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Growth of Mammalian and Lepidopteran Cells on BioNOC® II Disks, a Novel Macroporous Microcarrier

  • Jean-Christophe Drugmand
  • Jean-François Michiels J.-F.
  • Spiros Agathos
  • Yves-Jaques Schneider
Conference paper

Abstract

The use of BioNOC II microcarriers in a fixed bed bioreactor setup allows to produce high protein levels in a CHO-320 cell line expressing constitutively interferon-γ and also with insect cells used with a baculovirus transient expression vector.

Keywords

Insect Cell Ammonia Production High Protein Level Insect Cell Culture Baculovirus Expression Vector System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Burteau, C. C., F. R. Verhoeye et al. (2003). “Fortification of a protein-free cell culture medium with plant peptones improves cultivation and productivity of an interferon-producing CHO cell line.” In Vitro Cellular and Developmental Biology 39: 291–296.CrossRefGoogle Scholar
  2. Ikonomou, L., G. Bastin et al. (2001). “Design of an efficient medium for insect cell culture and recombinant protein production.” In Vitro Cellular and Developmental Biology-Animal 37: 549–559.CrossRefGoogle Scholar

Copyright information

© Springer 2007

Authors and Affiliations

  • Jean-Christophe Drugmand
    • 2
  • Jean-François Michiels J.-F.
    • 1
  • Spiros Agathos
    • 2
  • Yves-Jaques Schneider
    • 1
  1. 1.Unit of BioengineeringUniversité Catholique de Louvain, Institut des Sciences de la VieBelgium
  2. 2.Unit of Cellular BiochemistryUniversité Catholique de Louvain, Institut des Sciences de la VieBelgium

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