The Use of Quantitative Immunocyto-Chemistry to Study the Regulation of Tyrosine Hydroxylase in Noradrenergic and Dopaminergic Neural Systems

  • R. H. Benno
  • L. W. Tucker
  • T. H. Joh
  • D. J. Reis
Chapter
Part of the Wenner-Gren Center International Symposium Series book series (WGS)

Abstract

Immunocytochemistry has now established itself as one of the most powerful techniques available for understanding the neurobiology of neuron- specific macromolecules in the brain. Using antibodies directed either against neurotransmitters, (Choy and Watkins, 1977; Steinbusch et al. 1978; Sternberger, 1979), the enzymes required for their biosynthesis (Pickel et al. 1975a, b; Sternberger, 1979), or even receptor associated molecules, (Strader, et. al. 1983) the distribution and biochemical anatomy of specific transmitter classes and their relationship to identifiable neuronal populations has been established.

Keywords

Tyrosine Hydroxylase Enzyme Protein Average Optical Density Noradrenergic Neuron Locus Ceruleus 
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Copyright information

© The Wenner-Gren Centre 1985

Authors and Affiliations

  • R. H. Benno
    • 1
  • L. W. Tucker
    • 1
  • T. H. Joh
    • 1
  • D. J. Reis
    • 1
  1. 1.Laboratory of NeurobiologyCornell University Medical CollegeNew YorkUSA

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