Midbrain Dopamine Neurons: Electrophysiological Studies on the Acute Effects of Estrogen

  • L. A. Chiodo
  • W. M. Glazer
  • B. S. Bunney
Chapter
Part of the Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology book series (SSNIC)

Abstract

Over the past few years, it has become increasingly evident that the endocrine state, particularly with respect to circulating levels of estrogen, can significantly effect the behavioral response of both humans (Bedard et al. 1979; Nausieda et al. 1979a; Villeneuve et al. 1980) and animals (Bedard et al. 1978; Chiodo et al. 1979, 1981; Gordon et al. 1980; Hruska and Silbergeld 1980; Koller et al. 1980; Niak et al. 1978; Nausieda et al. 1979b; Gordon, 1980) to dopamine (DA)-related drugs. For example, estrogen has been reported to reduce dyskinesias associated with chronic neuroleptic therapy or with L-Dopa administration in humans (Villeneuve et al. 1980; Glazer et al. 1983, 1984), disorders which are thought to be related to a hyperf unctioning of extrapyramidal DA systems.

Keywords

Substantia Nigra Tardive Dyskinesia Estrogen Treatment Estrogen Administration Catechol Estrogen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© The Contributors 1986

Authors and Affiliations

  • L. A. Chiodo
  • W. M. Glazer
  • B. S. Bunney

There are no affiliations available

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