Ecotoxicological effects of endocrine disrupting compounds on fish reproduction

  • Nancy Denslow
  • Maria Sepúlveda

Public concern about the potential effects of endocrine disrupting chemicals (EDCs) on wildlife and human health has heightened experimental paradigms to assess the mechanistic effects of exposure to these compounds. The worry stems from the known effects caused in humans by exposure of pregnant mothers to the synthetic estrogen, diethylstilbestrol (DES) to help them avoid miscarriage (Milhan, 1992). The effects were observed 20 years after the initial exposure of the mothers and resulted in a higher than normal chance of inducing rare endocrine-related cancers as well as other reproductive abnormalities in their progeny.


Rainbow Trout Early Life Stage Largemouth Bass Danio Rerio Fathead Minnow 
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Copyright information

© Springer 2007

Authors and Affiliations

  • Nancy Denslow
    • 1
  • Maria Sepúlveda
    • 2
  1. 1.Department of Physiological Sciences and Center for Environmental and Human ToxicologyUniversity of FloridaGainesvilleUSA
  2. 2.Department of Forestry and Natural Resources and School of Civil EngineeringPurdue UniversityWest LafayetteUSA

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