Multiple Stressors: A Challenge for the Future pp 271-286 | Cite as
Genetic Effects of Combined Action of Some Chemicals and Ionizing Radiation in Animals and Human Cells
Environmental contamination by radionuclides and different chemical substances results in exposure of human and other beings to a complex of physical and chemical factors. Results of combined influence of diverse agents can be unpredictable, because observed effects can differ from the sum of effects of each one taken separately.We studied cytogenetic effects of sodium nitrite and nitrate in drosophila and mice. It was found that these substances didn’t possess mutagenic activity and sensibilized significantly (2–4 times) genetic effect of ionizing radiation. Genetic effects of herbicide zenkor were found to be completely different. Zenkor has mutagenic activity and irradiation of zenkor-treated mice results in decreasing aberration levels.
Keywords
Genetic Effect Reciprocal Translocation Sodium Nitrite Pigment Melanin Acute IrradiationPreview
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References
- Azatyan, R. A., V. A. Avakyan, and G. I. Mirzoyan, Cytogenetic effect of pesticides zenkor, bazagrane and difenamide, Cytol. Genet. 18(6), 460–462 (1984).Google Scholar
- Baraboi, V. A. Plants phenols and human health (Nauka, Moscow, 1984).Google Scholar
- Berdishev, G. D. About protective action of melanin in irradiated mouse, Radiobiologia, 4, 644–645 (1964).Google Scholar
- Evans, E. P., C. E. Ford, A. G. Searle, and B. J. West, Studies on the induction of translocations in mouse spermatogonia. III. Effect of X-irradiation, Mutat. Res., 9(5), 501–506 (1970).Google Scholar
- Grossi, G. F., M. Durante, G. Gialanella, M. Pugliese, and I. Mosse, Effects of melanin on high- and low- linear energy of human epithelial cells, Radiat. Environ. Biophys. 37, 63–67 (1998).CrossRefGoogle Scholar
- Hill, H. Z. The function of melanin or six blind people examine an elephant, Bioassays 14, 49–56 (1992).CrossRefGoogle Scholar
- Hollaender and G. Steplton, Ionizing radiation and cell metabolism, Physiol. Rev. 33, 77–81 (1953).Google Scholar
- Hopwood, L. E., H. M. Swartz, and S. Pajak, Effect of melanin on radiation response of CHO cells, Int. J. Radiat. Biol. 47, 531–537 (1985).CrossRefGoogle Scholar
- Khalikov, P. Kh. Chromosomal mutation level in bone marrow cells of wild mice from the area of intensive pesticide use. Cytol. Genet. 24(5), 10–13 (1990).Google Scholar
- Krivolutzky, L. A., A. B. Smirnov, and M. A. Snetkov, Influence of soil radiocontamination with 90Str on some organisms variability, General Biol., 33, 581–591 (1972).Google Scholar
- Malama, A. and P. A. Bulanov, Melanin influence on Erlich tumour, Rep. Acad Sci. BSSR, 9, 627–629 (1965).Google Scholar
- Mosse, I. B. Radiation and Heredity. Genetic aspect of antiradiation protection (University Press, Minsk, 1990).Google Scholar
- Mosse, I. B. and E. N. Makeeva, Modifying action of some chemicals on radiation genetic effects, 10th Int. Congress of Radiation Research, Vurzburg, Germany, Congr. Proc. 1, 1–38 (1996).Google Scholar
- Mosse, I. B. and I. P. Lyach, Influence of melanin on mutation load in Drosophila population after long-term irradiation, Radiat. Res. 139, 356–358 (1994).CrossRefGoogle Scholar
- Mosse, I. B., S. I. Plotnikova, and I. P. Lyakh, Genetic changes induced by ionizing radiation in complex with sodium nitrite and nitrate in animals (BELNIITI, Minsk, 1990).Google Scholar
- Mosse, I. B., B. V. Dubovic, S. I. Plotnikova, L. N. Kostrova, and S. T. Subbot, Melanin decreases remote consequences of long-term irradiation, Int Congr. on Radiation Protection, Austria, Congr. Proc., part 4:Vienna, pp. 168–170 (1996).Google Scholar
- Moorhead, P. S., P. C. Navell, W. J. Meliman, D. H. Battips, and D. A. Hungerford, Chromosome preparation of leukocytes cultured from human peripheral blood, Exp. Cell Res. 20, 613–616 (1960).CrossRefGoogle Scholar
- Mosse, I. B., P. Marozik, C. Seymour, and C. Mothersill, Melanin influence on bystander effect in human keratinocytes, Mutat. Res. 597(1–2), 133–137 (2006).Google Scholar
- Mosse, I. B., L. N. Kostrova, S. T. Subbot, I. Maksimenya, and V. P. Molophei, Melanin decreases clastogenic effects of ionizing radiation in human and mouse somatic cells and modifies the radioadaptive response, Radiat. Environ. Biophys. 39(1) 47–52 (2000).Google Scholar
- Preston, R. I., B. J. Dean, Sh. Galloway, Mammalian in vivo cytogenetic assays analysis of chromosome aberration in bone marrow cells, Mutat. Res. 189, 157–165 (1987).CrossRefGoogle Scholar
- Shilds, L. M. and L. W. Durell, Preliminary observations on radiosensitivity of Algae and fungi from soils of the Nevada test site, Ecology, 42, 440–441 (1961).CrossRefGoogle Scholar
- Stroev, V. S. Cytogenetic activity of herbicides simazine and gidrasine, Genetika, 4(12), 130–134 (1968).Google Scholar
- Stroev, V. S. Cytogenetic activity of herbicides atrazine and parakvate, Genetika, 6(3), 31–37 (1970).Google Scholar
- Sultanov, S. and A. K. Ergashev, Comparative study of mutagenic effects of herbicides cotorane and toluene in the cells of some plants, Genetika, 27(11), 2057–2059 (1981).Google Scholar
- Wallace, B. and J. C. King, A genetic analysis of the adaptive values of populations, Proc. Natl. Acad. Sci. USA, 38, 706–713 (1958).CrossRefGoogle Scholar