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Redox Regulation by Reduced Waters as Active Hydrogen Donors and Intracellular ROS Scavengers for Prevention of type 2 Diabetes

  • S. Shirahata
  • Y. Li
  • T. Hamasaki
  • Z. Gadek
  • K. Teruya
  • S. Kabayama
  • K. Otsubo
  • S. Morisawa
  • Y. Ishii
  • Y. Katakura
Conference paper

Abstract

*The analysis using the DBNBS reduction method and the DCFH-DA intracellular reactive oxygen species (ROS) determination method revealed that ERW and diseases-improvable natural waters such as Nordenau water in Germany and Hita water in Japan were all reduced waters (RWs) which could function as active hydrogen donors and intracellular ROS scavengers. RWs suppressed the activity of protein tyrosine phosphatase (PTP), which inactivates insulin receptor, suggesting their anti-type 2 diabetes effects via redox regulation. The clinical test of 356 diabetes patients drinking Nordenau water in Germany resulted in the improvement of the relevant tests parameters after 6 days, suggesting the correlation of these changes with the fluctuation of ROS levels in their blood.

Keywords

Reactive Oxygen Species Reactive Oxygen Species Level Protein Tyrosine Phosphatase Redox Regulation Nitrophenyl Phosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2007

Authors and Affiliations

  • S. Shirahata
    • 1
  • Y. Li
    • 1
  • T. Hamasaki
    • 1
  • Z. Gadek
    • 2
  • K. Teruya
    • 1
  • S. Kabayama
    • 3
  • K. Otsubo
    • 3
  • S. Morisawa
    • 3
  • Y. Ishii
    • 4
  • Y. Katakura
    • 4
  1. 1.Department of Genetic Resources Technology, Faculty of AgricultureKyushu UniversityFukuokaJapan
  2. 2.Centre for Holistic Medicine and NaturopathyNordenauGermany
  3. 3.Nihon Trim Co.LtdOsakaJapan
  4. 4.Hita Tenryosui Co. LtdHitaJapan

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