Molecular farming of antibodies in plants

  • Richard M. Twyman
  • Stefan Schillberg
  • Rainer Fischer


Antibodies are multi-subunit glycoproteins, produced by the vertebrate immune system. They recognize and bind to their target antigens with great affinity and specificity, which allows them to be used for many applications, including the diagnosis, prevention and treatment of human and animal disease (Anderson and Krummen 2003; Chad and Chamow 2001; Fischer and Emans 2000). It is estimated that approximately 1000 therapeutic recombinant antibodies are under development, up to one quarter of which may already be undergoing clinical trials. A large proportion of these antibodies recognize cancer antigens but others have been developed for the diagnosis and treatment of infectious diseases, acquired disorders and even transplant rejection (Gavilondo and Larrick 2000). As well as biomedical applications, antibodies can also be exploited to prevent diseases in plants (Schillberg et al. 2001), to detect and remove environmental contaminants, and for various industrial processes such as affinity purification and molecular targeting (Stoger et al. 2005b).


Transgenic Plant Total Soluble Protein Recombinant Antibody Glycan Structure Plastid Transformation 
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Copyright information

© Springer 2007

Authors and Affiliations

  • Richard M. Twyman
    • 1
  • Stefan Schillberg
    • 2
  • Rainer Fischer
    • 2
  1. 1.Department of BiologyUniversity of YorkYorkUnited Kingdom
  2. 2.Fraunhofer Institute for Molecular Biology and Applied Ecology (IME)AachenGermany

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