Apoptosis and Replicative Senescence in Cancer
In normal tissues, cell proliferation is limited by terminal differentiation and counterbalanced by cell loss, often via apoptosis. Cell damage also elicits apoptosis or necrosis. Moroever, apoptosis can be induced in response to inappropriate proliferation or by cytotoxic immune cells.
KeywordsTelomere Length Death Receptor Mitochondrial Permeability Transition Intrinsic Pathway Extrinsic Pathway
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