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Selective Regulation of Protein Activity by Complex Ca2+ Oscillations: A Theoretical Study

  • Beate Knoke
  • Marko Marhl
  • Stefan Schuster
Part of the Modeling and Simulation in Science, Engineering and Technology book series (MSSET)

Summary

Calcium oscillations play an important role in intracellular signal transduction. As a second messenger, Ca2+ represents a link between several input signals and several target processes in the cell. Whereas the frequency of simple Ca2+ oscillations enables a selective activation of a specific protein and herewith a particular process, the question arises of how at the same time two or more classes of proteins can be specifically regulated. The question is general and concerns the problem of how one second messenger can transmit more than one signal simultaneously (bow-tie structure of signalling). To investigate whether a complex Ca2+ signal like bursting, a succession of low-peak and high-peak oscillatory phases, could selectively activate different proteins, several bursting patterns with simplified square pulses were applied in a theoretical model. The results indicate that bursting Ca2+ oscillations allow a differential regulation of two different calcium-binding proteins, and hence, perform the desired function.

Keywords

Bow-tie structure of signalling calcium oscillations bursting decoding 

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Copyright information

© springer 2007

Authors and Affiliations

  • Beate Knoke
    • 2
  • Marko Marhl
    • 1
  • Stefan Schuster
    • 2
  1. 1.Dept. of Bioinformatics, Faculty of Biology and PharmaceuticsFriedrich-Schiller University of JenaErnst-Abbe-Platz 2Germany
  2. 2.Dept. of Physics, Faculty of Education, University of Maribor, MariborUniversity of Maribor2000 MariborSlovenia

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