Transplantation of the Heart and Both Lungs- Experimental Background and Early Clinical Experience

  • E. Becerra
  • J. Kaplan
  • D. K. C. Cooper
Chapter

Abstract

Transplantation of the heart and both lungs only became a clinical reality in the 1980s, largely due to the introduction of cyclosporin, which enabled the patient to be immunosuppressed adequately during the first 2–3 weeks without the need for a corticosteroid. The ability to immunosuppress the patient sufficiently without a corticosteroid allowed time for healing of the tracheal suture line, which previously was a major source of early complication following this operation.

Keywords

Lung Transplantation Early Clinical Experience Bilareral Lung Transplantation Respiratory Paralysis Atrioventricular Canal Defect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. 1.
    Cooper DKC. Transplantation of the heart and both lungs. I. Historical review. Thorax. 1969;24:383.Google Scholar
  2. 2.
    Carrel A. The surgery of the blood vessels. Johns Hopkins Hosp Bull. 1907; 18:18.Google Scholar
  3. 3.
    Demikhov VP. Experimental transplantation of vital organs. Authorized translation from Russian by Haigh B. New York: Consultants Bureau; 1962.Google Scholar
  4. 4.
    Robicsek F, Pruitt JR, Sanger PW, Daugherty HK, Moore M, Bagby E. The maintenance of function of the donor heart in the extracorporeal stage and during transplantation. Ann Thor Surg. 1968;6:330.CrossRefGoogle Scholar
  5. 5.
    Robicsek F, Tarn W, Daugherty HK, Robicsek LV. The stabilized autoperfusing heart-lung preparation as a vehicle for extracorporeal preservation. Transplant Proc. 1969;1:834.PubMedGoogle Scholar
  6. 6.
    Longmore DB, Cooper DKC, Hall RW, Sekabunga J, Welch W. Transplantation of the heart and both lungs. II. Experimental cardiopulmonary transplantation. Thorax. 1969;24:391.PubMedCrossRefGoogle Scholar
  7. 7.
    Cooper DKC. A simple method of resuscitation and short-term preservation of the canine cadaver heart. J Thorac Cardiovasc Surg. 1975;70:896.PubMedGoogle Scholar
  8. 8.
    Hardesty RL, Griffith BP. Autoperfusion of the heart and lungs for preservation during distant procurement. J Thorac Cardiovasc Surg. 1987;93:11.PubMedGoogle Scholar
  9. 9.
    Marcus E, Wong SNT, Luisada AA. Homologous heart grafts: transplantation of the heart in dogs. Surg Forum. 1951;2:212.Google Scholar
  10. 10.
    Marcus E, Wong SNT, Luisada AA. Homologous heart grafts. I. Technique of interim parabiotic perfusion. II. Transplantation of the heart in dogs. Arch Surg. 1953;66:179.Google Scholar
  11. 11.
    Matejicek E. Transplantation of organs. Transplant Bull. 1956,3:167.Google Scholar
  12. 12.
    Neptune WB, Cookson BA, Bailey C, Appier R, Rajkowski F. Complete homologous heart transplantation. Arch Surg. 1953;66:174.Google Scholar
  13. 13.
    Webb WR, Howard HS. Cardiopulmonary transplantation. Surg Forum. 1957;8:313.PubMedGoogle Scholar
  14. 14.
    Webb WR, Howard HS, Neely WN. Practical methods of homologous cardiac transplantation. J Thorac Surg. 1959;37:361.PubMedGoogle Scholar
  15. 15.
    Webb WR, Guzman V, Hoopes JE. Cardiopulmonary transplantation: experimental study of current problems. Am Surg. 1961;27:236.PubMedGoogle Scholar
  16. 16.
    Blanco G, Adam A, Rodriguez-Perez D, Fernandez A. Complete homotransplantation of the canine heart and lungs. Arch Surg. 1958;76:20.Google Scholar
  17. 17.
    Lower RR, Stofer RC, Hurley EJ, Shumway NE. Complete homograft replacement of the heart and both lungs. Surgery. 1961;50:842.PubMedGoogle Scholar
  18. 18.
