CNS Complications of Malignant Disease pp 306-323 | Cite as
Chemical Markers in Spinal Fluid for Tumours of the Central Nervous System (CNS)
Chapter
Abstract
Until recently the accurate diagnosis and assessment of malignant disease in the central nervous system (CNS) has been costly and time-consuming. The advent of computerised axial tomography (CT scanning) has resulted in a major change in policy in many neurological units, but the technique is not yet generally available. Moreover, and in common with most other methods of diagnosis, CT scanning is limited by its inability to reflect the degree of viability of the solid or fluid lesions which are visualised.
Keywords
Brain Metastasis Pituitary Tumour Primary Brain Tumour Cerebral Metastasis Triose Phosphate Isomerase
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Preview
Unable to display preview. Download preview PDF.
References
- Abelev, G. (1971). Alpha feto-protein in ontogenesis and its association with malignant tumours. Adv. Cancer Res., 14, 295.PubMedCrossRefGoogle Scholar
- Allen, J. P., Kendall, J. W., McGilvra, R. and’Vancura, C. (1974). Immunoreactive ACTH in cerebrospinal fluid. J. clin. Endocr. Metab., 38, 586.PubMedCrossRefGoogle Scholar
- Allen, N. and Reagan, E. (1964). Beta-glucuronidase activities in cerebrospinal fluid. Archs Neurol., 11, 144.CrossRefGoogle Scholar
- Bagshawe, K. D. and Harland, S. (1976). Immunodiagnosis and monitoring of gonadotrophin-producing metastases in the central nervous system. Cancer, 38, 112.PubMedCrossRefGoogle Scholar
- Bagshawe, K. D. (1976). Risk and prognostic factors in trophoblastic neoplasia. Cancer, 38, 1373.PubMedCrossRefGoogle Scholar
- Bagshawe, K. D. (1977). In G. Mathe (ed), Treatment of trophoblastic tumours. Recent Results in Cancer Research p. 192. Springer-Verlag.Google Scholar
- Barone, A. (1948). L’attivita lisozimica attuale del liquor nelle malatti nervose. Acta Neurol. Italia, 3, 434.Google Scholar
- Braunstein, G. D., McIntire, K. R. and Waldmann, T. A. (1973). Discordance of human chorionic gonadotropin and alpha-fetoprotein in testicular teratocarcinomas. Cancer, 31, 1065.PubMedCrossRefGoogle Scholar
- Brightman, M. W., Klatzo, I., Olsson, Y. and Reese, T. S. (1970). The blood-brain barrier to proteins under normal and pathological conditions. J. nurol. Sei., 10, 215.CrossRefGoogle Scholar
- Clausen, J. (1961). Proteins in normal cerebrospinal fluid not found in serum. Proc. Soc. exp. Biol. Med., 107, 170.PubMedCrossRefGoogle Scholar
- Dude, B. G. M., Salmon, S. E. and Russell, D. H. (1977). Polyamines as markers of response and disease activity in cancer chemotherapy. Cancer Res., 37, 214.Google Scholar
- Fleisher, J. H., Marton, L. J., Bachur, N. R. and Mann-Kaplan, R. S. (1973). Cholesterol in cerebrospinal fluid of brain tumour patients. Life Sci., 13, 1517.PubMedCrossRefGoogle Scholar
- Frithz, G., Ericsson, P. and Ronquist, G. (1977). Adenylate kinase activity in cerebrospinal fluid in connection with transitory ischaemic attacks. Uppsala J. Med., 82, 11.CrossRefGoogle Scholar
- Fumagalli, M. D. and Paoletti, P. (1971). Sterol test for human brain tumours: relationship with different oncotypes. Neurology, 21, 1149.PubMedCrossRefGoogle Scholar
- Haghbin, M., Tan, C. T. C., Clarkson, B. D., Mike, V. and Burchenal, J. H. (1975). Treatment of acute lymphoblastic leukaemia in children with ‘prophylactic’ intrathecal methotrexate and intensive chemotherapy. Cancer Res., 35, 807.PubMedGoogle Scholar
- Hildebrand, J. (1973). Early diagnosis of brain metastases in an unselected population of cancerous patients. Eur. J. Cancer, 9, 621.PubMedCrossRefGoogle Scholar
- Hildebrand, J. and Levin, S. (1973). Enzymatic activities in cerebrospinal fluid in patients with neurological diseases. Acta Neurol. Belg., 73, 229.PubMedGoogle Scholar
