Nomograms and the Elderly: Applications in Genitourinary Oncology
Abstract
Of all available clinical prediction tools, nomograms have been shown to provide the most accurate and practical individualized risk estimations, and for this reason, they have greatly grown in popularity in the modern era of medicine. These models function to replicate the clinical predictions of physicians in a reliable, unbiased, and evidence-based format that can provide patients with the necessary information to make a fully informed decision regarding treatment. The relevant clinical considerations – and, thus, the corresponding outcome predictions – may differ between populations of varying age, and nomograms predicting disease risk, quality of life, and mortality will likely be most relevant to an elderly population. The future of outcomes research should focus on the combination of multiple prediction models into comparative effectiveness tables which will serve as high-quality informed consent for the older patient contemplating therapy. While nomograms can help us to move beyond an era of age cutoff points, these and other prediction models will never be able to substitute for the clinical acumen and watchful eye of a thoughtful physician.
Keywords
Elderly Comparative effectiveness Nomograms Prediction toolsReferences
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