Clinical Pharmacology in Psychiatry pp 111-121 | Cite as
Preliminary assessment of a calf caudate radioreceptor assay for the estimation of neuroleptic drugs in plasma: comparison with other techniques
Abstract
The measurement of neuroleptic activity in the plasma of patients by radioreceptor assay (RRA) was introduced by Creese and Snyder in 1977. It is based on an action common to these compounds, their ability to bind to dopamine (DA) receptors in the brain. The relative potency of neuroleptics in producing this effect has been shown to correlate significantly with their pharmacological potency as gauged by behavioral experiments in animals and their effective clinical doses in man (Creese et al. 1976; Seeman et al. 1976). A considerable practical advantage is that any drug having this action and its active metabolites can be measured by a single technique.
Keywords
Plasma Drug Level Radioreceptor Assay Fluphenazine Decanoate Haloperidol Concentration Pharmacological PotencyPreview
Unable to display preview. Download preview PDF.
References
- Creese, I. and Snyder, S. H. (1977). A simple and sensitive radioreceptor assay for antischizophrenic drugs in blood. Nature, Lond., 270, 180–2CrossRefGoogle Scholar
- Creese, I., Burt, D. R. and Snyder, S. H. (1976). Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science, N Y., 192, 481–3CrossRefGoogle Scholar
- Curry, S. H., Whelpton, R., De Schepper, P. J., Vranckx, S. and Schiff, A. A. (1979). Kinetics of fluphenazine after fluphenazine dihydrochloride, enanthate and decanoate administration to man. Br. J. clin. Pharmac., 7, 325–31CrossRefGoogle Scholar
- Dencker, S. J., Johansson, R., Lundin, L. and Malm, U. (1978). High doses of fluphenazine enanthate in schizophrenia. A controlled study. Acta psychiat. scand., 57, 405–14PubMedCrossRefGoogle Scholar
- Forsman, A. and Ohman, R. (1974). A gas chromatographic method for determining haloperidol. Naunyn-Schmiedeberg’s Arch. Pharmac., 286, 113–24CrossRefGoogle Scholar
- Franklin, M. (1980). Gas chromatographic measurement of haloperidol in plasma. Clin. Chem., in pressGoogle Scholar
- Lader, S. R. (1980). A radioreceptor assay for neuroleptic drugs in plasma. J. Immunoassay, 1, 57–75PubMedCrossRefGoogle Scholar
- McNeilly, A. S. and Hagen, C. (1974). Prolactin, TSH, LH and FSH responses to a combined LHRH/TRH test at different stages of the menstrual cycle. Clin. Endocr., 3, 427–35PubMedCrossRefGoogle Scholar
- Michiels, M., Hendriks, R. and Heykants, J. (1976). In Haloperidol Radioimmunoassay Kit. Instructions for Use, IRE, Fleurus, BelgiumGoogle Scholar
- Seeman, P., Lee, T., Chau-Wong, M. and Wong, K. (1976). Antipsychotic drug doses and neuroleptic/dopamine receptors. Nature, Lond., 261, 717–9CrossRefGoogle Scholar
- Tune, L. E., Creese, I., Coyle, J. T., Pearson, G. and Snyder, S. H. (1980). Low neuroleptic serum levels in patients receiving fluphenazine decanoate. Am. J. Psychiat., 137, 80–2PubMedCrossRefGoogle Scholar
- Van Den Eeckhout, E., Belpaire, F. M., Bogaert, M. G. and De Moerloose, P. Radioimmunoassay of bromperidol and haloperidol in human and canine plasma. Janssen Pharmaceutica, Information ServiceGoogle Scholar
- Wiles, D. H. and Franklin, M. (1978). Radioimmunoassay for fluphenazine in human plasma. Br. J. clin. Pharmac., 5, 265–8CrossRefGoogle Scholar
- Wiles, D. H. and Gelder, M. G. (1979). Plasma fluphenazine levels by radioimmunoassay in schizophrenic patients treated with depot injections of fluphenazine decanoate. Br. J. clin. Pharmac., 8, 565–70CrossRefGoogle Scholar