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Annexinopathies

  • M.J. HAYES
  • R.E. LONGBOTTOM
  • M.A. EVANS
  • S.E. MOSS
Chapter
Part of the Subcellular Biochemistry book series (SCBI, volume 45)

Abstract

Annexins comprise a conserved family of proteins characterised by their ability to bind and order charged phospholipids in membranes, often in response to elevated intracellular calcium. The family members (there are at least 12 in humans) have become specialized over evolutionary time and are involved in a diverse range of cellular functions both inside the cell and extracellularly Although a mutation in an annexin has never been categorically proven to be the cause of a disease state, they have been implicated in pathologies as diverse as autoimmunity, infection, heart disease, diabetes and cancer. ‘Annexinopathies’ were first described by Jacob H. Rand to describe the pathological sequelae in two disease states, the over-expression of annexin 2 in a patients with a haemorrhagic form of acute promyelocytic leukaemia, and the under-expression of annexin 5 on placental trophoblasts in the antiphospholipid syndrome. In this chapter we will outline some of the more recent observations in regard to these conditions, and describe the involvement of annexins in some other major causes of human morbidity

Keywords

Annexin phospholipid fibrinolysis endosome cancer glucocorticoid inflammation 

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Copyright information

© Springer 2007

Authors and Affiliations

  • M.J. HAYES
    • 1
  • R.E. LONGBOTTOM
    • 1
  • M.A. EVANS
    • 1
  • S.E. MOSS
    • 1
  1. 1.Div. of Cell BiologyUniversity College London Institute of OphthalmologyUK

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