The Peroxiredoxin Repair Proteins

  • Thomas J. Jönsson
  • W. Todd Lowther
Part of the Subcellular Biochemistry book series (SCBI, volume 44)

Abstract

Sulfiredoxin and sestrin are cysteine sulfinic acid reductases that selectively reduce or repair the hyperoxidized forms of typical 2-Cys peroxiredoxins within eukaryotes. As such these enzymes play key roles in the modulation of peroxide-mediated cell signaling and cellular defense mechanisms. The unique structure of sulfiredoxin facilitates access to the peroxiredoxin active site and novel sulfur chemistry

Keywords

Cysteine sulfinic acid Retroreduction Sulfiredoxin Sestrin 

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Copyright information

© Springer 2007

Authors and Affiliations

  • Thomas J. Jönsson
    • 1
  • W. Todd Lowther
    • 1
  1. 1.Center for Structural Biology, Department of BiochemistryWake Forest University School of MedicineWinston-SalemUSA

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