicker, W. C., Doyle, H. A., McCracken, J. P., Langlois, M., & Buchanan, K. L. (2005). Med. Mycol., 43:27–38.PubMedGoogle Scholar
  213. Vaishnav, V. V., Bacon, B. E., O’Neill, M., & Cherniak, R. (1998). Carbohydr. Res., 306:315–330.PubMedGoogle Scholar
  214. Vecchiarelli, A. (2000). Med. Mycol., 38:407–417.PubMedGoogle Scholar
  215. Vecchiarelli, A., Pietrella, D., Lupo, P., Bistoni, F., McFadden, D. C., & Casadevall, A. (2003). J. Leukoc. Biol., 74:370–378.PubMedGoogle Scholar
  216. Vecchiarelli, A., Retini, C., Monari, C., Tascini, C., Bistoni, F., & Kozel, T. R. (1996). Infect. Immun., 64:2846–2849.PubMedGoogle Scholar
  217. Vecchiarelli, A., Retini, C., Pietrella, D., Monari, C., Tascini, C., Beccari, T., & Kozel, T. R. (1995). Infect. Immun., 63:2919–2923.PubMedGoogle Scholar
  218. Vilchez, R. A., Fung, J., & Kusne, S. (2002). Am. J. Transplant, 2:575–580.PubMedGoogle Scholar
  219. Walton, F. J., Idnurm, A., & Heitman, J. (2005). Mol. Microbiol., 57:1381–1396.PubMedGoogle Scholar
  220. Wang, P., Cardenas, M. E., Cox, G. M., Perfect, J. R., & Heitman, J. (2001). EMBO Rep., 2:511–518.PubMedGoogle Scholar
  221. Wang, P., Nichols, C. B., Lengeler, K. B., Cardenas, M. E., Cox, G. M., Perfect, J. R., & Heitman, J. (2002). Eukaryot Cell, 1:257–272.PubMedGoogle Scholar
  222. Wang, Y., Aisen, P., & Casadevall, A. (1996). Infect. Immun., 64:2420–2424.PubMedGoogle Scholar
  223. Waterman, S. R., Hacham, M., Panepinto, J., Hu, G., Shin, S., & Williamson, P. R. (2006). Infect. Immun.Google Scholar
  224. Williamson, P. R. (1994). J. Bacteriol., 176:656–664.PubMedGoogle Scholar
  225. Wills, E. A., Roberts, I. S., Del Poeta, M., Rivera, J., Casadevall, A., Cox, G. M., & Perfect, J. R. (2001). Mol. Microbiol., 40, 610–620.PubMedGoogle Scholar
  226. Wormley, F. L., Jr., Heinrich, G., Miller, J. L., Perfect, J. R., & Cox, G. M. (2005). Infect. Immun., 73:5022–5030.PubMedGoogle Scholar
  227. Wozniak, K. L., Vyas, J. M., & Levitz, S. M. (2006). Infect. Immun., 74:3817–3824.PubMedGoogle Scholar
  228. Wright, L. C., Payne, J., Santangelo, R. T., Simpanya, M. F., Chen, S. C., Widmer, F., & Sorrell, T. C. (2004). Biochem. J., 384:377–384.PubMedGoogle Scholar
  229. Xue, C., Bahn, Y. S., Cox, G. M., & Heitman, J. (2006). Mol. Biol. Cell, 17:667–679.PubMedGoogle Scholar
  230. Yang, Z., Pascon, R. C., Alspaugh, A., Cox, G. M., & McCusker, J. H. (2002). Microbiology, 148:2617–2625.PubMedGoogle Scholar
  231. Yauch, L. E., Lam, J. S., & Levitz, S. M. (2006). PLoS Pathog., 2.Google Scholar
  232. Yoneda, A. & Doering, T. L. (2006). Mol. Biol. Cell.Google Scholar
  233. Yuan, R., Casadevall, A., Spira, G., & Scharff, M. D. (1995). J. Immunol., 154:1810–1816.PubMedGoogle Scholar
  234. Yuan, R. R., Casadevall, A., Oh, J., & Scharff, M. D. (1997). Proc. Natl. Acad. Sci. USA, 94:2483–2488.PubMedGoogle Scholar
  235. Yuan, R. R., Spira, G., Oh, J., Paizi, M., Casadevall, A., & Scharff, M. D. (1998). Infect. Immun., 66:1057–1062.PubMedGoogle Scholar
  236. Zaragoza, O., Telzak, A., Bryan, R. A., Dadachova, E., & Casadevall, A. (2006). Mol. Microbiol., 59:67–83.PubMedGoogle Scholar
  237. Zhang, H., Zhong, Z., & Pirofski, L. A. (1997). Infect. Immun., 65:1158–1164.PubMedGoogle Scholar
  238. Zhang, S., Hacham, M., Panepinto, J., Hu, G., Shin, S., Zhu, X., & Williamson, P. R. (2006). Mol. Microbiol., 62:1090–1101.PubMedGoogle Scholar
  239. Zhou, Q., Gault, R. A., Kozel, T. R., & Murphy, W. J. (2006). Infect. Immun., 74:2161–2168.PubMedGoogle Scholar
  240. Zhu, X. & Williamson, P. R. (2003). Mol. Microbiol., 50:1271–1281.PubMedGoogle Scholar

Copyright information

© Springer 2007

Authors and Affiliations

  • Erin E. McClelland
    • 1
  • Arturo Casadevall
    • 1
  • Helene C. Eisenman
    • 1
  1. 1.Albert Einstein College of MedicineBronxUSA

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