    Sen PK, Parulkar GB, Kinare S. Homologous canine heart transplantation: a preliminary report of 100 experiments. Indian J Med Res. 1965;53:674.PubMedGoogle Scholar
  19. 19.
    DeBono AH. La transplantation cardiopulmonaire totale. Ann Chir Thorac Cardiovasc. 1966;5:243.PubMedGoogle Scholar
  20. 20.
    Prop J, Kuijpers K, Petersen AH, Bartels HL, Nieuwenhuis P, Wildevuur CH. Why are lung allografts more vigorously rejected than hearts? J Heart Transplant. 1985;4:433.PubMedGoogle Scholar
  21. 21.
    Novitzky D, Cooper DKC, Wicomb WN, Rose AG, Reichart B. Transplantation of the heart and both lungs: experimental and clinical experience and review of the literature. S Afr Med J. 1985;67:575.PubMedGoogle Scholar
  22. 22.
    McGregor CGA, Baldwin JC, Jamieson SW et al. Isolated pulmonary rejection after combined heart-lung transplantation. J Thorac Cardiovasc Surg., 1985;90:623.PubMedGoogle Scholar
  23. 23.
    Grinnan GLB, Graham WH, Childs JW, Lower RR. Cardiopulmonary homotransplantation. J Thorac Cardiovasc Surg. 1970;60:609.PubMedGoogle Scholar
  24. 24.
    Nakae S, Webb WR, Theodorides T, Sugg WL. Respiratory function following cardiopulmonary denervation in dog, cat, and monkey. Surg Gynecol Obstet. 1967;125:1285.PubMedGoogle Scholar
  25. 25.
    Castaneda AR, Zamora R, Schmidt-Habelmann P et al. Cardiopulmonary autotransplantation in primates (baboons). Late functional results. Surgery. 1972;72:1064.PubMedGoogle Scholar
  26. 26.
    Haglin J, Telander RL, Muzzall RE, Kiser JC, Strobel CJ. Comparison of lung autotransplantation in the primate and dog. Surg Forum. 1963;14:196.PubMedGoogle Scholar
  27. 27.
    Reitz B, Burton NA, Jamieson S et al. J Thorac Cardiovasc Surg. 1980;80:360.PubMedGoogle Scholar
  28. 28.
    Reitz BA. Heart and lung transplantation. J Heart Transplant. 1981;1:80.Google Scholar
  29. 29.
    Cooper DKC, Novitzky D, Rose AG, Reichart BA. Acute pulmonary rejection precedes cardiac rejection following heart-lung transplantation in a primate model. J Heart Transplant. 1986;5:29.PubMedGoogle Scholar
  30. 30.
    Cooley DA, Bloodwell RD, Hallman GL, Nora JJ, Harrison JM, Leachman RD. Organ transplantation for advanced cardiopulmonary disease. Ann Thorac Surg. 1969;8:30.PubMedCrossRefGoogle Scholar
  31. 31.
    Ullehei CW. Discussion of Wildevuur, C.R.H. and Benfield, J.R. A review of 23 human lung transplantations by 20 surgeons. Ann Thorac Surg. 1970;9:515.Google Scholar
  32. 32.
    Barnard CN, Cooper DKC. Clinical transplantation of the heart: a review of 13 years personal experience. J Roy Soc Med. 1981;74:670.PubMedGoogle Scholar
  33. 33.
    Losman JG, Campbell CD, Replogle RL, Barnard CN. Joint transplantation of the heart and lungs. Past experience and present potentials. J Cardiovasc Surg. 1982:23:440.Google Scholar
  34. 34.
    Reitz BA, Pennock JL, Shumway NE. Simplified operative method for heart and lung transplantation. J Surg Res. 1981;31:1.PubMedCrossRefGoogle Scholar
  35. 35.
    Reitz BA. Heart-lung transplantation: a review. Heart Transplant. 1982;1:292.Google Scholar
  36. 36.
    Reitz BA, Wallwork J, Hunt SA et al. Heart and lung transplantation: successful therapy for patients with pulmonary vascular disease. N Engl J Med. 1982;306:557.PubMedCrossRefGoogle Scholar
  37. 37.
    Jamieson SW, Ogunnaike HO. Cardiopulmonary transplantation. Surg Clin N Am. 1986;66:491.PubMedGoogle Scholar
  38. 38.
    Jamieson SW, Reitz BA, Oyer PE et al. Combined heart and lung transplantation. Lancet. 1983:1:1130.PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • E. Becerra
  • J. Kaplan
  • D. K. C. Cooper

There are no affiliations available

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