Abstract
Although evidence that L-glutamic acid is a neurotransmitter in the vertebrate central nervous system (CNS) is incomplete it is generally accepted that this amino acid is the mediator of transmission at arthropod nerve-muscle junctions (Usherwood, 1978, 1980a, b, 1981; Nistri & Constanti, 1979). Given the complexities of vertebrate central nervous organization compared with the arthropod nerve-muscle system it is perhaps unwise to compare their pharmacological properties without major qualifications. Recent electrophysiological evidence suggests the presence of three types of amino acid receptor for glutamate in the CNS; a quisqualate-responsive site: a N-methyl-D-aspartate-responsive site and a kainate-responsive site (Watkins & Evans, 1981). This conclusion is generally supported by the results of ligand binding studies (e.g. Foster & Roberts, 1978). The quisqualate-responsive receptor is considered by some to be the main neurotransmitter receptor for L-glutamic acid in the CNS. The pharmacology of glutamatergic systems in arthropods is also complicated and there are differences between species (Usherwood, 1978; Nistri & Constanti, 1979; Piek, 1985).
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Sansom, M.S.P., Usherwood, P.N.R. (1986). L-Glutamic Acid Receptors on Locust Muscle: Pharmacological Properties and Single Receptor Channel Studies. In: Roberts, P.J., Storm-Mathisen, J., Bradford, H.F. (eds) Excitatory Amino Acids. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-08479-1_17
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DOI: https://doi.org/10.1007/978-1-349-08479-1_17
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