Effects of D-1 and D-2 Receptor Stimulation on Single Unit Activity in the Substantia Nigra and Globus Pallidus

  • J. R. Walters
  • D. A. Bergstrom
  • J. H. Carlson
Chapter
Part of the Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology book series (SSNIC)

Abstract

Since the distinction between D-1 and D-2 dopamine receptor subtypes was first made (Kebabian and Calne, 1979), there has been considerable speculation about the relative roles of these two receptors in mediating the effects of dopamine in the CNS. Several techniques have been utilized to probe this question. These include biochemical investigations of the effects of relatively selective dopamine agonists and antagonists on dopamine synthesis and release, and on factors reflecting the activity of acetylcholine neurons in the striatum (Setler et al., 1978; Euvrard et al., 1979; Jenner and Marsden, 1981; Scatton, 1982; Stoof et al., 1982; Langer et al., 1983; Mereu et al., 1983; Wong et al., 1983). These determinations provide, respectively, an index of dopamine cell activity, an index of presynaptic dopamine receptor function and an index of postsynaptic dopamine receptor function. In addition to these phenomena, reflecting the more immediate aspects of D-1 and D-2 receptor stimulation, other studies have explored the behavioral consequences of stimulating D-1 and D-2 receptors (Setler et al., 1978; Gower and Marriott, 1982; Gershanik et al., 1983; Protais et al., 1983; Rosengarten et al., 1983; Molloy and Waddington, 1984).

Keywords

Firing Rate Substantia Nigra Dopamine Receptor Dopamine Agonist Globus Pallidus 
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Copyright information

© The Contributors 1986

Authors and Affiliations

  • J. R. Walters
  • D. A. Bergstrom
  • J. H. Carlson

There are no affiliations available

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