- Houck, J. C., McBride, H. J. and O’Doherty, D. S. (1968). The value of cerebrospinal fluid glycoprotein levels in the diagnosis of primary brain tumour. Neurology, 18, 397.PubMedCrossRefGoogle Scholar
- Jordan, R. M., Kendall, J. W., Senich, J. L., Allen, J. P., Paulsen, C. A., Kerber, C. W. and Vanderlaan, W. P. (1976). Cerebrospinal fluid hormone concentra-tions in the evaluation of pituitary tumours. Ann. intern. Med., 85, 49.PubMedCrossRefGoogle Scholar
- Kardana, A. and Bagshawe, K. D. (1976). A rapid, sensitive and specific radio-immunoassay for human chorionic gonadotrophin. J. immunol. Meth., 9, 297.CrossRefGoogle Scholar
- Kubinski, H. and Javid, M. (1973). Proteins from human cerebrospinal fluid: binding with nucleic acids. Science, 182, 296.PubMedCrossRefGoogle Scholar
- Laterre, E. C., Heremans, J. F. and Carbonaza, A. (1964). Immunological comparison of some proteins found in cerebrospinal fluid, urine and extracts from brain and kidney. Clin. Chim. Acta, 10, 197.PubMedCrossRefGoogle Scholar
- Linfoot, J. A., Garcia, J. F., Wei, W., Fink, R., Sarin, R., Born, J. L. and Lawrence, J. H. (1970). Human growth hormone levels in cerebrospinal fluid. J. clin. Endocr. Meta and, 31, 230.CrossRefGoogle Scholar
- Long, D. M. (1970). Capillary ultrastructure and the blood-brain barrier in human malignant brain tumour. J. Neurosurg., 32, 127.PubMedCrossRefGoogle Scholar
- Marton, L. J., Hely, O., Levin, V. A., Lubich, W. P., Crafts, D. C. and Wilson, C. B. (1976). The relationship of polyamines in cerebrospinal fluid to the presence of central nervous system tumours. Cancer Res., 36, 973.PubMedGoogle Scholar
- Newlands, E. S., Dent, J., Kardana, A., Searle, F. and Bagshawe, K. D. (1976). Serum alpha-fetoprotein and H. C. G. in patients with testicular tumours. Lancet, ii, 744.Google Scholar
- Paoletti, P., Vandenheuvel, F. A., Fumagalli, R. and Paoletti, R. (1969). The sterol test for the diagnosis of human brain tumours. Neurology, 19, 190.PubMedCrossRefGoogle Scholar
- Reitamo, S. and Klockars, M. (1976). Lysozyme activity in cerebrospinal fluid. Acta Med. Scand., 199, 321.PubMedCrossRefGoogle Scholar
- Rennert, O. M., Lawson, D. L., Shukla, J. B. and Miale, T. D. (1977). Cerebrospinal fluid polyamine monitoring in central nervous system leukaemia. Clin. Chim. Acta, 75, 365.PubMedCrossRefGoogle Scholar
- Ronquist, G., Frithz, G., Ericsson, P. and Hugosson, R. (1977). Malignant brain tumours associated with adenylate kinase in cerebrospinal fluid. Lancet, i, 1284.Google Scholar
- Ruoslahti, E. and Seppala, M. (1972). Alpha-fetoprotein in normal human serum.Nature, 235, 161.Google Scholar
- Schroeder, L. L., Johnson, J. C. and Malarkey, W. B. (1976). Cerebrospinal fluid prolactin: a reflection of abnormal prolactin secretion in patients with pituitary tumours. J. clin. Endocr. Metab., 43, 1255.PubMedCrossRefGoogle Scholar
- Smith, J. A., Francis, T. I., Edington, G. M. and Williams, A. O. (1971). Human alpha fetoprotein in body fluids. Br. J. Cancer, 25, 337.PubMedPubMedCentralCrossRefGoogle Scholar
- Stiffel, M., Dittmann, J., Faulhauer, K. and Loew, F. (1973). Enzymes in cerebrospinal fluid in normal samples, samples from patients with brain tumours, and other neurological diseases. Wien Z. Nervenheilkd., 31, 325.Google Scholar
- Weber, E. L. (1972). Electrophoretic analysis of cerebrospinal fluid proteins in patients with central nervous system mass lesions. J. Neurosurg., 36, 679.PubMedCrossRefGoogle Scholar
- Weiss, J. F., Ransohoff, J. and Kayden, H. J. (1972). Cerebrospinal fluid sterols in patients undergoing treatment for gliomas. Neurology, 22, 187.PubMedCrossRefGoogle Scholar
- Weiss, R. R., Macri, J. M. and Elligers, K.W. (1976). Origin of amniotic fluid alpha-fetoprotein in normal and defective pregnancies. Obst. Gynec., 47, 697.Google Scholar
Copyright information
© S. B. Kaye and K. D. Bagshawe 1979